Mitochondrial DNA control region data reveal high prevalence of Native American lineages in Jujuy province, NW Argentina

Cardoso, Sergio; Palencia-Madrid, Leire; Valverde, Laura; Alfonso‐Sánchez, Miguel Á.; Gómez-Pérez, Luis; Alfaro, Emma; Bravi, Cláudio M.; Dipierri, José Edgardo; Peña, José A.; Pancorbo, Marian M. de

doi:10.1016/j.fsigen.2013.01.007

Cited by 27 publications

(27 citation statements)

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“…DC3 tiene la mutación 16234G descripta en muestras modernas del NOA pero en las cuales está acompañada de otras mutaciones extras a la nodal, como es el caso del DC9 que además posee la 16256T y la 16192T (Tabla 3). El patrón 16234G+16256T está presente en muestras actuales de La Quiaca, una de Tapacari (Taboada-Echalar et al, 2013) y en una muestra de Jujuy (Cardoso et al, 2013). Por su parte el DC7 presentó un haplotipo similar al de individuos guaraníes (Marrero et al, 2007) pero con la mutación extra 16162G.…”

Section: Resultsunclassified

“…Otro ejemplo es el haplotipo del individuo DC7 el cual está presente en guaraníes actuales del NEA pero sin la mutación 16162G. Sólo uno de los individuos, DC14, presentó un linaje que ha sido hallado en un individuo precolombino de la Quebrada de Humahuaca , en muestras actuales de la Puna (Álvarez-Iglesias et al, 2007;Cardoso et al, 2013), en Wichis y Qom de la provincia de Formosa (Cabana et al, 2006), en individuos de la cuenca del lago Titicaca en Bolivia (Barbieri et al, 2011) Por otra parte, la posible incidencia de procesos demográficos como la contracción o reemplazo poblacional podría explicar la ausencia de muchos linajes antiguos en la actualidad. Si estimamos en 25 a 30 años el intervalo generacional tendríamos más de veinte generaciones de horizonte temporal para la potencial acción de estos procesos sobre las muestras actuales de la zona.…”

Section: Discussionunclassified

“…Se utilizaron fuentes bibliográficas de poblaciones actuales del NOA (Cabana et al, 2006;Álvarez-Iglesias et al, 2007;Marrero et al, 2007;Tamm et al, 2007;Sala et al, 2010;Barbieri et al, 2011;de Saint Pierre et al, 2012;Cardoso et al, 2013;Taboada-Echalar et al, 2013;Sala y Corach, 2014) para cotejar si los haplotipos encontrados en la muestra antigua de Puna jujeña presentan continuidad en la región.…”

Section: Análisis De Las Secuenciasunclassified

“…Otro estudio en muestras poblacionales contemporáneas de diferentes regiones de Jujuy, ha demostrado también la presencia de los linajes A2 (13.9%), B4b (56.7%), C1 (17.8%), D1 (8.9%) y D4h3a (1.1%) (Cardoso et al, 2013). La presencia de linajes prehispánicos en muestras actuales daría indicios de continuidad biológica.…”

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Linajes Maternos en Muestras Antiguas De La Puna Jujeña. Comparacion Con Estudios De La Region Centro-Sur Andina

Postillone

Fuchs²,

Crespo³

et al. 2016

Rev Arg Antrop Biol

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RESUMEN Las evidencias arqueológicas proporcionan abundantes pruebas de una activa interacción entre las poblaciones de lo que actualmente es el noroeste de Argentina, el sur de Perú, el oeste de Bolivia y el norte de Chile. Los estudios de ADN en individuos prehispánicos, a su vez, proveen información directa sobre la historia biológica y la dinámica de los grupos humanos, y aportan nuevas perspectivas a la comprensión de la dispersión y variabilidad de los amerindios. El objetivo de este trabajo es analizar los linajes maternos presentes en individuos del período tardío de la Puna jujeña (1000-1450 AD) mediante la comparación de su composición genética con las de otros grupos precolombinos de la región centro-sur andina descriptos por otros autores. A partir de las secuencias de HVR I del ADN mitocondrial se determinó PALABRAS CLAVE ADNmt; haplotipos; ADN antiguo; Puna jujeña la variabilidad genética inter e intramuestral, además de la distancia genética entre los diversos grupos utilizados. En las muestras analizadas el linaje más frecuente fue el A2, el cual mostró una gran variabilidad haplotípica. Esto lo diferencia de otros estudios de la región andina en los que se ha descripto el predominio de los linajes B2. A una escala local, las distancias genéticas entre la Puna jujeña y otros grupos poblacionales del actual noroeste argentino no fueron significativas, a excepción de Pampa Grande, de la que se encuentra más alejada geográfica y espacialmente. A nivel regional, las diferencias son significativas con respecto a la mayoría de las muestras antiguas de Perú, aunque no evidencian un patrón espacial o temporal determinado.ABSTRACT Archaeological records provide abundant evidence of an active interaction between the peoples of what are now northwestern Argentina, southern Peru, western Bolivia, and northern Chile. Likewise, DNA studies in prehispanic individuals provide direct information on the biological history and dynamics of human groups, offering new perspectives to the understanding of dispersion and variability of Native Americans. The aim of this paper is to analyze the maternal lineages present in individuals from the late period of the Puna region (1000-1450 AD) by comparing their genetic composition with other pre-Columbian groups from the south-central Andean region, described by other authors. From mtDNA HVR-I sequences, inter-and intra-sample ge-netic variability was determined, as well as the genetic distance between the various groups used. In the samples analyzed, A2 was found to be the most common lineage,, showing high haplotype variability, and contrasting with other studies in the Andean region, which described the prevalence of B2 lineages. At a local level, the genetic distances between the Puna population and other groups from presentday northwestern Argentina were not significant, except for Pampa Grande, which is more geographically and spatially remote. At a regional level, the differences are significant in relation to the majority of Peru ancient samples, but do not show a part...

