Moandaensine, a dimeric indole alkaloid from Strychnos moandaensis (Loganiaceae)

Verpoorte, Robert; Frédérich, Michel; Delaude, Clément; Angenot, Luc; Dive, Georges; Thépenier, Philippe; Jacquier, Marie-José; Zèches-Hanrot, Monique; Lavaud, Catherine

doi:10.1016/j.phytol.2010.02.005

Cited by 11 publications

(11 citation statements)

References 11 publications

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“…[41] The bisindole alkaloid 10 (IC 50 : 7 nM), isolated from the leaves of GHA and CQR W2 strains of P. falciparum, and the activity was lower than that of chloroquine (IC 50 : 0.011 and 0.284 µM) and quinine (IC 50 : 0.269 and 0.413 µM). [43] The bisnicalaterine C (12; IC 50 : 50 nM) isolated from Hunteria zeylanica, exhibited excellent antiplasmodial activity against CQS 3D7 strain of P. falciparum, and nontoxicity toward HL-60 cells (CC 50 :…”

Section: Indole Alkaloidsmentioning

confidence: 99%

“…Moandaensine ( 11 ; IC 50 : 11.2 and 9.2 µM), a bisindole alkaloid isolated from Strychnos moandaensis (Loganiaceae), showed moderate activity against CQS FCA 20 GHA and CQR W2 strains of P. falciparum , and the activity was lower than that of chloroquine (IC 50 : 0.011 and 0.284 µM) and quinine (IC 50 : 0.269 and 0.413 µM). [ 43 ]…”

Section: Indole Alkaloidsmentioning

confidence: 99%

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The antimalarial activity of indole alkaloids and hybrids

Sun

et al. 2020

Archiv der Pharmazie

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Malaria, caused by the genus Plasmodium, remains a global public health concern. It is estimated by the World Health Organization that over 40% of the world's population lives in areas at risk for malarial transmission, and around half a million people succumb to this infectious disease annually, which is related to the rapid spread of drug-resistant parasite strains. Indole derivatives, which possess broadspectrum pharmacological properties, play a crucial role in the discovery of new drugs. Many indole derivatives exhibited potential in vitro and in vivo activity against both drug-sensitive and drug-resistant malaria, suggesting that the indole moiety is a useful template for the development of novel antimalarial agents.

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Section: Indole Alkaloidsmentioning

confidence: 99%

Section: Indole Alkaloidsmentioning

confidence: 99%

The antimalarial activity of indole alkaloids and hybrids

Sun

et al. 2020

Archiv der Pharmazie

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“…For instance, phenolic compounds protect against oxidative burst, and also have therapeutic effects for atherosclerosis. Alkaloids are the most diverse group among secondary metabolites, which have been identified in plants that belong to botanical families such as Apocynaceae, Loganiaceae, and Rubiaceae (Kato et al 2002;Cragg et al 2010;Mesia et al 2010;Verpoorte et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Arbuscular mycorrhizal fungi and potassium bicarbonate enhance the foliar content of the vinblastine alkaloid in Catharanthus roseus

et al. 2011

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Vinca (Catharanthus roseus (L.) G. Don.)is an important medicinal plant species from which antineoplastic alkaloids such as vinblastine are extracted. However, neither abiotic stress nor inoculation of arbuscular mycorrhizal fungi (AMF) has been evaluated on the accumulation of vinca alkaloids under controlled conditions. This study evaluated the effects of AMF and/or abiotic stress induced by the application of potassium bicarbonate (KHCO 3 ) and/or sodium chloride (NaCl) on plant growth, and on total content of phenolic compounds (TCPC), total antioxidant activity (TAOX), and total content of vinblastine alkaloid in leaves of vinca. TCPC, TAOX, and vinblastine were measured via spectrophotometric methods. After 75 days under greenhouse conditions, either the AMF inoculation without abiotic stress or the application of KHCO 3 (2.5 and 7.5 mM) resulted in significantly (P≤0.001) enhanced plant growth, TCPC, TAOX, and total content of vinblastine. The application of NaCl significantly diminished plant growth, but did not stimulate the content of vinblastine. The combined application of NaCl and KHCO 3 significantly decreased AMF-colonization in roots. The sole inoculation of AMF or the single application of 7.5 mM KHCO 3 induced the accumulation of vinblastine in leaves of vinca.

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“…In addition, bearing in mind that several species of organisms are associated with cyanobacteria and bacteria, it is considered that several natural products originating in microorganisms can be isolated from marine animals [ 9 ]. Indole alkaloids have been shown to exhibit a wide array of biological activities such as opioid receptor agonistic [ 10 ], antibacterial [ 11 , 12 ], antifungal [ 13 , 14 ], anti-inflammatory [ 15 ], antileishmanial [ 16 , 17 ], antiplasmodial [ 18 , 19 ], anti-HIV [ 20 ], cytotoxic [ 21 ], glucose uptake stimulatory [ 22 ], larvicidal [ 23 ], trypanocidal [ 24 ], and vasodilator [ 25 , 26 ] and inhibition of cholinesterase [ 27 ], indoleamine-2, 3-dioxygenase [ 28 ], calmodulin [ 29 ], and CB1 cannabinoid receptor [ 30 ]. Infectious diseases caused by bacteria, fungi, viruses, and parasites are still a major threat to public health, despite the tremendous progress in human medicine.…”

Section: Introductionmentioning

confidence: 99%

Indole Alkaloids from Marine Sources as Potential Leads against Infectious Diseases

França

Barbosa

Silva

et al. 2014

BioMed Research International

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Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources. Infectious diseases remain a major threat to public health, and in the absence of long-term protective vaccines, the control of these infectious diseases is based on a small number of chemotherapeutic agents. Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents. In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.

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Moandaensine, a dimeric indole alkaloid from Strychnos moandaensis (Loganiaceae)

Cited by 11 publications

References 11 publications

The antimalarial activity of indole alkaloids and hybrids

The antimalarial activity of indole alkaloids and hybrids

Arbuscular mycorrhizal fungi and potassium bicarbonate enhance the foliar content of the vinblastine alkaloid in Catharanthus roseus

Indole Alkaloids from Marine Sources as Potential Leads against Infectious Diseases

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