Mitochondrial DNA Alterations and Oxidative Stress in Acute Leukemia

Saadaoui, Mouna; Aissaouï, Lamia; Salaün, Véronique; Manaï, Mohamed; Allouche, Stéphane

doi:10.2174/1876816420130418001

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…Reactive oxygen species (ROS) has long been known to be involved in the pathophysiology of cancer (Valko et al, 2006). The most common cancers in children are leukemia and the oxidative stress is a crucial feature of ALL (Battisti et al, 2008;Mazor et al, 2008;Saadaoui et al, 2013). Meanwhile recent advances in the field of reproductive medicine have focused the attention of many researchers to consider ROS as one of the mediators of infertility causing sperm dysfunction (Agarwal and Prabakaran, 2005;Singh, 2012).…”

Section: Discussionmentioning

confidence: 99%

Correlation of Inhibin and Several Antioxidants in Children with Acute Lymphoblastic Leukemia

Mehde¹,

Mehdi²,

Zainulabdeen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Acute lymphoblastic leukemia (ALL) is most common in childhood. Inhibin (a non-steroidal glycoprotein hormone of gonadal origin) can be used as marker of fertility. The current study was conducted to evaluate inhibin levels in ALL patients and to estimate its correlation with some antioxidants in these in comparison with control subjects. Materials and Methods: This study was conducted on sixty patients with ALL and thirty children as controls. Fasting blood samples were taken from each subject and analyzed for haemoglobin, serum protein, vitamin E and C, in addition to glutathione and inhibin. Results: The results of the study showed highly significant decreases (p<0.001) in haemoglobin, glutathione and inhibin levels with significant decreases (p<0.05) in serum protein and vitamin E levels for patients group in comparison with controls while there was no significant differences in vitamin C. Moreover, there were significant correlations between inhibin levels and serum protein, glutathione and both vitamins (E and C) in the ALL patient group (r= 0.81, 0.80, 0.77 and 0.69, respectively). Conclusions: The present results indicated infertility in patients with ALL demonstrated by low inhibin level as a consequence of abnormality in anti-oxidative metabolism due to the cancer process. So, it can be suggested the need for routine measurement of inhibin for leukemic patients to estimate the action of hormones of gonadal origin.

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Section: Discussionmentioning

confidence: 99%

Correlation of Inhibin and Several Antioxidants in Children with Acute Lymphoblastic Leukemia

Mehde¹,

Mehdi²,

Zainulabdeen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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show abstract

“…The increase in mitochondrial mass and MtDNA content may be an early molecular event of human cells in response to endogenous or exogenous oxidative stress. Exposure to benzene increases the generation of ROS in the mitochondria and increases the risk of leukemia and other benzene related‐malignancies (Shen et al ., 2008; Saadaoui et al ., 2013). The monitored level of PM10 in the present study exceeds the permissible limit of CPCB, India as well study showed significant elevated urinary benzene metabolite (phenol), oxidative stress and increased level of MtDNAcn among fuel filling attendants.…”

Section: Discussionmentioning

confidence: 99%