Mo-P4:273 Acute impairment of endothelial function (EF) by maximal treadmill exercise in claudicants (IC), and its improvement after supervised physical training

Andreozzi, Giuseppe Maria; Leone, A.; Laudani, R; Deinite, G.; Martini, Romeo

doi:10.1016/s1567-5688(06)80406-x

Cited by 32 publications

(45 citation statements)

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“…The latter effect was also observed in the early stages of the incremental treadmill test in the present study (results not presented). An enhancement of lower-limb endothelial vasodilator function is also feasible, given that aerobic exercise training has been shown to improve conduit vessel endothelial function in untrained limbs in patients with intermittent claudication [35]. Furthermore, recent evidence suggests that arm-crank exercise training can have an attenuating effect on systemic inflammatory markers [36], which could have a positive impact on systemic endothelial function [37,38].…”

Section: Discussionmentioning

confidence: 99%

Limb-specific and cross-transfer effects of arm-crank exercise training in patients with symptomatic peripheral arterial disease

et al. 2009

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Arm cranking is a useful alternative exercise modality for improving walking performance in patients with intermittent claudication; however, the mechanisms of such an improvement are poorly understood. The main aim of the present study was to investigate the effects of arm-crank exercise training on lower-limb O2 delivery in patients with intermittent claudication. A total of 57 patients with intermittent claudication (age, 70+/-8 years; mean+/-S.D.) were randomized to an arm-crank exercise group or a non-exercise control group. The exercise group trained twice weekly for 12 weeks. At baseline and 12 weeks, patients completed incremental tests to maximum exercise tolerance on both an arm-crank ergometer and a treadmill. Respiratory variables were measured breath-by-breath to determine peak VO2 (O2 uptake) and ventilatory threshold. Near-IR spectroscopy was used in the treadmill test to determine changes in calf muscle StO2 (tissue O2 saturation). Patients also completed a square-wave treadmill-walking protocol to determine VO2 kinetics. A total of 51 patients completed the study. In the exercise group, higher maximum walking distances (from 496+/-250 to 661+/-324 m) and peak VO2 values (from 17.2+/-2.7 to 18.2+/-3.4 ml.kg-1 of body mass.min-1) were recorded in the incremental treadmill test (P<0.05). After training, there was also an increase in time to minimum StO2 (from 268+/-305 s to 410+/-366 s), a speeding of VO2 kinetics (from 44.7+/-10.4 to 41.3+/-14.4 s) and an increase in submaximal StO2 during treadmill walking (P<0.05). There were no significant changes in the control group. The results suggest that the improvement in walking performance after arm-crank exercise training in patients with intermittent claudication is attributable, at least in part, to improved lower-limb O2 delivery.

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Section: Discussionmentioning

confidence: 99%

Limb-specific and cross-transfer effects of arm-crank exercise training in patients with symptomatic peripheral arterial disease

et al. 2009

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“…It is probable that moderate hemodynamic stress reduces the levels of inflammatory markers and increases flow-mediated vasodilation by ischemic preconditioning. In patients with CAD, it has been shown that increased walking ability is associated with improved LVEF [14,15] . The recently published study of Bøtker et al [16] has provided a promising result, showing that RIPC before hospital admission in the setting of ACS protects LV function.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Chronic Repetitive Leg Ischemia on Left Ventricular Function and Severity of Coronary Atherosclerosis in Patients with Acute Coronary Syndrome

