Mitochondrial DNA copy number as a diagnostic marker and indicator of degree of severity in alopecia areata

Shehata, Wafaa Ahmed; Hammam, M. A.; Abdo, Aya; Tayel, Nermin; Abdelsattar, Shimaa

doi:10.1080/15321819.2023.2168557

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…Such stressors result in increased mitochondrial biogenesis to prevent genomic instability [ 59 ]. A recent study investigating the diagnostic role of mtDNA copy number in alopecia areata patients found significantly elevated mtDNA copy number among cases, highlighting its potential use in diagnosing and evaluating alopecia severity [ 60 ]. In addition, another study found an increased mtDNA copy number in patients with vitiligo compared to healthy controls [ 61 ].…”

Section: Mitochondria Dysfunction and Dermatological Manifestationsmentioning

confidence: 99%

Dermatologic Manifestations of Mitochondrial Dysfunction: A Review of the Literature

Natarelli,

Gahoonia,

Aflatooni

et al. 2024

IJMS

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Mitochondria are eukaryotic cellular organelles that function in energy metabolism, ROS production, and programmed cell death. Cutaneous epithelial and hair follicle dermal papilla cells are energy-rich cells that thereby may be affected by mitochondrial dysfunction and DNA mutation accumulation. In this review, we aimed to summarize the medical literature assessing dermatologic conditions and outcomes associated with mitochondrial dysfunction. A search of PubMed and Embase was performed with subsequent handsearching to retrieve additional relevant articles. Mitochondrial DNA (mtDNA) deletions, mutation accumulation, and damage are associated with phenotypic signs of cutaneous aging, hair loss, and impaired wound healing. In addition, several dermatologic conditions are associated with aberrant mitochondrial activity, such as systemic lupus erythematosus, psoriasis, vitiligo, and atopic dermatitis. Mouse model studies have better established causality between mitochondrial damage and dermatologic outcomes, with some depicting reversibility upon restoration of mitochondrial function. Mitochondrial function mediates a variety of dermatologic conditions, and mitochondrial components may be a promising target for therapeutic strategies.

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Section: Mitochondria Dysfunction and Dermatological Manifestationsmentioning

confidence: 99%

Dermatologic Manifestations of Mitochondrial Dysfunction: A Review of the Literature

Natarelli,

Gahoonia,

Aflatooni

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

Concurrent detection of the mitochondrial DNA copy number and the +35G/C polymorphism in the mitochondrial transcription factor A gene in endometriosis

El Derbaly,

Mohamed,

Ghanaym

et al. 2024

Archives of Biochemistry and Biophysics

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Mitochondrial DNA copy number as a diagnostic marker and indicator of degree of severity in alopecia areata

Cited by 2 publications

References 34 publications

Dermatologic Manifestations of Mitochondrial Dysfunction: A Review of the Literature

Dermatologic Manifestations of Mitochondrial Dysfunction: A Review of the Literature

Concurrent detection of the mitochondrial DNA copy number and the +35G/C polymorphism in the mitochondrial transcription factor A gene in endometriosis

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