Mitral valve prolapse imaging: the role of tissue characterization

Pradella, Silvia; Grazzini, Giulia; Miele, Vittorio

doi:10.21037/qims-2020-25

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…Advantages over echocardiography include the ability for tissue characterization, unlimited imaging planes, no dependency on an acoustic window, and accurate determination of LV volumes and function. 60,61 Also, CMRI may better define MAD of minor degree (MAD < 4 mm) 62 (Figure 3).…”

Section: Cardiac Magnetic Resonance Imagingmentioning

confidence: 99%

“…88 Cardiac Magnetic Resonance Imaging CMRI can have a pivotal role in identifying fibrotic myocardial tissue replacement by T1 mapping (T1-map) and abnormal myocardial strain by CMRI feature tracking. 60,89,90 Following gadolinium administration, delayed enhancement and increased extracellular space may represent fibrosis or proteoglycan deposition, both of which are strong predictors of VA events, SCD or heart failure. Therefore, such findings may be useful for clinical decision processes and prognostication.…”

Section: Speckle-tracking Echocardiography and Tissue-doppler Imagingmentioning

confidence: 99%

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Mitral Valve Prolapse—The Role of Cardiac Imaging Modalities

2022

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Section: Cardiac Magnetic Resonance Imagingmentioning

confidence: 99%

Section: Speckle-tracking Echocardiography and Tissue-doppler Imagingmentioning

confidence: 99%

Mitral Valve Prolapse—The Role of Cardiac Imaging Modalities

2022

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“…Mapping is an MRI technique used to calculate the T1 or T2 time of a certain tissue and display them voxel by voxel on a parametric map, helping in myocardial tissue characterization [ 54 ].…”

Section: Cardiac Magnetic Resonancementioning

confidence: 99%

Practical Guide to Interpreting Cardiac Magnetic Resonance in Patients with Cardiac Masses

Grazzini

Pradella

Rossi

et al. 2023

JCDD

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It is common for a cardiac mass to be discovered accidentally during an echocardiographic examination. Following the relief of a cardiac mass, being able to evaluate and characterize it using non-invasive imaging methods is critical. Echocardiography, computed tomography (CT), cardiac magnetic resonance imaging (CMR), and positron emission tomography (PET) are the main imaging modalities used to evaluate cardiac masses. Although multimodal imaging often allows for a better assessment, CMR is the best technique for the non-invasive characterization of tissues, as the different MR sequences help in the diagnosis of cardiac masses. This article provides detailed descriptions of each CMR sequence employed in the evaluation of cardiac masses, underlining the potential information it can provide. The description in the individual sequences provides useful guidance to the radiologist in performing the examination.

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“…The T2 relaxation time is a CMR biomarker more specific to the free water content in tissue compared to that in T1 [23]. In fact, the T1 relaxation time is influenced by both extracellular and intracellular compartments, so both free water and the water bound to large molecules such as amyloid may increase the T1 values [24,25].…”

Section: Introductionmentioning

confidence: 99%

The Role of T2 Mapping in Cardiac Amyloidosis

Grazzini,

Pradella,

Bani

et al. 2024

Diagnostics

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Cardiac amyloidosis (CA) is an infiltrative cardiomyopathy divided into two types: light-chain (LA) and transthyretin (ATTR) CA. Cardiac magnetic resonance (CMR) has emerged as an important diagnostic tool in CA. While late gadolinium enhancement (LGE), T1 mapping and extracellular volume (ECV) have a consolidate role in the assessment of CA, T2 mapping has been less often evaluated. We aimed to test the value of T2 mapping in the evaluation of CA. This study recruited 70 patients with CA (51 ATTR, 19 AL). All the subjects underwent 1.5 T CMR with T1 and T2 mapping and cine and LGE imaging. Their QALE scores were evaluated. The myocardial T2 values were significantly (p < 0.001) increased in both types of CA compared to the controls. In the AL-CA group, increased T2 values were associated with a higher QALE score. The myocardial native T1 values and ECV were significantly (p < 0.001) higher in the CA patients than in the healthy subjects. Left ventricular (LV) mass, QALE score and ECV were higher in ATTR amyloidosis compared with AL amyloidosis, while the LV ejection fraction was lower (p < 0.001). These results support the concept of the presence of myocardial edema in CA. Therefore, a CMR evaluation including not only myocardial T1 imaging but also myocardial T2 imaging allows for more comprehensive tissue characterization in CA.

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Mitral valve prolapse imaging: the role of tissue characterization

Cited by 5 publications

References 24 publications

Mitral Valve Prolapse—The Role of Cardiac Imaging Modalities

Mitral Valve Prolapse—The Role of Cardiac Imaging Modalities

Practical Guide to Interpreting Cardiac Magnetic Resonance in Patients with Cardiac Masses

The Role of T2 Mapping in Cardiac Amyloidosis

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