Mixed Matrix Membranes: A New Asset for Blood Purification Therapies

Tijink, Msl; Kooman, Jeroen P.; Wester, Maarten; Sun, Jiatong; Saiful, Saiful; Joles, JA Jaap; Borneman, Zandrie; Weßling, Matthias; Stamatialis, Dimitrios

doi:10.1159/000356226

Cited by 35 publications

(12 citation statements)

References 21 publications

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“…The first prototype is currently undergoing preclinical testing and is expected to be tested in humans soon, with the aim of demonstrating proof-of-concept for the first portable haemodialysis machine for daily use, requiring only a limited volume of dialysate. In addition to the development of miniaturization technologies, the partnership is also investigating the use of polymer membranes that permit combined filtration and absorption to achieve more effective haemodialysis 138 .…”

Section: Fostering Innovationmentioning

confidence: 99%

The current and future landscape of dialysis

Vanholder²,

et al. 2020

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The development of dialysis by early pioneers such as Willem Kolff and Belding Scribner set in motion several dramatic changes in the epidemiology, economics and ethical frameworks for the treatment of kidney failure. However, despite a rapid expansion in the provision of dialysis — particularly haemodialysis and most notably in high-income countries (HICs) — the rate of true patient-centred innovation has slowed. Current trends are particularly concerning from a global perspective: current costs are not sustainable, even for HICs, and globally, most people who develop kidney failure forego treatment, resulting in millions of deaths every year. Thus, there is an urgent need to develop new approaches and dialysis modalities that are cost-effective, accessible and offer improved patient outcomes. Nephrology researchers are increasingly engaging with patients to determine their priorities for meaningful outcomes that should be used to measure progress. The overarching message from this engagement is that while patients value longevity, reducing symptom burden and achieving maximal functional and social rehabilitation are prioritized more highly. In response, patients, payors, regulators and health-care systems are increasingly demanding improved value, which can only come about through true patient-centred innovation that supports high-quality, high-value care. Substantial efforts are now underway to support requisite transformative changes. These efforts need to be catalysed, promoted and fostered through international collaboration and harmonization.

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Section: Fostering Innovationmentioning

confidence: 99%

The current and future landscape of dialysis

Vanholder²,

et al. 2020

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“…Others have proposed a mixed-matrix membrane, which combined adsorbent charcoal membranes separated from blood by a particle-free polymeric layer. Although discussed in terms of uremic solute removal, developers note that they can remove protein-bound compounds, suggesting a wider possible role in treating poisoning [35,36].…”

Section: Low and High Flux Membranesmentioning

confidence: 99%

Developments in extracorporeal therapy for the poisoned patient

Patel

Bayliss

2015

Advanced Drug Delivery Reviews

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“…Since the issue of the transport properties optimization of nanocomposite polymer membranes remains relevant to this day, there have been attempts to make some generalizations known; review papers [1,5,13,[24][25][26][27][28][29]. These studies raises general questions [1,30], but in most cases the analytical generalizations were made for solving specific problems of a separation [31][32][33][34][35][36] or other tasks including fuel cells or catalytic membrane reactors applications [37][38][39][40][41][42][43]. In general, it is necessary to highlight review articles in which information is collected on the introduction of a certain type of nanoparticles in polymer films of different morphologies, for example membranes-containing 0D to 2D nano-fillers [37,44,45].…”

Section: Introductionmentioning

confidence: 99%

Polymer Nanocomposite Membranes

et al. 2018

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Based on the results of research works reflected in the scientific literature, the main examples, methods and approaches to the development of polymer inorganic nanocomposite materials for target membranes are considered. The focus is on membranes for critical technologies with improved mechanical, thermal properties that have the necessary capabilities to solve the problems of a selective pervaporation. For the purpose of directional changes in the parameters of membranes, effects on their properties of the type, amount and conditions of nanoparticle incorporation into the polymer matrix were analyzed. An influence of nanoparticles on the structural and morphological characteristics of the nanocomposite film is considered, as well as possibilities of forming transport channels for separated liquids are analyzed. Particular attention is paid to a correlation of nanocomposite structure-transport properties of membranes, whose separation characteristics are usually considered within the framework of the diffusion-sorption mechanism.

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Mixed Matrix Membranes: A New Asset for Blood Purification Therapies

Cited by 35 publications

References 21 publications

The current and future landscape of dialysis

The current and future landscape of dialysis

Developments in extracorporeal therapy for the poisoned patient

Polymer Nanocomposite Membranes

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