Mitochondrial DNA evolution in lagomorphs: Origin of systematic heteroplasmy and organization of diversity in European rabbits

Biju-Duval, C.; Ennafaa, Hajer; Dennebouy, N.; Monnerot, Monique; Mignotte, Françoise; Soriguer, Ramón C.; Gaaied, Amel El; Hili, Ali El; Mounolou, Jean‐Claude

doi:10.1007/bf02100200

Cited by 109 publications

(74 citation statements)

References 29 publications

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“…This, along with a well-documented history, has allowed the development of multiple studies on the evolutionary history of this lagomorph from a wide range of molecular (Ferrand, 1989;Biju-Duval et al, 1991;Branco, Ferrand & Monnerot, 2000;Geraldes et al, 2008;Carneiro et al, 2012), temporal Monnerot et al, 1994) and geographical perspectives (Webb et al, 1995;Fuller, Wilson & Mather, 1997;Surridge et al, 1999b;Queney et al, 2000;Queney et al, 2001;Branco et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…algirus (Loche 1867) inhabiting the southwest of the Iberian Peninsula, and lineage B, which predominates in O. c. cuniculus in the northeast of the Peninsula (Biju-Duval et al, 1991). It is proposed that mitochondrial lineages A and B diverged following isolation in two glacial refugia in the southwestern and northeastern extremes of the Iberian Peninsula, likely during the Quaternary paleoclimatic oscillations.…”

Section: Introductionmentioning

confidence: 99%

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Spatial genetic structure across a hybrid zone between European rabbit subspecies

Alda

Doadrio

2014

Preprint

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View the peer-reviewed version (peerj.com/articles/582), which is the preferred citable publication unless you specifically need to cite this preprint.Alda F, Doadrio I. 2014. Spatial genetic structure across a hybrid zone between European rabbit subspecies. PeerJ 2:e582 https://doi.org/10.7717/peerj.582 S p a t i a l g e n e t i c s t r u c t u r e a c r o s s a h y b r i d z o n e b e t we e n E u r o p e a n r a b b i t s u b s p e c i e sT h e I b e r i a n P e n i n s u l a i s t h e o n l y r e g i o n i n t h e wo r l d wh e r e t h e t wo e x i s t i n g s u b s p e c i e s o f t h e E u r o p e a n r a b b i t ( Or y c t o l a g u s c u n i c u l u s ) n a t u r a l l y o c c u r a n d h y b r i d i z e . I n t h i s s t u d y we e x p l o r e t h e r e l a t i v e r o l e s o f h i s t o r i c a l a n d c o n t e mp o r a r y p r o c e s s e s i n s h a p i n g t h e s p a t i a l g e n e t i c s t r u c t u r e o f t h e r a b b i t a c r o s s i t s n a t i v e d i s t r i b u t i o n r a n g e , a n d h o w t h e y d i ff e r e n t l y a ff e c t e a c h s u b s p e c i e s a n d t h e h y b r i d z o n e . F o r t h a t p u r p o s e mu l t i l o c u s g e n o t y p e s a n d mi t o c h o n d r i a l DNA d a t a we r e o b t a i n e d f o r 7 7 1 r a b b i t s a c r o s s mo s t o f t h e s p e c i e s ' d i s t r i b u t i o n r a n g e i n S p a i n . Nu c l e a r ma r k e r s d e fi n e d a h i e r a r c h i c a l g e n e t i c s t r u c t u r e fi r s t l y c o mp r i s e d b y t wo g e n e t i c g r o u p s , l a r g e l y c o n g r u e n t wi t h t h e mi t o c h o n d r i a l l i n e a g e s a n d s u b s p e c i e s d i s t r i b u t i o n s ( O. c . a l g i r u s a n d O. c . c u n i c u l u s ) , wh i c h we r e s u b s e q u e n t l y s u b d i v i d e d i n t os e v e n g e n e t i c g r o u p s p r o b a b l y s h a p e d b y e n v i r o n me n t a l o r e c o l o g i c a l f a c t o r s . Ge o g r a p h i c d i s t a n c e a l o n e e me r g e d a s a n i mp o r t a n t f a c t o r e x p l a i n i n g g e n e t i c d i ff e r e n t i a t i o n a c r o s s t h e wh o l e r a n g e , wi t h o u t t h e n e e d t o i n v o k e f o r t h e e ff e c t f o r g e o g r a p h i c a l b a r r i e r s . T h u s , wh e n c o n s i d e r i n g t h e o v e r a l l g e n e t i c s t r u c t u r e , d i ff e r e n c e s a t a l o c a l l e v e l s e e m t o b e o f g r e a t e r i mp o r t a n c e . T h e s i g n i fi c a n t l y p o s i t i v e s p a t i a l c o r r e l a t i o n u p t o a d i s t a n c e o f o n l y 1 0 0 k m s u p p o r t e d t h i s h y p o t h e s i s . Ho we v e r , n o r t h e r n p o p u l a t i o n s o f O. c . c u n i c u l u s s h o we d mo r e s p a t i a l g e n e t i c s t r u c t u r e a n d d i ff e r e n t i a t i o n t h a n O. c . a l g i r u s , wh i c h c o u l d b e d u e t o l o c a l g e o g r a p h i c b a r r i e r s , l i mi t e d r e s o u r c e s , s o i l t y p e a n d / o r s o c i a l b e h a v i o u r s l i mi t i n g d i s p e r s a l .T h e h y b r...

