Mitochondrial DNA control region haplotype and haplogroup diversity in South Eastern Turkey

Serin, Ayşe; Canan, Husniye; Alper, Behnan; Gülmen, Mete Korkut; Zimmermann, Bettina; Parson, Walther

doi:10.1016/j.fsigen.2016.07.011

Cited by 16 publications

(13 citation statements)

References 27 publications

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“…This ancient dataset contained 467 individuals in total, including Çemialo Sırtı individuals ( n = 10–88 individuals per population, median = 24). The modern‐day populations were chosen from west Asia and south Europe (Alkan et al, ; Brisighelli et al, ; Comas, Calafell, Mateu, Perez‐Lezaun, & Bertranpetit, ; Comas et al, ; González et al, ; Irwin et al, ; Nasidze & Stoneking, ; Ottoni et al, ; Roostalu et al, ; Schönberg, Theunert, Li, Stoneking, & Nasidze, ; Serin et al, ; Vernesi et al, ), summing up to a total of 1,483 individuals ( n = 30–286 individuals per population, median = 90).…”

Section: Resultsmentioning

confidence: 99%

Archaeogenetics of Late Iron Age Çemialo Sırtı, Batman: Investigating maternal genetic continuity in north Mesopotamia since the Neolithic

Yaka

Birand

Yılmaz

et al. 2018

American J Phys Anthropol

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Section: Resultsmentioning

confidence: 99%

Archaeogenetics of Late Iron Age Çemialo Sırtı, Batman: Investigating maternal genetic continuity in north Mesopotamia since the Neolithic

Yaka

Birand

Yılmaz

et al. 2018

American J Phys Anthropol

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“…A nucleotide substitution of cytosine (C) to thymine (T) at the 16223 base position has been observed with the frequencies of 20%, 11.7%, and 14.2% in southern, northern, and western Anatolia, respectively (12,17). Moreover, a heteroplasmic transversion position C16176G has been observed in four Southern Eastern Turkish subjects (17). However, they did not detect variations at the nucleotide positions 16173 and 16175.…”

Section: Discussionmentioning

confidence: 89%

“…In the study, 75 unrelated Turkish subjects from all around the Anatolia were examined for allelic sequence polymorphism of the CR of human mtDNA. An expanded study by Serin et al (17) examined the mtDNA CR of 224 subjects from Southeastern Turkey. A nucleotide substitution of cytosine (C) to thymine (T) at the 16223 base position has been observed with the frequencies of 20%, 11.7%, and 14.2% in southern, northern, and western Anatolia, respectively (12,17).…”

Section: Discussionmentioning

confidence: 99%

“…An expanded study by Serin et al (17) examined the mtDNA CR of 224 subjects from Southeastern Turkey. A nucleotide substitution of cytosine (C) to thymine (T) at the 16223 base position has been observed with the frequencies of 20%, 11.7%, and 14.2% in southern, northern, and western Anatolia, respectively (12,17). Moreover, a heteroplasmic transversion position C16176G has been observed in four Southern Eastern Turkish subjects (17).…”

Section: Discussionmentioning

confidence: 99%

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Identification of a novel mitochondrial DNA sequence variation within the human mitochondrial DNA Control Region in a population of Aegean population

Köseler¹

2019

Erciyes Med J

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Objective: Environmental impacts, history as well as established cultural regulations, and many more other factors had shaped broadly diverse structure of human genetic patterns. A control region of human mtDNA has served as a good genetic determination marker in many fields such as evolutionary studies and forensic genetics. The allelic variations of mtDNA have been studied in many populations including Turkish populations. Previous studies in Turkish populations lacked large cohorts. In this study, non-coding hypervariable regions of human mitochondrial DNA with extended population of Turkish individuals from Aegean region have been investigated. Materials and Methods: To detect sequence variants in human mtDNA control region, 100 unrelated Turkish subjects were examined. Results: The outcomes revealed 13 variable sites in hypervariable region I (HVRI) and 20 variable sites in hypervariable region II (HVRII). Polymorphisms within HVRI were detected at the positions of 16173 (C>A) and 16175 (A>G) with the allelic variation frequencies of 53% and 60%, respectively. A novel nucleotide transversion from cytosine to adenine at 16173 position was detected. Only 35% of subjects were aligned with the Cambridge Reference Sequence for the poly-cytosine tract that locates between 303 and 309 nucleotides, whereas 60% of individuals had 8 and 15% of them had 10 cytosine polynucleotides. 263G and 73G polymorphisms were evaluated with higher frequencies for the HVSII region. Conclusion: Overall, results indicate that the determination of genotype distributions and allelic variations frequencies of human mitochondrial genome are significant to characterize admixture populations from different ethnic origins.

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“…There is also 1122 bp control region or non coding region that contains the origin of replication for one mtDNA strands, but does not code for any gene products (Ballantyne, 1997). There are three hypervariable regions in the D loop (HVI, HVII, and HVIII); these are important and analyzed to determine human identification (Fujita, 1995;Lee et al, 1997;Kouvatsi et al, 2001;Allard et al, 2002;Imaizumi et al, 2002;Maruyama et al, 2003;Ricaut et al, 2004;Koyama et al, 2008;Serin et al, 2016).…”

Section: Location and Structure Of Human Mitochondrial Dnamentioning

confidence: 99%

Application control region of human mitochondrial DNA in forensic anthropology

Samehsalari¹,

Reddy²

2018

Int.J.Mod.Anthrop

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Mitochondrial genome has particular features that make it a valuable forensic marker; first of all it is present in each somatic cell in high numbers. Therefore, it is more resistant to degradation and more stable under unfavorable conditions than nuclear DNA (nDNA) in highly damaged, degraded or very small quantity of the samples. Secondly, the high mutation rate, lack of recombination and the maternal mode of inheritance are features which make the mitochondrial DNA (mtDNA) better choice in situations where nDNA cannot be used for the analysis. Thus, forensic Anthropologists can determine how mitochondrial DNA may be best utilized in skeletal remains or hair shafts, which essentially lack nDNA but contain sufficient amounts of mtDNA. The most extensive mtDNA variations between individuals are found within the Control region or hypervariable regions (HVI, HVII, and HVIII) which allowed individuals to be differentiated and it could provide evidence about the identity of crime victims, especially skeletal remains. In this article we review the feature of mtDNA and its role as a reliable tool in Forensic Anthropology.

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Mitochondrial DNA control region haplotype and haplogroup diversity in South Eastern Turkey

Cited by 16 publications

References 27 publications

Archaeogenetics of Late Iron Age Çemialo Sırtı, Batman: Investigating maternal genetic continuity in north Mesopotamia since the Neolithic

Archaeogenetics of Late Iron Age Çemialo Sırtı, Batman: Investigating maternal genetic continuity in north Mesopotamia since the Neolithic

Identification of a novel mitochondrial DNA sequence variation within the human mitochondrial DNA Control Region in a population of Aegean population

Application control region of human mitochondrial DNA in forensic anthropology

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