Mitomycin C in ophthalmology

Mitomycin-C Use and Complications in Ophthalmology

“…Mitomycin-C should be reconstituted in sterile water at neutral pH, the drug is inactivated in an acidic solution. The drug should be stored under refrigeration to preserve its potency under these conditions, Mitomycin-C is potent for a period of two weeks [3].…”

“…The drug is available in a vial (2mg/ml and 10mg/ml). It is further reconstituted with normal saline either 5 ml for 2 mg/ml vial to make 0.4 mg/ml solution or 10 ml for 2 mg/ml vial to make 0.2 mg/ml solution [3]. MMC is delivered in solubilized form.…”

“…Photophobia, ocular pain, lacrimation, foreign body sensation (secondary to super icial punctate keratitis) and eye lid edema are cauntable as minor comlications of topical Mitomycin-C [3]. Scleral and corneal ulceration and perforation, hypotony, necrotizing scleritis, endophthalmitis, iridocyclitis, cataract, glaucoma and symblepharon are rare and major complications of topical Mitomycin-C [3].…”

“…One-eyed patients, pregnant women, very old patients, severe dry eye, those with predisposing condition to corneal ulceration or poor healing such as immunocompromised patients or patients with Sjogren's syndrome, atopic keratoconjunctivitis, acne rosacea or herpetic keratitis [3].…”

History, presence, and future of mitomycin C in glaucoma filtration surgery

“…Currently, intraoperative MMC administration in the sub-Tenon's space with a sponge soaked in MMC is the gold standard antifibrotic treatment in GFS [8,9]. Additionally, the use and application of MMC in ophthalmology, especially in glaucoma procedures, has been increasing in recent years, because of its modulatory effects on wound healing [18]. Unfortunately, MMC administration does not completely prevent failures of current GFS procedures.…”