Mitochondrial Localization and Function of the Purinergic Receptor P2X7

Kroemer, Guido; Verkhratsky, Alexei

doi:10.1093/function/zqab006

Cited by 3 publications

(3 citation statements)

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“…These receptors are linked to Complex I via an undiscovered cascade mechanism. 48 When activated, P2X7 receptors enhance the expression and function of Complex I, thereby boosting mitochondrial polarization. This polarization increases ionized Ca 2+ levels within the matrix and increases ATP production.…”

Section: Mitochondrial Function In Synaptic Transmissionmentioning

confidence: 99%

“… 49 P2X synapse receptors exhibit a higher calcium permeability than glutamate ionotropic receptors. 48 , 50 This heightened calcium influx through P2X receptors holds significant sway over synaptotoxicity, potentially surpassing the impact of glutamate signaling. Consequently, pathological alterations in mitochondrial function could result from this excitotoxic neuronal injury.…”

Section: Mitochondrial Function In Synaptic Transmissionmentioning

confidence: 99%

See 1 more Smart Citation

Mitochondrial plasticity and synaptic plasticity crosstalk; in health and Alzheimer's disease

Sayehmiri,

Motamedi,

Batool

et al. 2024

CNS Neurosci Ther

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Synaptic plasticity is believed to underlie the cellular and molecular basis of memory formation. Mitochondria are one of the main organelles involved in metabolism and energy maintenance as plastic organelles that change morphologically and functionally in response to cellular needs and regulate synaptic function and plasticity through multiple mechanisms, including ATP generation, calcium homeostasis, and biogenesis. An increased neuronal activity enhances synaptic efficiency, during which mitochondria's spatial distribution and morphology change significantly. These organelles build up in the pre‐and postsynaptic zones to produce ATP, which is necessary for several synaptic processes like neurotransmitter release and recycling. Mitochondria also regulate calcium homeostasis by buffering intracellular calcium, which ensures proper synaptic activity. Furthermore, mitochondria in the presynaptic terminal have distinct morphological properties compared to dendritic or postsynaptic mitochondria. This specialization enables precise control of synaptic activity and plasticity. Mitochondrial dysfunction has been linked to synaptic failure in many neurodegenerative disorders, like Alzheimer's disease (AD). In AD, malfunctioning mitochondria cause delays in synaptic vesicle release and recycling, ionic gradient imbalances, and mostly synaptic failure. This review emphasizes mitochondrial plasticity's contribution to synaptic function. It also explores the profound effect of mitochondrial malfunction on neurodegenerative disorders, focusing on AD, and provides an overview of how they sustain cellular health under normal conditions and how their malfunction contributes to neurodegenerative diseases, highlighting their potential as a therapeutic target for such conditions.

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Section: Mitochondrial Function In Synaptic Transmissionmentioning

confidence: 99%

Section: Mitochondrial Function In Synaptic Transmissionmentioning

confidence: 99%

Mitochondrial plasticity and synaptic plasticity crosstalk; in health and Alzheimer's disease

Sayehmiri,

Motamedi,

Batool

et al. 2024

CNS Neurosci Ther

View full text Add to dashboard Cite

show abstract

“…Seven subtypes of ionotropic P2X receptors and eight subtypes of metabotropic P2Y receptors are known ( White and Burnstock, 2006 ). The structural features of purinergic receptors, the architecture of the subunits of homomeric and heteromeric channels, and signal transduction mechanisms are presented in several reviews ( Piirainen et al, 2011 ; Compan, 2012 ; Hattori and Gouaux, 2012 ; Baroja-Mazo et al, 2013 ; North, 2016 ; Kroemer and Verkhratsky, 2021 ; Sarti et al, 2021 ). The structural and schematic models of P2X7 receptor, the most studied member of P2X receptors family, are presented in Figure 1 .…”

Section: The Concept Of Purinergic Signaling and Mitochondrial Physio...mentioning

confidence: 99%