Mitochondrial Dysfunction and Oxidative Stress: Focusing on Cardiac Hypertrophy and Heart Failure

Katare, Parmeshwar B.; Nizami, Hina Lateef; Banerjee, Sanjay K.

doi:10.1007/978-981-13-8273-4_25

Cited by 1 publication

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“…Currently, attention is focused on oxidative stress, as one of the main determinants of endothelial dysfunction in cardiovascular disease. The main reason for all the negative effects of glucocorticoids is that dexamethasone induces excessive production of reactive oxygen species, causing dysregulation of physiological processes [1,6,7].…”

Section: Introductionmentioning

confidence: 99%

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Changes of lipid oxidation products content in ventricles of the rat heart as a result of electrolyte-steroid cardiomyopathy and correction of this condition

Sverediuk¹,

Pelykh²

2020

J Educ Health Sport

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Cardiovascular disease is one of the leading causes of death in the world. One of such pathologies is metabolic cardiomyopathy. This pathology includes dysfunction of amino acids, lipids, mitochondria, and disease of products accumulation. Conditions that can cause such changes include congenital and acquired hormone levels. A good example is the longterm use of dexamethasone for the treatment of patients with allergies or rheumatology diseases. Electrolyte disturbances are often a concomitant consequence of disease or lifestyle. They also contribute to heart damage under these conditions. Cell damage often begins with damage to cell lipid membranes and is accompanied by accumulation of lipid peroxidation products. The purpose of our study was to investigate diene, triene conjugates and thiobarbituric acid reactive substances levels in the animal ventriculs heart tissue of both sex in conditions of long-term action of dexamethasone and high concentration (4%) solution of 273 sodium chloride in drink water. L-carnitine, as an antioxidant and having the ability to influence to energetic metabolism, apoptosis and transcription of DNA may be a promising means for correction disorders. The experiment was performed with the use of 96 mature white nonlinear rats. Dexamethasone with long-term use promotes the accumulation of diene, triene conjugates and thiobarbituric acid reactive substances (malondialdehyde is main) in the ventricular myocardium of rats of both sexes, more in animals with high content (4%) of NaCl in drinking water, and in males, compared with females. L-carnitine has the ability to significantly offset the negative effects of dexamethasone on the content of lipoperoxidation products in the ventricular myocardium of rats of both sexes, including against the background of increased salt content in drinking water.

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Section: Introductionmentioning

confidence: 99%

“…Since the production of reactive oxygen species in mitochondria occurs during the transport of electrons to molecular oxygen in the respiratory chain, the influx of electrons due to excessive oxidation of fatty acids contributes to their additional formation in the myocardium [6].…”

Section: Introductionmentioning

confidence: 99%

Changes of lipid oxidation products content in ventricles of the rat heart as a result of electrolyte-steroid cardiomyopathy and correction of this condition

Sverediuk¹,

Pelykh²

2020

J Educ Health Sport

View full text Add to dashboard Cite

show abstract

Mitochondrial Dysfunction and Oxidative Stress: Focusing on Cardiac Hypertrophy and Heart Failure

Cited by 1 publication

References 108 publications

Changes of lipid oxidation products content in ventricles of the rat heart as a result of electrolyte-steroid cardiomyopathy and correction of this condition

Changes of lipid oxidation products content in ventricles of the rat heart as a result of electrolyte-steroid cardiomyopathy and correction of this condition

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