Mitofaji ve Obezite

Abstract

Overfed and high-fat diets lead to many metabolic changes such as deterioration in energy homeostasis and aerobic respiration, increase ROS (reactive oxygen species) products, and inflammation status in obesity. Obesity-mediated occurred oxidative stress and low-level chronic inflammation can result in impaired mitochondrial homeostasis, which has been involved in the pathophysiological of metabolic syndrome-related diseases such as Type 2 Diabetes Mellitus. The mitochondria organelle plays an effective role in energy and calcium homeostasis, cell metabolism, and even cancer cell metabolism. Mitophagy known as a mitochondrial-recover operation has been thought as a critical factor in supporting mitochondrial hemostasis, which can make a great contribution to recovery from cellular abnormalities in obese patients. This review's aim is to ensure a current and comprehensive summary of the role of developing mitochondrialrelated dysfunction and protective effect of mitophagy in the pathophysiology of obesity.