Mixing Intensity Studies by Simd using Dissimilar Stirrers. Case Study: Production of Fusicoccin by the Fungus Fusicoccum Amygdali Del.

Priede, Martins; Vanags, Juris; Viesturs, U.

doi:10.1080/13102818.1995.10818868

Cited by 2 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In conditions where the intensity of local turbulence is high but insufficient for the mechanical disruption of the cultivated cells, changes in the cell morphology were often observed [2,56,62,[66][67][68][69][70][71][72][73][74][75][76]. Simultaneously with morphological adjustment, the physiological character, namely, the productivity of metabolite synthesis [66,67,69,72,73,76], biological activity [70,74,77] and enzyme activity [71] also changed.…”

Section: Figmentioning

confidence: 99%

“…Simultaneously with morphological adjustment, the physiological character, namely, the productivity of metabolite synthesis [66,67,69,72,73,76], biological activity [70,74,77] and enzyme activity [71] also changed. Hence, these morphological changes may be regarded to be not a simple result of the mechanical deformation of cells, but a reaction to the changes in cultivation conditions.…”

Section: Figmentioning

confidence: 99%

See 1 more Smart Citation

Excess turbulence as a cause of turbohypobiosis in cultivation of microorganisms

2007

View full text Add to dashboard Cite

Abstract:The present review describes the influence of different types of mixing systems under excess turbulence conditions on microorganisms. Turbohypobiosis phenomena were described by applying a method for measurement of the kinetic energy of flow fluctuations based on the piezoeffect. It can be assumed that the shear stress effect (the state of turbohypobiosis) plays a role mainly when alternative mechanisms in cells cannot ensure a normal physiological state under stress conditions. Practically any system (inner construction of a bioreactor, culture and cultivation conditions, including mixing) requires its own optimisation to achieve the final goal, namely, the maximum product and/or biomass yields from substrate (Y P/S or/and Y X/S ), respectively. Data on the biotechnological performance of cultivation as well as power input, kinetic energy (e) of flow fluctuations, air consumption rate, rotational speed, tip speed, etc. do not correlate directly if the mixing systems (impellers-baffles) are dissimilar. Even the widely used specific power consumption cannot be relied upon for scaling up the cultivation performance using dissimilar mixing systems. A biochemical explanation for substrate and product transport via cell walls, carbon pathways, energy generation and utilisation, etc. furnishes insight into cellular interactions with turbulence of different origin for different types of microorganisms (single cells, mycelia forming cells, etc.

show abstract