Mitochondrial quality control in abdominal aortic aneurysm: From molecular mechanisms to therapeutic strategies

Abstract

Mitochondria are the energy supply sites of cells and are crucial for eukaryotic life. Mitochondrial dysfunction is involved in the pathogenesis of abdominal aortic aneurysm (AAA). Multiple mitochondrial quality control (MQC) mechanisms, including mitochondrial DNA repair, biogenesis, antioxidant defense, dynamics, and autophagy, play vital roles in maintaining mitochondrial homeostasis under physiological and pathological conditions. Abnormalities in these mechanisms may induce mitochondrial damage and dysfunction leading to cell death and tissue remodeling. Recently, many clues suggest that dysregulation of MQC is closely related to the pathogenesis of AAA. Therefore, specific interventions targeting MQC mechanisms to maintain and restore mitochondrial function have become promising therapeutic methods for the prevention and treatment of AAA.

Mitochondrial Dynamics in Neurodegenerative Diseases: Unraveling the Role of Fusion and Fission Processes

“…Elaborating on this concept, Wang et al illuminated the synergistic interplay and interconnectedness inherent in the mechanisms governing mitochondrial quality control across diverse cellular pathways [64]. They propose that any disruption introduced to a single cellular pathway can induce cascading effects throughout the cellular network, thereby exerting an impact on fundamental processes like mitochondrial fusion and fission.…”