Mitral Valve Replacement in Pediatrics Using an Extracellular Matrix Cylinder Valve: A Case Series

Kiper, Carmen; Clifford, L.; Baker, Peter B.; McConnell, Patrick I.

doi:10.1007/s00246-020-02382-3

Cited by 10 publications

(5 citation statements)

References 26 publications

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“…Other case studies also found favorable short-term outcomes in tricuspid and mitral valve repairs with CorMatrix, reporting successful repairs, excellent valve function, and good hemodynamic results at 3 months and 2 months, respectively. 2,6,10 Luke and associates, however, reported delayed post-operative infection and perforation of the MV leaflet after histological examination of explanted CorMatrix in 2 adults. 4 They reported 10 and 12 month follow-up outcomes, which contrasts with the aforementioned case studies that reported more short-term results.…”

Section: Discussionmentioning

confidence: 99%

Pediatric Aortic Valve Repair: Any development in the material for cusp extension valvuloplasty?

Siddiqi

Lee³

et al. 2021

Preprint

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Background: Aortic cusp extension is a technique for aortic valve (AV) repairs in pediatric patients. The choice of the material used in this procedure may influence the time before reoperation is required. We aimed to assess post-operative and long-term outcomes of patients receiving either pericardial or synthetic repairs. Methods: We conducted a single center, retrospective study of pediatric patients undergoing aortic cusp extension valvuloplasty (N=38) with either autologous pericardium (n=30) or Cormatrix (n=8) between April 2009 and July 2016. Short and long-term postoperative outcomes were compared between the two groups. Freedom from reoperation was compared using Kaplan Meier analysis. Degree of aortic stenosis (AS) and aortic regurgitation (AR) were recorded at baseline, post-operatively, and at outpatient follow-up. Results: At five years after repair, freedom from reoperation was significantly lower in the CorMatrix group (12.5%) compared to the pericardium group (62.5%) (P = 0.01). For the entire cohort, there was a statistically significant decrease in the peak trans-valvar gradient between pre- and post-operative assessments with no significant change at outpatient follow-up. In the pericardium group, 28 (93%) had moderate to severe AR at baseline which improved to 11 (37%) post-operatively and increased to 21 (70%) at time of follow-up. In the biomaterial group, 8 (100%) had moderate to severe AR which improved to 3 (38%) post-operatively and increased to 7 (88%) at time of follow-up. Conclusion: In terms of durability, the traditional autologous pericardium may outperform the new CorMatrix for AV repairs using the cusp extension method.

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Section: Discussionmentioning

confidence: 99%

Pediatric Aortic Valve Repair: Any development in the material for cusp extension valvuloplasty?

Siddiqi

Lee³

et al. 2021

Preprint

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“…In general, low flow blood systems or the possibility of systemic embolization require more aggressive anticoagulation. As even newer valves continue to be made available for replacement purposes in the pediatric population, future studies will be required to determine the optimal anticoagulation regimen [102][103][104][105].…”

Section: Artificial Valve Thrombosismentioning

confidence: 99%

Thrombosis Prevention and Anticoagulation Management in the Pediatric Patient with Congenital Heart Disease

et al. 2021

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Thrombosis is one of the most frequent complications affecting children with congenital heart disease (CHD). Palliative and reparative cardiac surgeries are some of the main players contributing to the thrombosis risk in this patient population. Additional risk factors related to the CHD itself (e.g., cardiac dysfunction, arrhythmias, and polycythemia in cyanotic cardiac disorders) can contribute to thrombogenicity alone or combined with other factors. Thrombotic complications have been recognized as a significant cause of morbidity and mortality in this patient population. Here, we provide an overview of the pathophysiology and risk factors for thrombosis as well as the indications for and use of different anticoagulation, antiplatelet, and thrombolytic agents. In addition, we describe some of most common thrombotic complications and their management in the pediatric CHD population.

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“…4,5 Recently CorMatrix extracellular matrix (ECM) (CorMatrix Cardiovascular, Alpharetta, GA, USA), which is manufactured from porcine intestinal submucosa, has emerged as a leading choice for several cardiovascular and peripheral vascular repair procedures, especially in pediatric populations. [6][7][8][9][10] CorMatrix ECM is a biological scaffold, 90% of CorMatrix ECM is collagen (predominantly type I), other components include proteoglycan, fibronectin, laminin, thrombospondins, osteopontin, tenascins, and growth factors. 11 In theory, the three-dimensional structure of CorMatrix supports the ingrowth of host cells; it is sufficiently bioactive to initiate and maintain molecular control over proliferation and differentiation of the host cells and is absorbable.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pathological Changes of Adult Mitral Valves after Failed CorMatrix ECM Repair

2021

Journal of Clinical and Translational Pathology

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Mitral Valve Replacement in Pediatrics Using an Extracellular Matrix Cylinder Valve: A Case Series

Cited by 10 publications

References 26 publications

Pediatric Aortic Valve Repair: Any development in the material for cusp extension valvuloplasty?

Pediatric Aortic Valve Repair: Any development in the material for cusp extension valvuloplasty?

Thrombosis Prevention and Anticoagulation Management in the Pediatric Patient with Congenital Heart Disease

Pathological Changes of Adult Mitral Valves after Failed CorMatrix ECM Repair

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