Gungor

Yıldırım²

2017

Med Princ Pract

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Objective: The purpose of this study was to assess the impact of the presence of peripheral arterial disease (PAD) on left ventricular (LV) function in patients with coronary artery disease (CAD) presenting with acute coronary syndrome (ACS). Subjects and Methods: The medical records of the patients who were referred to Ankara Bayindir Hospital, Ankara, Turkey, due to a first episode of ACS were reviewed. Patients with concomitant PAD and CAD (group 1) were compared with those who had CAD only (group 2). The Mann-Whitney U and χ² tests were used to compare continuous and categorical variables, respectively. Results: Baseline demographic data of 53 patients with PAD + CAD (42 men and 11 women; mean age 62.5 ± 9.5 years) and a group of 60 patients with CAD only (41 men and 19 women; mean age 59.9 ± 9.8 years) were similar, except for the serum creatinine level which was higher in group 1 than in group 2 (1.32 ± 0.34 vs. 1.03 ± 0.22 mg/dL, p < 0.001). Patients with CAD + PAD had significantly higher Gensini scores (62.6 ± 19.7 vs. 41.4 ± 26.8, p = 0.004) and more 3-vessel disease than patients with CAD alone (62.2 vs. 31.6%, p < 0.045). There was a significant difference between the 2 groups regarding the LV ejection fraction at the time of the diagnosis (52.0 ± 8.2% in the CAD + PAD group and 43.7 ± 13.3% in the CAD-alone group; p = 0.017). Conclusion: CAD concomitant with PAD was associated with preserved LV function at early stages of diagnosis in patients with ACS.

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“…De fato, o braço aferente do reflexo pressor tem sua origem nas fibras III e IV do músculo esquelético e essas fibras são estimuladas pela contração, principalmente, em condições isquêmicas 13 . Outra hipótese é que a disfunção endotelial e os agentes pró-inflamatórios, que são mais acentuados nesses pacientes 20,21 , tenham atenuado a vasodilatação da musculatura ativa, aumentando, por consequência a PAD.…”

Section: Discussionunclassified

Respostas cardiovasculares ao teste ergométrico em indivíduos com claudicação intermitente. DOI: 10.5007/1980-0037.2011v13n3p208

Cucato

Rodrigues

Farah

et al. 2011

Rev. Bras. Cineantropom. Desempenho Hum.

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Resumo -Estudos sugerem que pacientes com claudicação intermitente (CI) apresentam respostas hemodinâmicas alteradas durante o teste ergométrico. Contudo, o impacto da severidade da doença nessas respostas ainda não está claro. Em vista disso, o presente estudo analisou o impacto da severidade dos sintomas de CI nas respostas cardiovasculares ao teste de esforço, em indivíduos com doença arterial obstrutiva periférica. Participaram do estudo 47 sujeitos com CI. Foi realizado teste ergométrico em esteira, utilizando protocolo específico para essa população. A amostra foi dividida em três grupos de acordo com a distância obtida no teste de esforço em: 1º tercil, caminhavam entre 210 e 420 metros; 2º tercil, caminhavam entre 450 e 700 metros; e 3º tercil, caminhavam entre 740 e 1060 metros. A pressão arterial sistólica (PAS) e diastólica (PAD), a frequência cardíaca (FC) e o duplo produto (DP) foram obtidos em repouso, no primeiro estágio e no pico de esforço. Nos três tercis, a PAS e a PAD aumentaram significantemente ao longo do teste ergomé-trico. Nos três tercis, a FC e o DP aumentaram significantemente ao longo do teste e as respostas no 1º tercil foram mais acentuadas que nos demais tercis. Todavia, no pico de esforço, a FC e o DP não houve diferença entre os tercis. Concluíu-se que a severidade da CI não influenciou as respostas da pressão arterial durante o teste ergométrico progressivo, ao passo que maiores valores de FC e DP foram observados em indivíduos com CI mais severa em uma carga submáxima. Palavras-chave: Claudicação intermitente; Caminhada; Teste de esforço. Abstract -Studies suggest that patients with intermittent claudication (IC) present abnormal cardiovascular responses during treadmill exercise. However, it remains unclear whether this response is influenced by the severity of the disease. The objective of this study was to analyze the impact of IC severity on cardiovascular responses to an exercise test in subjects with

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Mo-P4:273 Acute impairment of endothelial function (EF) by maximal treadmill exercise in claudicants (IC), and its improvement after supervised physical training

Cited by 32 publications

References 0 publications

Limb-specific and cross-transfer effects of arm-crank exercise training in patients with symptomatic peripheral arterial disease

Limb-specific and cross-transfer effects of arm-crank exercise training in patients with symptomatic peripheral arterial disease

The Impact of Chronic Repetitive Leg Ischemia on Left Ventricular Function and Severity of Coronary Atherosclerosis in Patients with Acute Coronary Syndrome

Respostas cardiovasculares ao teste ergométrico em indivíduos com claudicação intermitente. DOI: 10.5007/1980-0037.2011v13n3p208

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