Mitochondrial Transplantation: A Unique Treatment Strategy

Abstract

:Mitochondrial transplantation (MT) refers to the process of introducing isolated mitochondria into a damaged area of the heart or other organs. In the past decade, this technique has been continuously updated as the fundamental research on the repair of damaged cells or tissues. In particular, in the field of heart protection from ischemia–reperfusion injury, the MT therapy has been developed to the clinical trial stage. Generally speaking, the goal of therapeutic intervention is to replace damaged mitochondria or increase the transfer of mitochondria between cells so as to improve mitochondrial dysfunction. In this review, we summarized the studies on MT conducted at different time nodes and outlined a range of different methods for delivering mitochondria into the target site. Finally, we described the applications of MT in different diseases and discussed the clinical studies of human MT currently in progress and the problems that need to be overcome. We hope to provide new ideas for the treatment of mitochondrial defect–related diseases.

Mitochondrial Transplantation Alleviates Doxorubicin-Induced Toxicity in Rat Renal Cells

“…Nowadays, researchers have been investigating the use of mitochondrial transplantation as a new treatment approach for mitochondrial disorders. In this approach, healthy exogenous mitochondria are transferred to damaged cells (48)(49)(50).…”

Las mitocondrias: sus funciones, las relaciones con otros organelos, la supervivencia celular y la medicina mitocondrial

“…Los estudios han mostrado que las mitocondrias de una célula sana se transfieren a una célula que está bajo condiciones no favorables, como en un proceso cancerígeno o, como se mencionó, en estrés oxidante (Chen, Zhong, Wang & Chen, 2021;Zhou et al, 2022;Hosseinian, Ali Pour & Kheradvar, 2022).…”

Mitokondri Nakli ve Transferi, geçmişten gelecek beklentilere

“…Although this functional change occurs during ischemia, an increase is also observed during restoration of myocardial blood flow and oxygen distribution to the tissue. It is known that this condition shortens the contractions and lifetimes of myocardium (1).…”

“…Mitochondria are unique structures that can be called energy units for cells, in addition to meeting the energy needed by the body through mitochondrial electron transport chains and oxidative phosphorylation. It can be said that the organelle plays a central role between pathological and physiological issues in terms of associating processes such as homeostasis and energy metabolism in normal tissue with issues such as neurodegeneration and immunity (1).…”