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Spatial genetic structure across a hybrid zone between European rabbit subspecies

Alda

Doadrio

2014

Preprint

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“…The European rabbit comprises two distinct subspecies that are parapatrically distributed across the Iberian Peninsula: Oryctolagus cuniculus algirus, present in the southwest of Iberia, and Oryctolagus cuniculus cuniculus, which occurs in the northeast of Iberia (Biju-Duval et al, 1991;Branco et al, 2000). The two subspecies diverged in allopatry roughly 2 million years ago during the Quaternary glaciations (Biju-Duval et al, 1991;Geraldes et al, 2006) and have since come back into secondary contact, establishing a hybrid zone in central Iberia (Branco et al, 2002;Geraldes et al, 2005;Ferrand and Branco, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…The two subspecies diverged in allopatry roughly 2 million years ago during the Quaternary glaciations (Biju-Duval et al, 1991;Geraldes et al, 2006) and have since come back into secondary contact, establishing a hybrid zone in central Iberia (Branco et al, 2002;Geraldes et al, 2005;Ferrand and Branco, 2007). Both hybrid and parental Iberian populations have been extensively characterized by different types of markers, such as allozymes , mitochondrial DNA (mtDNA) (Branco et al, 2000(Branco et al, , 2002 and X-and Ychromosomes (Geraldes et al, 2006(Geraldes et al, , 2008, that are concordant in placing the centre of the hybrid zone in the central region of Iberia, though not associated to any ecological or physical transition.…”

Section: Introductionmentioning

confidence: 99%

Copy number polymorphism in the α-globin gene cluster of European rabbit (Oryctolagus cuniculus)

2011

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Comparative genomic studies have revealed that mammals typically possess two or more tandemly duplicated copies of the a-globin (HBA) gene. The domestic rabbit represents an exception to this general rule, as this species was found to possess a single HBA gene. Previous electrophoretic surveys of HBA polymorphism in natural populations of the European rabbit (Oryctolagus cuniculus) revealed extensive geographic variation in the frequencies of three main electromorphs. The variation in frequency of two electromorphs is mainly partitioned between two distinct subspecies of European rabbit, and a third is restricted to the hybrid zone between the two rabbit subspecies in Iberia. Here we report the results of a survey of nucleotide polymorphism, which revealed HBA copy number polymorphism in Iberian populations of the European rabbit. By characterizing patterns of HBA polymorphism in populations from the native range of the European rabbit, we were able to identify the specific amino-acid substitutions that distinguish the previously characterized electromorphs. Within the hybrid zone, we observed the existence of a second HBA gene duplicate, named HBA2, that mostly represents a novel sequence haplotype, which occurs in higher frequency within the hybrid zone, and thus appears to have arisen in hybrids of the two distinct subspecies. Although this novel gene is also present in other wild Iberian populations, it is almost absent from French populations, which suggest a recent ancestry, associated with the establishment of the post-Pleistocene contact zone between the two European rabbit subspecies.

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“…Biju-Duval et al [1] first showed the occurrence of two highly divergent mtDNA lineages in Iberian wild rabbit populations by using RFLP of the whole molecule and tentatively dated their divergence at 1-2 million years ago. Later, Branco et al [2,3] described phylogeographical evidence for a recent contact zone bisecting the Iberian Peninsula from the Northwest to the Southeast and suggested that postglacial population expansions from two different refugia could explain the observed patterns.…”

Section: Introductionmentioning

confidence: 99%

A 7-bp insertion in the 3' untranslated region suggests the duplication and concerted evolution of the rabbitSRYgene

Geraldes

Ferrand

2006

Genet. Sel. Evol.

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-In this work we report the genetic polymorphism of a 7-bp insertion in the 3' untranslated region of the rabbit SRY gene. The polymorphic GAATTAA motif was found exclusively in one of the two divergent rabbit Y-chromosomal lineages, suggesting that its origin is more recent than the separation of the O. c. algirus and O. c. cuniculus Y-chromosomes. In addition, the remarkable observation of haplotypes exhibiting 0, 1 and 2 7-bp inserts in essentially all algirus populations suggests that the rabbit SRY gene is duplicated and evolving under concerted evolution. rabbit / SRY gene / polymorphic insertion / duplication / concerted evolution

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Mitochondrial DNA evolution in lagomorphs: Origin of systematic heteroplasmy and organization of diversity in European rabbits

Cited by 109 publications

References 29 publications

Spatial genetic structure across a hybrid zone between European rabbit subspecies

Spatial genetic structure across a hybrid zone between European rabbit subspecies

Copy number polymorphism in the α-globin gene cluster of European rabbit (Oryctolagus cuniculus)

A 7-bp insertion in the 3' untranslated region suggests the duplication and concerted evolution of the rabbitSRYgene

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