Mitochondrial DNA Copy Number, a Damage-Associated Molecular Pattern Molecule, Can Predict Pancreatic Necrosis and Is Correlated with the Severity of Acute Pancreatitis

Ezzat, Ghada M.; Nageb, Soha M.; Haredi, Mostafa Abd-Allah; El-Masry, Muhammad Abbas

doi:10.1007/s10620-023-08049-2

Cited by 3 publications

(1 citation statement)

References 25 publications

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“…CTSI is a radiological scoring system based on CT scan results, designed to objectively quantify the severity of pancreatic inflammation, the presence of pancreatic necrosis, and extrapancreatic complications. Several studies have reported on the potential value of CTSI in predicting the severity and prognosis of AP [5][6][7]. However, the combined effect of CTSI with clinical parameters has not been sufficiently studied.…”

Section: Introductionmentioning

confidence: 99%

Construction and alidation of a severity prediction model for acute pancreatitis based on CT severity index: A retrospective case-control study

Han,

Hu,

et al. 2024

PLoS ONE

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To construct and internally and externally validate a nomogram model for predicting the severity of acute pancreatitis (AP) based on the CT severity index (CTSI).A retrospective analysis of clinical data from 200 AP patients diagnosed at the Hefei Third Clinical College of Anhui Medical University from June 2019 to June 2022 was conducted. Patients were classified into non-severe acute pancreatitis (NSAP, n = 135) and severe acute pancreatitis (SAP, n = 65) based on final clinical diagnosis. Differences in CTSI, general clinical features, and laboratory indicators between the two groups were compared. The LASSO regression model was used to select variables that might affect the severity of AP, and these variables were analyzed using multivariate logistic regression. A nomogram model was constructed using R software, and its AUC value was calculated. The accuracy and practicality of the model were evaluated using calibration curves, Hosmer-Lemeshow test, and decision curve analysis (DCA), with internal validation performed using the bootstrap method. Finally, 60 AP patients treated in the same hospital from July 2022 to December 2023 were selected for external validation.LASSO regression identified CTSI, BUN, D-D, NLR, and Ascites as five predictive factors. Unconditional binary logistic regression analysis showed that CTSI (OR = 2.141, 95%CI:1.369–3.504), BUN (OR = 1.378, 95%CI:1.026–1.959), NLR (OR = 1.370, 95%CI:1.016–1.906), D-D (OR = 1.500, 95%CI:1.112–2.110), and Ascites (OR = 5.517, 95%CI:1.217–2.993) were independent factors influencing SAP. The established prediction model had a C-index of 0.962, indicating high accuracy. Calibration curves demonstrated good consistency between predicted survival rates and actual survival rates. The C-indexes for internal and external validation were 0.935 and 0.901, respectively, with calibration curves close to the ideal line.The model based on CTSI and clinical indicators can effectively predict the severity of AP, providing a scientific basis for clinical decision-making by physicians.

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Section: Introductionmentioning

confidence: 99%

Construction and alidation of a severity prediction model for acute pancreatitis based on CT severity index: A retrospective case-control study

Han,

Hu,

et al. 2024

PLoS ONE

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SIRT5 mediated succinylation of SUCLA2 regulates TCA cycle dysfunction and mitochondrial damage in pancreatic acinar cells in acute pancreatitis

Liu,

Wang,

et al. 2025

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Research Progress on Predicting the Severity and Prognosis of Acute Pancreatitis

李

2024

ACM

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Mitochondrial DNA Copy Number, a Damage-Associated Molecular Pattern Molecule, Can Predict Pancreatic Necrosis and Is Correlated with the Severity of Acute Pancreatitis

Cited by 3 publications

References 25 publications

Construction and alidation of a severity prediction model for acute pancreatitis based on CT severity index: A retrospective case-control study

Construction and alidation of a severity prediction model for acute pancreatitis based on CT severity index: A retrospective case-control study

SIRT5 mediated succinylation of SUCLA2 regulates TCA cycle dysfunction and mitochondrial damage in pancreatic acinar cells in acute pancreatitis

Research Progress on Predicting the Severity and Prognosis of Acute Pancreatitis

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