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Section: Resultsunclassified

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Linajes Maternos en Muestras Antiguas De La Puna Jujeña. Comparacion Con Estudios De La Region Centro-Sur Andina

Postillone

Fuchs²,

Crespo³

et al. 2016

Rev Arg Antrop Biol

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“…The population census of 1778 already registered large differences in the proportions of Amerindians, Africans and Europeans between the different regions of the province (see Dipierri et al, ). At the same time, the steep orography of Jujuy could also have acted as a physical barrier to interregional migration among Jujuy's Native American communities (Cardoso et al, ; Gómez‐Pérez et al, ; Gómez‐Pérez, Alfonso‐Sánchez, Dipierri, & Peña, ).…”

Section: Introductionmentioning

confidence: 99%

Paternal heritage in Jujuy province (Northwest Argentina): Evidence for sex‐biased gene flow and genetic drift effects

Alfonso‐Sánchez

Gómez-Pérez

Dipierri

et al. 2019

American J Hum Biol

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Objectives: This study aimed to explore the diversity of paternal lineages in Jujuy province (Argentina) by analyzing Y chromosome markers. Furthermore, we examined among-population genetic variability based both on paternally (NRY haplotypes) and maternally (mtDNA haplogroups) inherited markers. We sought to evaluate the impact of sex-biased gene flow on genetic background in Jujuy, and contribute data on the microevolutionary forces acting in this zone. Methods: DNA from 149 males from five Jujuy regions were analyzed for 12 nonrecombining Y (NRY) markers. Genetic heterogeneity among Jujuy regions was evaluated through population differentiation tests. To identify potential genetic boundaries in Jujuy, analysis of molecular variance (AMOVA) and the Monmonier's algorithm implemented in the Barrier v2.2 software were employed. Results: A clear divergence between Jujuy highlands and lowlands for NRY haplotypes was found. A marked discrepancy between genetic structuring for paternal lineages and the lack of geographical pattern for mitogenomes was confirmed by all statistical analyses. Conclusions: Genetic structuring of paternal lineages is most likely caused by admixture processes that have occurred since colonial times in the Jujuy lowlands.Immigrants were predominantly male that settled in the lower altitude zones, due to the steep orography of the region. Input of allochthonous male lineages because of gene flow toward the lowlands would have increased diversity of NRY markers, thus compensating for drift effects. Likewise, limited input of allochthonous mitogenomes would have promoted genetic drift, a key factor in the shaping of diversity of maternal lineages across Jujuy subpopulations, irrespective of altitude.

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Proportionality indices, geographic altitude, and gestational age in newborns from Jujuy, Argentina

Martínez

Revollo

Alfaro

et al. 2020

American J Hum Biol

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Background There are several different proportionality indices (PRIs) to evaluate size at birth by gestational age (GA). Yet, the explanatory power of alternative PRIs has not been evaluated in highland (HL) populations. Aim Evaluate the relative utility of three PRIs, weight to length ratio (W/L), body mass index (BMI), and ponderal index (PI), for assessing nutritional status in newborns (NBs) from highland (HL ≥ 2000 m) and lowland (LL < 2000 m) regions of the Jujuy Province of Argentina. Subjects and methods Births were registered by the Ministry of Health (Jujuy, 2009‐2014). Data were grouped according to HL and LL altitude groups based on of maternal residence. The main outcome measures were the PRIs W/L ratio, BMI, and PI. Percentiles were generated by the LMS method and compared with references. ANOVAs and Pearson correlations were used to examine the relationship between outcome measures with weight and length by altitude, sex, and GA. Results In both altitude zones, W/L and BMI increased with GA, while PI stabilized between 37th and 42th weeks. The LL sample had significantly higher values for all the PRIs from the 37th week of GA. In the HL sample, the 50th percentiles for all three PRIs were lower than the reference. Regardless of GA and altitude level, BMI showed the lowest correlation with length and the higher with the weight. Conclusion The HL sample of term NBs had lower values for all PRIs compared to their LL counterparts. In both altitude zones, the BMI is the preferred PRI to evaluate the nutritional status.

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Mitochondrial DNA control region data reveal high prevalence of Native American lineages in Jujuy province, NW Argentina

Cited by 27 publications

References 30 publications

Linajes Maternos en Muestras Antiguas De La Puna Jujeña. Comparacion Con Estudios De La Region Centro-Sur Andina

Linajes Maternos en Muestras Antiguas De La Puna Jujeña. Comparacion Con Estudios De La Region Centro-Sur Andina

Paternal heritage in Jujuy province (Northwest Argentina): Evidence for sex‐biased gene flow and genetic drift effects

Proportionality indices, geographic altitude, and gestational age in newborns from Jujuy, Argentina

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