Mitotic activity and prognosis in prostatic adenocarcinoma

Vesalainen, S; Talja, Martti; Lipponen, P; Syrjänen, Karí

doi:10.1002/pros.2990260204

Cited by 31 publications

(31 citation statements)

References 22 publications

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“…The perineural growth was categorized into two groups; present or absent. The mitotic figures were identified and calculated from the most actively proliferating area in the section (Vesalainen et al, 1995). The volume corrected mitotic index method (M/V index) was used, which expresses the number of mitotic figures/square millimetre of tumour tissue in the section (Vesalainen et al, 1995).…”

Section: Histological Methods and Flow Cytometrymentioning

confidence: 99%

“…The mitotic figures were identified and calculated from the most actively proliferating area in the section (Vesalainen et al, 1995). The volume corrected mitotic index method (M/V index) was used, which expresses the number of mitotic figures/square millimetre of tumour tissue in the section (Vesalainen et al, 1995). The results of flow cytometry have been reported in detail previously (Vesalainen et al, 1994).…”

Section: Histological Methods and Flow Cytometrymentioning

confidence: 99%

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α-Catenin expression has prognostic value in local and locally advanced prostate cancer

et al. 1999

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Normally functioning cell–cell adhesion plays an important role in the maintenance of tissue architecture and cell cohesion. E-cadherin is an important adhesion molecule of epithelial cells. In many types of cancer the expression of E-cadherin is reduced leading to increased risk of disease progression. α-Catenin is one of the intracellular elements of the E-cadherin–catenin complex. The abnormalities in the expression of α-catenin seem to associate with malignant cellular features and disease progression in prostate cancer. To further analyse the significance of α-catenin expression, we studied 215 cases of prostate cancer by immunohistochemistry and the results were related to other known prognostic factors and patient survival during a mean follow-up period of 13 years. α-Catenin expression was down-regulated in 19% of the cases and 3% of the tumours were totally α-catenin-negative. The abnormal α-catenin expression and cytoplasmic signal were significantly linked with high T-category, metastatic disease, high Gleason score, perineural growth, high mitotic rate, high S phase fraction and DNA aneuploidy ( P < 0.05 for all). In the survival analysis, reduced α-catenin expression ( P = 0.06) and cytoplasmic signal ( P = 0.04) were related to unfavourable patient outcome. In the multivariate analysis, including TM-classification and Gleason score, α-catenin expression had independent prognostic value in T1–2 M0 tumors. In the M0 tumours, abnormal α-catenin signal was independently associated with recurrence-free survival as well. The results indicate that down-regulation of α-catenin is related to several malignant cellular features, and it seems to have prognostic significance in the early phases of cancer progression. We suggest that α-catenin expression can provide prognostic information in early prostate cancer. © 1999 Cancer Research Campaign

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Section: Histological Methods and Flow Cytometrymentioning

confidence: 99%

Section: Histological Methods and Flow Cytometrymentioning

confidence: 99%

α-Catenin expression has prognostic value in local and locally advanced prostate cancer

et al. 1999

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“…The mitotic figures were identified and calculated from the most actively proliferating area in the section [3]. The volume–corrected mitotic index method (M/V index) was used, which expresses the number of mitotic figures/mm 2 of tumour tissue in the section [3]. …”

Section: Methodsmentioning

confidence: 99%

“…The earlier studies have revealed that cell proliferation indices and factors related to cell adhesion are important prognostic factors in PC [1, 2, 3]. …”

Section: Introductionmentioning

confidence: 99%

Expression and Prognostic Value of CD44 Standard and Variant v3 and v6 Isoforms in Prostate Cancer

Aaltomaa¹,

Lipponen

Ala‐Opas³

et al. 2001

European Urology

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“…We were specially interested in examining the prognostic value of mitotic indices in gastric cancer because of their powerful prognostic significance in several other human malignancies (Haapasalo et al, 1989;Lipponen et al, 1990;Aaltomaa et al, 1992;Vesalainen et al, 1995).…”

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confidence: 99%

Prognostic factors in gastric cancer: the value of vascular invasion, mitotic rate and lymphoplasmacytic infiltration

Setälä

Kosma²,

Marin³

et al. 1996

Br J Cancer

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Summary A retrospective analysis of 321 gastric cancer patients was made to assess the prognostic value of TNM classification, tumour differentiation, Lauren classification, proliferative rate, inflammatory reaction and tumour invasion in vascular or neural structures of the gastric wall. The TNM classification showed the strongest correlation with survival in univariate and multivariate analyses (P<0.0001). The invasion in lymphatic or vascular system and Lauren classification were also independent prognosticators in multivariate analysis (P<0.05). In univariate analysis, the WHO-grade, the size and the location of the tumour and perinueral invasion were significant prognostic factors (P<0.01), as were the infiltration of lymphocytes and plasma cells in the tumour (P<0.05). On the other hand, the mitotic indices reflecting the proliferative activity of the tumour cells showed no significant correlation with the prognosis. The results indicate that the prognostic power of the TNM classification can be further increased by assessment of the above special histological features in gastric cancer.

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Mitotic activity and prognosis in prostatic adenocarcinoma

Cited by 31 publications

References 22 publications

α-Catenin expression has prognostic value in local and locally advanced prostate cancer

α-Catenin expression has prognostic value in local and locally advanced prostate cancer

Expression and Prognostic Value of CD44 Standard and Variant v3 and v6 Isoforms in Prostate Cancer

Prognostic factors in gastric cancer: the value of vascular invasion, mitotic rate and lymphoplasmacytic infiltration

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