Mitochondrial remodeling in differentiating neuroblasts

Voccoli, Vladimir; Colombaioni, Laura

doi:10.1016/j.brainres.2008.11.026

Cited by 37 publications

(33 citation statements)

References 45 publications

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“…Mitochondria may play a role in stem cell proliferation by reducing mitochondrial oxygen levels, a phenomenon that enhances both ESC and NSC proliferation and differentiation potential [257][258][259], and by reducing mitochondrial Ca 2? levels, that are increased, along with mitochondrial fusion, during neuronal differentiation [260]. Loss of normal mitochondrial function may also contribute to the observed decrease in proliferation in the PINK1 KD experiments.…”

Section: Pink1 (Park6)mentioning

confidence: 88%

Neural stem cells in Parkinson’s disease: a role for neurogenesis defects in onset and progression

Grand

Gonzalez-Cano

Pavlou

et al. 2014

Cell. Mol. Life Sci.

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Parkinson's disease (PD) is the second most common neurodegenerative disorder, leading to a variety of motor and non-motor symptoms. Interestingly, nonmotor symptoms often appear a decade or more before the first signs of motor symptoms. Some of these non-motor symptoms are remarkably similar to those observed in cases of impaired neurogenesis and several PD-related genes have been shown to play a role in embryonic or adult neurogenesis. Indeed, animal models deficient in Nurr1, Pitx3, SNCA and PINK1 display deregulated embryonic neurogenesis and LRRK2 and VPS35 have been implicated in neuronal development-related processes such as Wnt/bcatenin signaling and neurite outgrowth. Moreover, adult neurogenesis is affected in both PD patients and PD animal models and is regulated by dopamine and dopaminergic (DA) receptors, by chronic neuroinflammation, such as that observed in PD, and by differential expression of wild-type or mutant forms of PD-related genes. Indeed, an increasing number of in vivo studies demonstrate a role for SNCA and LRRK2 in adult neurogenesis and in the generation and maintenance of DA neurons. Finally, the roles of PDrelated genes, SNCA, LRRK2, VPS35, Parkin, PINK1 and DJ-1 have been studied in NSCs, progenitor cells and induced pluripotent stem cells, demonstrating a role for some of these genes in stem/progenitor cell proliferation and maintenance. Together, these studies strongly suggest a link between deregulated neurogenesis and the onset and progression of PD and present strong evidence that, in addition to a neurodegenerative disorder, PD can also be regarded as a developmental disorder.

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Section: Pink1 (Park6)mentioning

confidence: 88%

Neural stem cells in Parkinson’s disease: a role for neurogenesis defects in onset and progression

Grand

Gonzalez-Cano

Pavlou

et al. 2014

Cell. Mol. Life Sci.

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“…To examine this possibility, part of samples were dyed with JC-1, a cationic dye that enters mitochondria in proportion to the membrane potential forms J-aggregates at higher membrane potentials. 19 As presented in Figure 4A, pollen tubes cultured in control conditions displayed mostly two populations of mitochondria: some mitochondria (both ellipsoid and filamentous mitochondria) with only green fluorescence and others (mainly rod-like) with reddish orange, even red fluorescence. Surprisingly, the two types of mitochondria also showed polarized organization.…”

Section: Effects Of Mg132 Treatment On Mitochondrial Membrane Potentialsmentioning

confidence: 89%

“…Emerging information obtained mainly from yeast and mammalian cells indicates that mitochondria vary considerably depending on specific cell type and organism with shapes ranging from oval to spherical to elongated worm-like or even branch-like structures. [19][20][21] Our current knowledge of mitochondrial morphology in higher plant, especially in gymnosperm pollen tubes, is mainly based on experiments with TEM. These microscopes can provide high-spatial resolution of mitochondrial two-dimensional ultrastructure, but the third dimension is lost and shows static and usually classic textbook oval structures.…”

Section: Discussionmentioning

confidence: 99%

“…Thus our data are consistent, and confirm previous reports that mitochondria are highly dynamic organelles with various morphologies regulated by adjusting the balance between the opposite processes of fusion and fission. [11][12][13][14][19][20][21] Mitochondrial dynamics may have diverse and essential functions in cell physiology. It was reported that the mitochondria of rat liver, cardiac muscle, and diaphragm proteasome and mitochondria in pollen tubesskeletal muscle are isolated ellipses or tubules in embryonic stages but then convert into smooth filaments or reticular networks in the adult.…”

Section: Discussionmentioning

confidence: 99%

“…18,19 Thus, we speculated that MG132 treatment might also have effects on mitochondrial membrane potentials. To examine this possibility, part of samples were dyed with JC-1, a cationic dye that enters mitochondria in proportion to the membrane potential forms J-aggregates at higher membrane potentials.…”

Section: Effects Of Mg132 Treatment On Mitochondrial Membrane Potentialsmentioning

confidence: 99%

See 2 more Smart Citations

Mitochondrial dynamics and its responds to proteasome defection during Picea wilsonii pollen tube development

Sheng

Dong

Zhang

et al. 2010

Cell Biochemistry & Function

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Tip growth of pollen tubes is essential for higher plant sexual reproduction and has been proposed to be highly regulated by the ubiquitin/proteasome pathway (UPP). The dynamics of mitochondria and the functions of the UPP on mitochondrial dynamics during pollen tube development are still poorly understood. In the present study, using real-time laser scanning and transmission electron microscope, it was revealed that mitochondria in Picea wilsonii, are either ellipsoid or filamentous with various lengths. Time-lapse images indicated that the two forms of mitochondria interconvert frequently through opposite process of fusion and fission. Examination of mitochondrial morphology during four key stages of in vitro pollen tube development revealed a link between mitochondrial remodeling and the process of pollen tube elongation. We also report that MG132, a specific proteasome inhibitor, not only strongly disturbed the mitochondrial remodeling but also significantly reduced mitochondrial membrane potential during pollen tube development. This finding provides new insight into the function of the proteasome in tip growth of pollen tubes.

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Fluorescent Genetically Encoded Calcium Indicators and Their In Vivo Application

Gensch¹,

Kaschuba²

2011

Springer Series on Fluorescence

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Mitochondrial remodeling in differentiating neuroblasts

Cited by 37 publications

References 45 publications

Neural stem cells in Parkinson’s disease: a role for neurogenesis defects in onset and progression

Neural stem cells in Parkinson’s disease: a role for neurogenesis defects in onset and progression

Mitochondrial dynamics and its responds to proteasome defection during Picea wilsonii pollen tube development

Fluorescent Genetically Encoded Calcium Indicators and Their In Vivo Application

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