Mitral annular plane systolic excursion is an easy tool for fibrosis detection by late gadolinium enhancement cardiovascular magnetic resonance imaging in patients with hypertrophic cardiomyopathy

Doesch, Christina; Sperb, Amelie; Sudarski, Sonja; Loßnitzer, Dirk; Rudic, Boris; Tülümen, Erol; Heggemann, Felix; Schimpf, Rainer; Schoenberg, Stefan O.; Borggrefe, Martin; Papavassiliu, Theano

doi:10.1016/j.acvd.2015.01.010

Cited by 13 publications

(17 citation statements)

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“…In the majority of patients, MAPSE can be assessed quite independent of imaging quality [ 4 ]. It requires no special analysis software, can be performed rapidly and shows good inter- and intra-observer variability [ 18 , 29 ]. In cMRI-derived MAPSE measurements, even better intra-and inter-observer reproducibility compared to previous echocardiography studies were obtained [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…The distance between the basal septal mitral annulus (septal MAPSE), the basal lateral mitral annulus (lateral MAPSE) and a reference point outside the left ventricular apex was measured in end-diastole and end-systole. The distance traveled by the septal and lateral annulus from end-diastole to end-systole was calculated as septal and lateral MAPSE by subtracting the left ventricular end-systolic length from the left ventricular end-diastolic length as being described previously [ 18 ]. Average MAPSE was calculated as the average of septal and lateral MAPSE.…”

Section: Methodsmentioning

confidence: 99%

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High sensitivity troponin T and I reflect mitral annular plane systolic excursion being assessed by cardiac magnetic resonance imaging

et al. 2017

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PurposeThis study aims to evaluate the association between high sensitivity troponins (hsTn) and mitral annular plane systolic excursion (MAPSE) in patients undergoing cardiac magnetic resonance imaging (cMRI).MethodsPatients undergoing cMRI were prospectively enrolled. Patients with right ventricular dysfunction (< 50%) were excluded. Blood samples for measurements of hsTn and amino-terminal pro-brain natriuretic peptide (NT-proBNP) were collected at the time of cMRI.Results84 patients were included. Median left ventricular ejection fraction was 59% (IQR 51–64%). HsTn were correlated inversely with MAPSE within multivariable linear regression models (hsTnI: Beta − 0.19; T − 1.96; p = 0.05; hsTnT: Beta − 0.26; T − 3.26; p = 0.002). HsTn increased significantly according to decreasing stages of impaired MAPSE (p < 0.003). HsTn discriminated patients with impaired MAPSE < 11 mm (hsTnT: AUC = 0.67; p = 0.008; hsTnI: AUC = 0.64; p = 0.03) and < 8 mm (hsTnT: AUC = 0.79; p = 0.0001; hsTnI: AUC = 0.75; p = 0.001) and were still significantly associated in multivariable logistic regression models with impaired MAPSE < 11 mm (hsTnT: OR = 4.71; p = 0.002; hsTnI: OR = 4.22; p = 0.009).ConclusionsThis study demonstrates that hsTn are able to reflect MAPSE being assessed by cMRI.Electronic supplementary materialThe online version of this article (doi:10.1186/s40001-017-0281-x) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

High sensitivity troponin T and I reflect mitral annular plane systolic excursion being assessed by cardiac magnetic resonance imaging

et al. 2017

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“…The distance between the basal septal mitral annulus (septal MAPSE), the basal lateral mitral annulus (lateral MAPSE), and a reference point outside the left ventricular apex was measured in end-diastole and end-systole. The distance travelled by the septal and lateral annulus from end-diastole to end-systole was calculated as septal and lateral MAPSE by subtracting the left ventricular end-systolic length (LVESL) from the left ventricular end-diastolic length (LVEDL) as being described previously [5]. Average MAPSE was calculated as the average of septal and lateral MAPSEs.…”

