Mn-Si-based nanoparticles-enhanced inhibitory effect on tumor growth and metastasis in photo-immunotherapy

Yu, Xueping; Wang, Xiupeng; Yamazaki, Atsushi

doi:10.1016/j.colsurfb.2023.113314

Cited by 1 publication

(1 citation statement)

References 52 publications

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“…Nanoplatforms provide the possibility to prolong the retention of CpG ODNs inside the body, enhance the cellular uptake efficiency of CpG ODNs by immune cells, further protect CpG ODNs from nuclease degradation, and improve the therapeutic efficacy [ 13 ]. Especially, the optimization of nanoplatforms may realize the codelivery of immunostimulants and tumor antigens into the same antigen-presenting cells, reduce the non-specific immune stimulation, minimize side effects, and thus enhance the tumor antigen-specific immune response [ 4 , 5 , 20 ]. Metal–organic nanoplatforms built from metal ions/cluster nodes and organic ligands are promising for the codelivery of immunostimulants and tumor antigens due to their adjustable composition, porous structure, versatile functional groups, strong biomolecules loading ability, and biodegradability [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effects of Metal–Organic Nanoplatform and Guanine Quadruplex-Based CpG Oligodeoxynucleotides in Therapeutic Cancer Vaccines with Different Tumor Antigens

Li,

Ebara,

Shirahata

et al. 2024

Vaccines

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Oligodeoxynucleotides (ODNs) containing unmethylated cytosine–phosphate–guanosine (CpG) motifs are readily recognized by Toll-like receptor 9 on immune cells, trigger an immunomodulatory cascade, induce a Th1 -biased immune milieu, and have great potential as an adjuvant in cancer vaccines. In this study, a green one-step synthesis process was adopted to prepare an amino-rich metal–organic nanoplatform (FN). The synthesized FN nanoplatform can simultaneously and effectively load model tumor antigens (OVA)/autologous tumor antigens (dLLC) and immunostimulatory CpG ODNs with an unmodified PD backbone and a guanine quadruplex structure to obtain various cancer vaccines. The FN nanoplatform and immunostimulatory CpG ODNs generate synergistic effects to enhance the immunogenicity of different antigens and inhibit the growth of established and distant tumors in both the murine E.G7-OVA lymphoma model and the murine Lewis lung carcinoma model. In the E.G7-OVA lymphoma model, vaccination efficiently increases the CD4+, CD8+, and tetramer+CD8+ T cell populations in the spleens. In the Lewis lung carcinoma model, vaccination efficiently increases the CD3+CD4+ and CD3+CD8+ T cell populations in the spleens and CD3+CD8+, CD3−CD8+, and CD11b+CD80+ cell populations in the tumors, suggesting the alteration of tumor microenvironments from cold to hot tumors.

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