2020
DOI: 10.1080/00207454.2019.1667785
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MKP1 in the medial prefrontal cortex modulates chronic neuropathic pain via regulation of p38 and JNK1/2

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Cited by 5 publications
(5 citation statements)
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“…The PFC, along with the anterior cingulate, the somatosensory I and II areas, and the insular cortices are among the most important areas of the brain activated during pain processing [ 8 , 10 ]. In addition, studies showed an association between the mPFC and neuropathic pain [ 7 , 49 ]. Based on the results of this study, the NO system in the mPFC can play a role in reducing neuropathic pain.…”
Section: Discussionmentioning
confidence: 99%
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“…The PFC, along with the anterior cingulate, the somatosensory I and II areas, and the insular cortices are among the most important areas of the brain activated during pain processing [ 8 , 10 ]. In addition, studies showed an association between the mPFC and neuropathic pain [ 7 , 49 ]. Based on the results of this study, the NO system in the mPFC can play a role in reducing neuropathic pain.…”
Section: Discussionmentioning
confidence: 99%
“…The medial part of the PFC (mPFC) participates in many brain-related tasks such as memory and learning, planning and decision-making, emotional processing, and anxiety [ 5 , 6 ]. In addition, the role of PFC and notably the mPFC in modulation of acute and chronic pain was reported [ 7 , 8 ]. The mPFC receives ascending, nociceptive inputs and also sends projections to control the descending inhibitory pain pathways [ 9 ].…”
Section: Introductionmentioning
confidence: 99%
“…The key step of p38MAPK phosphorylation in the central nervous system [ 7 , 8 ] and peripheral nervous system [ 9 11 ] in mediating neuroinflammation and resulting in neuropathic pain has been approached recently in several studies. The importance of the involvement of p38MAPK phosphorylation in the development and maintenance of neuropathic pain boosts us to explore the association of p38MAPK phosphorylation and P2X7R activation in mediating BTZ-induced neuropathic pain.…”
Section: Discussionmentioning
confidence: 99%
“…It leads to the induction and expansion of neuropathic pain status. p38MAPK phosphorylation in the central nervous system [ 7 , 8 ] and peripheral nervous system [ 9 11 ] is closely correlated with neuroinflammation and neuropathic pain.…”
Section: Introductionmentioning
confidence: 99%
“…The medial prefrontal cortex (mPFC) is a central mediator in the pain pathway, which is crucial as an integrator of ascending sensory information, cognitive and emotional responses, and descending inhibitory control ( Ong et al, 2019 ; Kummer et al, 2020 ). Changes in gene expression in the PFC play a role in acute and chronic pain development and maintenance ( Yan et al, 2019 ; Cai et al, 2020 ; Qian et al, 2020 ; Shiers and Price, 2020 ; Topham et al, 2020 ). During chronic pain states, it has been reported that mPFC undergoes structural and functional plasticity ( Obermann et al, 2013 ; Liu et al, 2018 ; Sang et al, 2018 ; Huang et al, 2020 ).…”
Section: Introductionmentioning
confidence: 99%