2018
DOI: 10.2147/imcrj.s151693
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Mixed connective tissue disease complicated by heart failure in Ile-Ife, Nigeria: management challenges in a resource-limited economy

Abstract: BackgroundMixed connective tissue disease (MCTD; also known as Sharp’s syndrome) is a rare autoimmune inflammatory disorder characterized by high titer of U1 ribonucleoprotein (U1RNP) antibody and clinical and serological overlap of systemic lupus erythematosus, systemic sclerosis, and polymyositis. The diagnosis is based on clinical and serological factors in criteria such as Alarcon-Segovia, Khan, Kusakawa, and Sharps. Cardiac disease can be a complication of connective tissue disease (CTD). There are few re… Show more

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Cited by 2 publications
(4 citation statements)
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“…We, thereby, ventured to study the clinical profile and treatment practices of jMCTD patients from several centers in the most populous part of the world. The mean age at onset for the patients in our cohort was 10.4 years, which aligns with prior literature that found the average age at onset for jMCTD to be between 9.5 and 12 years, with a higher occurrence among females 10 . Although our youngest patient was 4 years old, there are reports of MCTD occurring in children as young as 2.5 years of age 16 …”
Section: Discussionsupporting
confidence: 88%
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“…We, thereby, ventured to study the clinical profile and treatment practices of jMCTD patients from several centers in the most populous part of the world. The mean age at onset for the patients in our cohort was 10.4 years, which aligns with prior literature that found the average age at onset for jMCTD to be between 9.5 and 12 years, with a higher occurrence among females 10 . Although our youngest patient was 4 years old, there are reports of MCTD occurring in children as young as 2.5 years of age 16 …”
Section: Discussionsupporting
confidence: 88%
“…The mean age at onset for the patients in our cohort was 10.4 years, which aligns with prior literature that found the average age at onset for jMCTD to be between 9.5 and 12 years, with a higher occurrence among females. 10 Although our youngest patient was 4 years old, there are reports of MCTD occurring in children as young as 2.5 years of age. 16 Diagnosis was primarily based on Kasukawa's criteria in our cohort, followed by Alacron-Segovia's criteria.…”
Section: Discussionmentioning
confidence: 79%
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