Section: Methodsmentioning

confidence: 99%

“…cMRI allows accurate assessment of cardiac function, perfusion, and vitality under resting and stress-induced circumstances due to its higher three-dimensional resolution [4]. Next to the assessment of left ventricular ejection fraction (LVEF), the so-called mitral annular plane systolic excursion (MAPSE) represents a central functional cMRI parameter reflecting left ventricular function (LVF) [5]. A reduction of MAPSE indicates impaired longitudinal LVF, whereas LVEF reflects both longitudinal and circumferential LV contractility [6].…”

Section: Introductionmentioning

confidence: 99%

Galectin-3 Reflects Mitral Annular Plane Systolic Excursion Being Assessed by Cardiovascular Magnetic Resonance Imaging

et al. 2016

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Background. This study investigates whether serum levels of galectin-3 may reflect impaired mitral annular plane systolic excursion (MAPSE) in patients undergoing cardiac magnetic resonance imaging (cMRI). Methods. Patients undergoing cMRI during routine clinical care were included prospectively within an all-comers design. Blood samples for biomarker measurements were collected within 24 hours following cMRI. Statistical analyses were performed in all patients and in three subgroups according to MAPSE (MAPSE I: ≥11 mm, MAPSE II: ≥8 mm–<11 mm, and MAPSE III: <8 mm). Patients with right ventricular dysfunction (<50%) were excluded. Results. 84 patients were included in the study. Median LVEF was 59% (IQR 51–64%). Galectin-3 correlated significantly with NT-proBNP (r = 0.42, p = 0.0001). Galectin-3 increased significantly according to the different stages of impaired MAPSE (p = 0.006) and was able to discriminate both patients with impaired MAPSE <11 mm (area under the curve (AUC) = 0.645, p = 0.024) and <8 mm (AUC = 0.733, p = 0.003). Combining galectin-3 with NT-proBNP improved discrimination of MAPSE <8 mm (AUC 0.803, p = 0.0001). In multivariable logistic regression models galectin-3 was still associated with impaired MAPSE (MAPSE < 11 mm: odds ratio (OR) = 3.53, p = 0.018; MAPSE < 8 mm: OR = 3.18, p = 0.06). Conclusions. Galectin-3 reflects MAPSE being assessed by cardiac MRI.

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“…Hypertrofisk kardiomyopati er en genetisk sykdom som kan gi omfattende myokardfibrose (37) (figur 4). Fibrose og ledsagende funksjonssvekkelse er ofte størst i basale septum (38). Høyt senopptak av kontrastmiddel ved MR er assosiert med økt risiko for plutselig hjertedød.…”

Section: Hypertrofisk Kardiomyopatiunclassified

Myokardfibrose

Espeland¹,

Lunde²,

Amundsen³

et al. 2018

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Institutt for sirkulasjon og bildediagnostikk Norges teknisk-naturvitenskapelige universitet og Klinikk for hjertemedisin St. Olavs hospital Han har bidratt med idé til artikkelen, utforming/design, datainnsamling, analyse av data, tolking av data, litteratursøk, utarbeiding/revisjon av selve manuset og godkjenning av innsendte manusversjon. Torvald Espeland er stipendiat, spesialist i indremedisin og lege i spesialisering i hjertesykdommer. Forfatter har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter.

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Mitral annular plane systolic excursion is an easy tool for fibrosis detection by late gadolinium enhancement cardiovascular magnetic resonance imaging in patients with hypertrophic cardiomyopathy

Cited by 13 publications

References 36 publications

High sensitivity troponin T and I reflect mitral annular plane systolic excursion being assessed by cardiac magnetic resonance imaging

High sensitivity troponin T and I reflect mitral annular plane systolic excursion being assessed by cardiac magnetic resonance imaging

Galectin-3 Reflects Mitral Annular Plane Systolic Excursion Being Assessed by Cardiovascular Magnetic Resonance Imaging

Myokardfibrose

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