Mitochondrial DAMPs Are Released During Cardiopulmonary Bypass Surgery and Are Associated With Postoperative Atrial Fibrillation

Sandler, Nicola; Kaczmarek, Elżbieta; Itagaki, Kiyoshi; Zheng, Yi; Otterbein, Leo E.; Khabbaz, Kamal R.; Liu, David Ruchien; Senthilnathan, Venkatachalam; Gruen, Russell L.; Hauser, Carl J.

doi:10.1016/j.hlc.2017.02.014

Cited by 75 publications

(66 citation statements)

References 30 publications

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“…In addition, tissue injury releases mitochondrial damage–associated molecular patterns including mitochondrial DNA, which can act as a direct activator of neutrophils, which in turn elicit a systemic inflammatory response syndrome while suppressing polymorphonuclear function. Such molecular patterns have also been seen during CPB and, as such, may participate in the pathogenesis of CVS‐AKI …”

Section: Resultsmentioning

confidence: 83%

See 1 more Smart Citation

Cardiac and Vascular Surgery–Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group

Nadim

Forni

Bïhorac

et al. 2018

JAHA

231

191

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Section: Resultsmentioning

confidence: 83%

“…Such molecular patterns have also been seen during CPB and, as such, may participate in the pathogenesis of CVS-AKI. 54…”

Section: Other Mechanismsmentioning

confidence: 99%

Cardiac and Vascular Surgery–Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group

Nadim

Forni

Bïhorac

et al. 2018

JAHA

231

191

View full text Add to dashboard Cite

“…Also upon femoral reaming or cardiopulmonary bypass surgery, high quantities of mtDAMPs were identified [285]. Even more, the higher concentrations of mtDNA correlated with postoperative complications [273]. Interestingly, endotracheal tube placement in surgery has been associated with higher concentrations of mtDNA in throat lavage fluid, and a correlation between non-infected sore throat post-intubation and elevated throat lavage mtDNA concentration was found [286].…”

Section: Nucleic Acidsmentioning

confidence: 99%

“…Thus, cfDNA acts as potent immunothrombotic agents [265]. Increased levels of cfDNA in the form of nuclear DNA (nDNA), mtDNA, or NETs were found and correlated with detrimental outcomes in patients with sepsis [269,270], cancer [271], autoimmune disease [272], cardiopulmonary bypass surgery [273], and solid organ transplantation [274].…”

Section: Nucleic Acidsmentioning

confidence: 99%

Damage-associated molecular patterns in trauma

Relja

Land

2019

Eur J Trauma Emerg Surg

139

131

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In 1994, the "danger model" argued that adaptive immune responses are driven rather by molecules released upon tissue damage than by the recognition of "strange" molecules. Thus, an alternative to the "self versus non-self recognition model" has been provided. The model, which suggests that the immune system discriminates dangerous from safe molecules, has established the basis for the future designation of damage-associated molecular patterns (DAMPs), a term that was coined by Walter G. Land, Seong, and Matzinger. The pathological importance of DAMPs is barely somewhere else evident as in the posttraumatic or post-surgical inflammation and regeneration. Since DAMPs have been identified to trigger specific immune responses and inflammation, which is not necessarily detrimental but also regenerative, it still remains difficult to describe their "friend or foe" role in the posttraumatic immunogenicity and healing process. DAMPs can be used as biomarkers to indicate and/or to monitor a disease or injury severity, but they also may serve as clinically applicable parameters for optimized indication of the timing for, i.e., secondary surgeries. While experimental studies allow the detection of these biomarkers on different levels including cellular, tissue, and circulatory milieu, this is not always easily transferable to the human situation. Thus, in this review, we focus on the recent literature dealing with the pathophysiological importance of DAMPs after traumatic injury. Since dysregulated inflammation in traumatized patients always implies disturbed resolution of inflammation, so-called model of suppressing/inhibiting inducible DAMPs (SAMPs) will be very briefly introduced. Thus, an update on this topic in the field of trauma will be provided.

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“…Likewise, Sandler et al found elevated concentrations of mtDNA in patients following cardiopulmonary bypass surgery. Interestingly, the higher concentrations of mtDNA correlated with post-operative complications [35]. …”

Section: Release Of Cf-mtdna Via Cell Necrosis In Trauma and Surgerymentioning

confidence: 99%

The source of cell-free mitochondrial DNA in trauma and potential therapeutic strategies

Thurairajah

Briggs

Balogh

2018

Eur J Trauma Emerg Surg

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Mitochondria play a key role in the pathophysiology of post-injury inflammation. Cell-free mitochondrial DNA (cf-mtDNA) is now understood to catalyse sterile inflammation after trauma. Observations in trauma cohorts have identified high cf-mtDNA in patients with systemic inflammatory response syndrome and multiple organ failure as well as following major surgery. The source of cf-mtDNA can be various cells affected by mechanical and hypoxic injury (passive mechanism) or induced by inflammatory mechanisms (active mechanism). Multiple forms of cf-mtDNA exist; mtDNA fragments, mtDNA in microparticles/vesicles and cell-free mitochondria. Trauma to cells that are rich in mitochondria are believed to release more cf-mtDNA. This review describes the current understanding of the mechanisms of cf-mtDNA release, its systemic effects and the potential therapeutic implications related to its modification. Although current understanding is insufficient to change trauma management, focussed research goals have been identified to pave the way for monitoring and manipulation of cf-mtDNA release and effects in trauma.

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Mitochondrial DAMPs Are Released During Cardiopulmonary Bypass Surgery and Are Associated With Postoperative Atrial Fibrillation

Cited by 75 publications

References 30 publications

Cardiac and Vascular Surgery–Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group

Cardiac and Vascular Surgery–Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group

Damage-associated molecular patterns in trauma

The source of cell-free mitochondrial DNA in trauma and potential therapeutic strategies

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