Mitotic Count and the Field of View Area

Meuten, Donald J.; Moore, Frances M.; George, Jeanne W.

doi:10.1177/0300985815593349

Cited by 186 publications

(237 citation statements)

References 11 publications

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“…There were 16 spayed female, two intact female, 19 neutered male and five intact male dogs. Breeds were mixed (n = 11), Labrador retriever, boxer, golden retriever, German shepherd dog, beagle and one each of catahoula, miniature schnauzer, jack russell terrier, flat coated retriever, dachshund, German shorthaired pointer, English bulldog, Cairn terrier, Wheaten terrier, weimaraner, cocker spaniel, English springer spaniel, bichon frise, Australian cattle dog, standard poodle and Maltese.…”

Section: Resultsmentioning

confidence: 99%

“…Pre‐operative cytology was performed in 17 cases. Aspirates were performed of the small intestine, liver, spleen, kidney, pylorus, cecum, bladder, and ureter . A cytologic diagnosis of or suggestive of sarcoma was diagnosed in nine dogs, carcinoma in three dogs, malignant neoplasia in one dog and a non‐diagnostic sample in four dogs.…”

Section: Resultsmentioning

confidence: 99%

“…Abdominal ultrasound was performed preoperatively in 33 dogs. Abdominal ultrasound findings related to the tumour were a mass (29), free abdominal fluid, lymphadenopathy, partial intestinal obstruction and hydroureter/hydronephrosis . A computed tomography scan was performed in one dog and identified a large splenic mass.…”

Section: Resultsmentioning

confidence: 99%

“…Histopathologic evaluation was performed in all dogs. Primary visceral abdominal STSs were found in the spleen, small intestine, liver, pylorus, bladder, and one each in the kidney, cecum and ureter (Table ). There was no difference in survival time when organ of origin was compared ( P = 0.250).…”

Section: Resultsmentioning

confidence: 99%

“…These tumours can arise from any anatomic site; however, they most commonly arise from the skin or subcutaneous tissue. Grading of STSs of the skin and subcutis rely on three major variables: necrosis, differentiation and mitotic count index, which has recently been standardized to mitotic index per 2.37 mm . A cumulative score of these three variables allows for a total tumour score and consistent grading of STSs using a scale of low (grade I), intermediate (grade II) or high (grade III).…”

Section: Introductionmentioning

confidence: 99%

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Outcomes and prognostic variables associated with primary abdominal visceral soft tissue sarcomas in dogs: A Veterinary Society of Surgical Oncology retrospective study

Linden

Liptak²,

Vinayak

et al. 2019

Vet Comparative Oncology

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Primary abdominal visceral soft tissue sarcomas (STSs) are rare tumours in dogs with little information available on outcomes. The goal of this retrospective, multi‐institutional study was to describe the common tumour types, location and prognostic factors associated with primary abdominal visceral STSs. Medical records were searched for dogs with primary abdominal visceral STSs at six institutions and were retrospectively reviewed. Tumours were graded using the previously described grading scheme for STSs of the skin and subcutis when information in the histopathology report contained adequate details. Forty‐two dogs were included in the study. Five dogs had grade I tumours, 11 had grade II and 15 had grade III tumours. The most common tumour type was leiomyosarcoma (38.1%). The most common tumour locations were the spleen (47.6%) and small intestine (23.8%). The local recurrence rate was low (4.7%). Metastasis was present at the time of surgery in 23.8%, and the overall metastatic rate was 40.4%. Mitotic index of ≥9 was associated with significantly shorter survival time (MST 269 days) compared with a mitotic index of <9 (MST not reached). The MST for grade I STSs was not reached, was 589 days for grade II and 158 days for grade III. Dogs with grade III tumours were more likely to develop metastatic disease. Neither location of the primary tumour nor the histologic subtype was associated with survival time. Histologic grading of abdominal visceral STSs using the previously described scheme is prognostic and should be provided on histopathology reports.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%