Mixed Phenotype Acute Leukemia Presenting as Leukemia Cutis

Narayanan, Geetha; Sugeeth, MT; Soman, Lali V

doi:10.1155/2016/1298375

Cited by 4 publications

(7 citation statements)

References 12 publications

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“…LC is more common in AML-than CML patients. Its prevalence in these patients is around 10 -15% 12 . Chromosomal abnormalities (especially trisomy chromosome 8) are also associated with the progression of LC in patients with AML 2 .…”

Section: Discussionmentioning

confidence: 99%

Salvage chemotherapy for the treatment of Leukemia cutis in a patient with acute monocytic leukemia

Payandeh

Karami

et al. 2019

Biomed. Res. Ther.

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Leukemia cutis (LC) is a rare disorder that is distinguished by the infiltration of leukemic cells into the skin. This can be a manifestation of relapse of the previously treated leukemia. We report a case of a 70-year-old woman with acute monocytic leukemia (AMOL), whose disease relapsed and developed into LC after a successful induction therapy. Salvage chemotherapy has been applied successfully to prevent the development of LC in the patient's skin.

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Section: Discussionmentioning

confidence: 99%

Salvage chemotherapy for the treatment of Leukemia cutis in a patient with acute monocytic leukemia

Payandeh

Karami

et al. 2019

Biomed. Res. Ther.

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“…The LC is an extramedullary infiltration of leukemia leucocytes or their precursors into the epidermis, dermis, subcutis, or blood vessels appeared as variable clinically skin lesions. [ 3 , 14 , 15 ] Cutaneous infiltration of the skin occurs in 1% to 3% of patients with ALL. [ 16 ] It could precede, be concomitant with, or follow the diagnosis of leukemia, or a relapse of it.…”

Section: Discussionmentioning

confidence: 99%

“…[ 17 ] The exact mechanism behind the specific migration of leukemic cells to the skin has not yet been clarified. [ 14 ]…”

Section: Discussionmentioning

confidence: 99%

“…Control of the cutaneous involvement was essential, considering that LC has been suggested as a marker for aggressive disease and was frequently accompanied by infiltration into other organs such as the liver, spleen, and lymph nodes, which was associated with poor prognosis. [ 14 , 15 , 17 , 18 ] Curative treatment should be directed at eradicating the underlying disease using chemotherapy or HSCT, possibly in the first remission. However, chemotherapy that is adequate to induce and maintain marrow remission does not always control cutaneous involvement.…”

Section: Discussionmentioning

confidence: 99%

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Chimeric antigen receptor-modified T-cell therapy for bone marrow and skin relapse Philadelphia chromosome-like acute lymphoblastic leukemia

Yang

Liu²,

Wang³

et al. 2020

Medicine

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Rationale: Chimeric antigen receptor-modified T-cell (CART) therapy has revolutionized the treatment of patients with relapsed or refractory B-cell acute lymphoblastic leukemia (ALL). However, the capacity of CART therapy has not yet been fully elucidated. Patient concerns: An 18-year-old Chinese male patient presented with multiple firm masses on the skin all over his body following regular chemotherapy. Diagnoses: Bone marrow smear and skin biopsy confirmed that it was a bone marrow and skin relapse from the initial B-cell ALL. Interventions: CD19 CART-cell therapy was performed to manage the bone marrow and skin of the relapsed B-cell ALL. Outcomes: During CART-cell therapy, cytokine release syndrome and central nervous encephalopathy occurred. Eventually, the lesions disappeared, and the bone marrow and skin tested minimal residual disease (MRD) negative. The patient achieved complete remission (CR). Fourteen days after testing MRD negative, he received allogeneic hematopoietic stem-cell transplantation and has remained disease free to date. Lessons: The CR of this patient with leukemia cutis demonstrated that CART exhibited efficacy in this case. While further research is still required, this treatment could potentially be used as a therapy for skin leukemia, lymphoma, and other primary skin cancers.

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“…Mixed phenotype acute leukemia (MPAL) is a rare neoplasm which accounts for 2–5% of all leukemia [3, 4] and extramedullary presentation of them is extremely uncommon. Here we introduce a case of T/Myeloid mixed phenotype acute leukemia presented in lymph node which has t(1;5)(q23;q33).…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Extramedullary T/Myeloid Mixed Phenotype Acute Leukemia with t(1;5)(q23;q33)

Monabati

Safaei

Nouri

et al. 2016

Case Reports in Pathology

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Mixed phenotype acute leukemia (MPAL) is a rare neoplasm which accounts for 2–5% of all leukemias and it is classified under heading of acute leukemia of ambiguous lineage in 2008 WHO classification. This patient was a 61-year-old man who presented with malaise and weakness. In physical examination there was cervical and axillary lymphadenopathy. Paraclinical evaluation revealed anemia (Hb = 10.3 g/dL, MCV = 108 fl). Histologic sections of the axillary lymph node revealed leukemic involvement with two discrete populations of cells in immunohistochemistry. One population was immunoreactive for MPO and the other showed immunostaining for CD3, CD99, and tdt. Differential count of bone marrow cells in marrow aspirate had 6% blast. Karyotype study on bone marrow culture depicted an interesting finding which was t(1;5)(q23;q33). An extensive search on literature was done for the same genetic change. A similar translocation has been mentioned in literature for other hematologic malignancies but not for same neoplasm; anyhow this translocation was an imbalanced one and led to der(5)t(1;5)(q12-25;q13-q35).

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Mixed Phenotype Acute Leukemia Presenting as Leukemia Cutis

Cited by 4 publications

References 12 publications

Salvage chemotherapy for the treatment of Leukemia cutis in a patient with acute monocytic leukemia

Salvage chemotherapy for the treatment of Leukemia cutis in a patient with acute monocytic leukemia

Chimeric antigen receptor-modified T-cell therapy for bone marrow and skin relapse Philadelphia chromosome-like acute lymphoblastic leukemia

A Rare Case of Extramedullary T/Myeloid Mixed Phenotype Acute Leukemia with t(1;5)(q23;q33)

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