Mitochondrial Replacement Therapy: Future or Present?

Abstract

In this review, conducted according to world literature, we sought to determine the role of mitochondrial DNA (mtDNA) in the formation of mitochondrial diseases. To determine the availability of treatment methods for hereditary diseases, in particular those associated with mitochondrial diseases, and to assess the role of mitochondrial replacement therapy (MRT) in assisted reproductive technologies.
 The scientific articles corresponding to the chosen goal are published on MEDLINE, EMBASE, in the Cochrane Library, PubMed, and other information sources.
 The search strategy combined the following search terms “mitochondrial diseases,” “mitochondrial replacement therapy,” “three-parent baby,” “ART,” “genetic engineering”.