Mo1055 Clinical Features Associated With Radiological Response to Sorafenib Therapy for Unresectable Hepatocellular Carcinoma; A Multicenter Study in Japan

Characteristics of 18 patients with hepatocellular carcinoma who obtained a complete response after treatment with sorafenib

“…These characteristics consisted of a higher sensitivity to sorafenib in women with a lower bodyweight, a smaller tumor burden, a lower initial dose of sorafenib and specific adverse events, suggesting a biological basis for this phenomenon. The latest large-sale multicenter observational study in Japan suggested female sex may be one of the independent predictors of a good response to sorafenib, 17 which may lend support to our results. Understanding the characteristics that are common to patients who achieve a CR may help to elucidate the mechanisms that underlie the response to sorafenib.…”