Mizuo Phenomenon in X-linked Retinoschisis

Jong, P.T.V.M. de

doi:10.1001/archopht.1991.01080080064029

Cited by 62 publications

(10 citation statements)

References 24 publications

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“…The ophthalmic findings in our patient closely resemble those of the four cases of retinoschisis described by Dejong et al [8]; however, the following differences remained:…”

Section: Discussionsupporting

confidence: 87%

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A Case of a Combination of Oguchi’s Disease and Congenital Retinoschisis

Ohguro¹,

Suzuki²,

Nakagawa³

1998

Ophthalmologica

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We report here a rare case of a combination of Oguchi’s disease and congenital retinoschisis. A 36-year-old male patient presented with a decrease in vision in both eyes and night blindness. Indirect ophthalmoscopy revealed bilateral macular stellate striations and golden-gray discoloration of the retina outside the vascular arcades. This discoloration turned to a normal retina after complete adaptation to darkness (Mizuo-Nakamura phenomenon).

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“…The ophthalmic findings in our patient closely resemble those of the four cases of retinoschisis described by Dejong et al [8]; however, the following differences remained:…”

Section: Discussionsupporting

confidence: 87%

“…The Mizuo-Nakamura phenomenon is known to be a specific sign of Oguchi’s disease, an unusual form of congenital night blindness [4, 5], but has also been described in X-linked recessive cone dystrophy [6], Stargardt’s disease [7] and X-linked retinoschisis [8]. …”

Section: Discussionmentioning

confidence: 99%

A Case of a Combination of Oguchi’s Disease and Congenital Retinoschisis

Ohguro¹,

Suzuki²,

Nakagawa³

1998

Ophthalmologica

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“…This was first reported in four unrelated males by Jong et al . [ 13 ] Tapetal reflex was found to be seen in the eight eyes (four patients) in our study. Etiology of tapetal reflex has been well-described by the mechanism of increased concentrations of potassium or potassium chloride giving rise to yellowish fundus reflex in eyes with retinoschisis.…”

Section: Discussionsupporting

confidence: 50%

Phenotypic characterization of X-linked retinoschisis: Clinical, electroretinography, and optical coherence tomography variables

Neriyanuri

Raman

2016

Indian J Ophthalmol

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Aims:To study the phenotypic characteristics of X-linked retinoschisis (XLRS) and report the clinical, electroretinogram (ERG), and optical coherence tomography (OCT) variables in Indian eyes.Design:A retrospective study.Materials and Methods:Medical records of 21 patients with retinoschisis who were genetically confirmed to have RS1 mutation were reviewed. The phenotype characterization included the age of onset, best-corrected visual acuity, refractive error, fundus findings, OCT, and ERG.Statistical Analysis Used:Data from both the eyes were used for analysis. A P < 0.05 was set as statistical significance. Data were not normally distributed (P < 0.05, Shapiro wilk); hence, nonparametric tests were used for statistical analysis.Results:All were males whose mean age of presentation was 9 years. Visual acuity was moderately impaired (median 0.6 logMAR, interquartile range: 0.47, 1) in these eyes with a hyperopic refractive error of median +1.75 Ds (interquartile range: +0.50 Ds, +4.25 Ds). About 54.7% of the eyes had both foveal and peripheral schisis, isolated foveal schisis was seen in 28.5% of the eyes, and schisis with retinal detachment was seen in 16.6% of the eyes. The inner nuclear layer was found to be commonly involved in the schisis, followed by outer nuclear and plexiform layers as evident on OCT. On ERG, a- and b-wave amplitudes were significantly reduced in eyes with foveal and peripheral schisis when compared to the eyes with only foveal schisis (P < 0.05).Conclusions:XLRS has phenotypic heterogeneity as evident on OCT, ERG, and clinical findings.

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“…C: Current differences between (A) and (B), i.e., Na+-dependent currents. D: Mean Na' current of retinoschisis (DeJong et al, 1991). Likewise, strong [K+l, rises are likely to occur in various retinal lesions, as, e.g., in retinal ablation when most neurons die.…”

Section: How Can Glial Cell Na' Channels Be Activated?mentioning

confidence: 99%

Na⁺ channels of Müller (glial) cells isolated from retinae of various mammalian species including man

Chao

Skachkov

Eberhardt

et al. 1994

Glia

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Within the last few years, the expression of voltage-dependent, TTX-sensitive Na+ channels has been demonstrated in several types of neuroglial cells such as astrocytes and Schwann cells. Recently, we reported the occurrence of such Na+ currents in retinal Müller (glial) cells from dog and cat. This paper deals with the description of the properties of Na+ currents in Müller cells isolated from retinae of several mammalian species, as well as from human retinae. These Na+ currents were eliminated by TTX (1 microM), and by exposure to sodium-free extracellular solution; typically, they were demonstrable only after blocking most of the K+ conductance by Ba2+ (1 mM). Voltage-dependent activation and inactivation characteristics and time constants of the Na+ currents were similar to those of currents carried by neuronal Na+ channels. The estimated number of sodium channels per cell was low (about 1,500 channels per 7,500 microns 2), and the K+ conductance exceeded the peak Na+ conductance by an average factor of 5. Thus, the cells were incapable of generating action-potential-like responses under current clamp. Modelling estimations show that triggering of glial Na+ currents under physiological conditions, if any, can at best occur by emhaptic transmission at perinodal sites of optic axons. It is speculated that glial Na+ channels might be involved in neuroglial signalling events.

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Mizuo Phenomenon in X-linked Retinoschisis

Cited by 62 publications

References 24 publications

A Case of a Combination of Oguchi’s Disease and Congenital Retinoschisis

A Case of a Combination of Oguchi’s Disease and Congenital Retinoschisis

Phenotypic characterization of X-linked retinoschisis: Clinical, electroretinography, and optical coherence tomography variables

Na⁺ channels of Müller (glial) cells isolated from retinae of various mammalian species including man

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Mizuo Phenomenon in X-linked Retinoschisis

Cited by 62 publications

References 24 publications

A Case of a Combination of Oguchi’s Disease and Congenital Retinoschisis

A Case of a Combination of Oguchi’s Disease and Congenital Retinoschisis

Phenotypic characterization of X-linked retinoschisis: Clinical, electroretinography, and optical coherence tomography variables

Na+ channels of Müller (glial) cells isolated from retinae of various mammalian species including man

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Na⁺ channels of Müller (glial) cells isolated from retinae of various mammalian species including man