Mitral valve and papillary muscle abnormalities in hypertrophic obstructive cardiomyopathy

Teo, Eliza; Teoh, Jonathan G.; Hung, Judy

doi:10.1097/hco.0000000000000200

Cited by 43 publications

(32 citation statements)

References 25 publications

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“…107 Tranthoracic echocardiography 2D echocardiography provides useful data concerning the distribution and extent of LVH, especially during diastole in parasternal short-axis plane. Alternative imaging windows are also used to confirm measurements.…”

Section: The Role Of Echocardiography In Hcm Diagnosismentioning

confidence: 99%

“…107 The MR jet flow is easier to differentiate from LVOT jet flow when the Doppler beam is progressively oriented from the LVOT flow towards the MR flow. Furthermore, the two flows can be displayed separately when sweeping constantly from one flow to another.…”

mentioning

confidence: 99%

“…118 ( Figure 5) Provocation tests using amyl nitrite, exercise or the Valsalva maneuver may be applied either for an enhanced diagnosis or for evaluating the response to pharmacologic agents. 97,107 As leaflets are pulled into the LVOT during SAM of the MV, leaflet apposition becomes asymmetric and incomplete, resulting in a MR jet which is directed posteriorly. 107,111 When the LVOT jet is present concomitantly with a MR jet, distinguishing signals from the two is challenging and the efficacy of a single flow assessment may be altered 119 In terms of timing, LVOTO typically has a late systolic peak and a "dagger shaped" continuous-wave profile.…”

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confidence: 99%

“…100 Papillary muscle insertion abnormalities are easier to identify when using off-axis views with 2D echocardiography. 107 Transesopahgeal echocardiography TEE studies are mostly used for thorough periprocedural evaluation for planning purposes, although they are also useful when transthoracic views are not accurate enough.…”

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confidence: 99%

“…Continuous-wave Doppler evaluates velocities from the LV apex to the MV plane in an attempt to determine the peak flow of MR. 107 A comprehensive examination is done in both parasternal and apical views from the medial to the lateral margins of the MV. 100 Papillary muscle insertion abnormalities are easier to identify when using off-axis views with 2D echocardiography.…”

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confidence: 99%

See 4 more Smart Citations

The mechanisms, diagnosis and management of mitral regurgitation in mitral valve prolapse and hypertrophic cardiomyopathy

Popa

Irimia

Papagheorghe

et al. 2016

Discoveries (Craiova)

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Section: The Role Of Echocardiography In Hcm Diagnosismentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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The mechanisms, diagnosis and management of mitral regurgitation in mitral valve prolapse and hypertrophic cardiomyopathy

Popa

Irimia

Papagheorghe

et al. 2016

Discoveries (Craiova)

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Genotype‐cardiac phenotype correlations in a large single‐center cohort of patients affected by RASopathies: Clinical implications and literature review

Leoni

Blandino

Delogu

et al. 2021

American J of Med Genetics Pt A

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Congenital heart disease (CHD) and hypertrophic cardiomyopathy (HCM) are common features in patients affected by RASopathies. The aim of this study was to assess genotype‐ phenotype correlations, focusing on the cardiac features and outcomes of interventions for cardiac conditions, in a single‐center cohort of 116 patients with molecularly confirmed diagnosis of RASopathy, and compare these findings with previously published data. All enrolled patients underwent a comprehensive echocardiographic examination. Relevant information was also retrospectively collected through the analysis of clinical records. As expected, significant associations were found between PTPN11 mutations and pulmonary stenosis (both valvular and supravalvular) and pulmonary valve dysplasia, and between SOS1 mutations and valvular defects. Similarly, HRAS mutations were significantly associated with HCM. Potential associations between less prevalent mutations and cardiac defects were also observed, including RIT1 mutations and HCM, SOS2 mutations and septal defects, and SHOC2 mutations and septal and valve abnormalities. Patients with PTPN11 mutations were the most likely to require both a primary treatment (transcatheter or surgical) and surgical reintervention. Other cardiac anomalies less reported until recently in this population, such as isolated functional and structural mitral valve diseases, as well as a sigmoid‐shaped interventricular septum in the absence of HCM, were also reported. In conclusion, our study confirms previous data but also provides new insights on cardiac involvement in RASopathies. Further research concerning genotype/phenotype associations in RASopathies could lead to a more rational approach to surgery and the consideration of drug therapy in patients at higher risk due to age, severity, anatomy, and comorbidities.

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Is There a Role for Alcohol Septal Ablation in Young Patients with Medically Refractory Hypertrophic Obstructive Cardiomyopathy?

Sivakumar

Jain

2023

Pediatr Cardiol

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Mitral valve and papillary muscle abnormalities in hypertrophic obstructive cardiomyopathy

Abstract: Mitral valve abnormalities are common in hypertrophic obstructive cardiomyopathy and play an important role in the pathophysiology of dynamic left ventricular outflow tract obstruction.

Cited by 43 publications

References 25 publications

The mechanisms, diagnosis and management of mitral regurgitation in mitral valve prolapse and hypertrophic cardiomyopathy

The mechanisms, diagnosis and management of mitral regurgitation in mitral valve prolapse and hypertrophic cardiomyopathy

Genotype‐cardiac phenotype correlations in a large single‐center cohort of patients affected by RASopathies: Clinical implications and literature review

Is There a Role for Alcohol Septal Ablation in Young Patients with Medically Refractory Hypertrophic Obstructive Cardiomyopathy?

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