Modafinil augments brain activation associated with reward anticipation in the nucleus accumbens

Funayama, Takuya; Ikeda, Yumiko; Tateno, Amane; Takahashi, Hidehiko; Okubo, Yoshiro; Fukayama, Haruhisa; Suzuki, Hidenori

doi:10.1007/s00213-014-3499-0

Cited by 20 publications

(17 citation statements)

References 53 publications

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“…Specifically, the AI receives input from multiple regions such as the VTA, VS, and amygdala (Cauda et al, 2012) and integrates this information to represent the reward or loss saliency of the stimuli (Critchley et al, 2013;Pizzagalli et al, 2009). Accordingly, the AI is consistently involved in the anticipation of both reward and loss (Bjork et al, 2010b;Enzi et al, 2012a, b;Funayama et al, 2014;Van Duin et al, 2016). In addition, the AI has been frequently involved in detecting the salience of social stimuli or events (Feng et al, 2015;Luo et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…In particular, the VS plays a key role in encoding expected positive incentive value (Abler et al, 2006;Bjork et al, 2010aBjork et al, , 2008aKnutson et al, 2001a;Mucci et al, 2015). Moreover, monetary reward anticipation further engages the anterior insula (AI) and dorsal anterior cingulate cortex/supplementary motor area (dACC/SMA), which are implicated in signaling salience of an upcoming event (Funayama et al, 2014;Kirk et al, 2015;Kollmann et al, 2017;Oldham et al, 2018;Wilson et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Love is analogous to money in human brain: Coordinate-based and functional connectivity meta-analyses of social and monetary reward anticipation

Huang

Camilleri

et al. 2019

Neuroscience & Biobehavioral Reviews

102

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Both social and material rewards play a crucial role in daily life and function as strong incentives for various goal-directed behaviors. However, it remains unclear whether the incentive effects of social and material reward are supported by common or distinct neural circuits. Here, we have addressed this issue by quantitatively synthesizing and comparing neural signatures underlying social (21 contrasts, 207 foci, 696 subjects) and monetary (94 contrasts, 1083 foci, 2060 subjects) reward anticipation. We demonstrated that social and monetary reward anticipation engaged a common neural circuit consisting of the ventral tegmental area, ventral striatum, anterior insula, and supplementary motor area, which are intensively connected during both task and resting states. Functional decoding findings indicate that this generic neural pathway mediates positive value, motivational relevance, and action preparation during reward anticipation, which together motivate individuals to prepare well for the response to the upcoming target. Our findings support the *

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Love is analogous to money in human brain: Coordinate-based and functional connectivity meta-analyses of social and monetary reward anticipation

Huang

Camilleri

et al. 2019

Neuroscience & Biobehavioral Reviews

102

View full text Add to dashboard Cite

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“…All participants completed a Japanese version of the MID task based on the original version . The MID task consisted of 90 trials.…”

Section: Methodsmentioning

confidence: 99%

Differences in neural responses to reward and punishment processing between anorexia nervosa subtypes: An fMRI study

Murao

Sugihara

Isobe

et al. 2017

Psychiatry Clin Neurosci

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AN-bp patients showed altered neural responses to punishment in brain regions implicated in emotional arousal. Our findings suggest that individuals with AN-bp are more sensitive to potential punishment than individuals with AN-r and healthy individuals at the neural level. The present study provides preliminary evidence that there are neurobiological differences between AN subtypes with regard to the reward system, especially punishment processing.

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“…Several methods have been proposed to investigate the CNS effects of modafinil in human ( Ellis et al, 1999 ; Spence et al, 2005 ; Hunter et al, 2006 ; Thomas and Kwong, 2006 ; Kim et al, 2007 ; Joo et al, 2008a ; Minzenberg et al, 2008 ; Rasetti et al, 2010 ; Ghahremani et al, 2011 ; Minzenberg et al, 2011 ; Goudriaan et al, 2013 ; Schmaal et al, 2013 ; Funayama et al, 2014 ; Schmaal et al, 2014 ; Ikeda et al, 2017 ; Schmidt et al, 2017 ) and animals ( Engber et al, 1998 ; van Vliet et al, 2008 ; Dawson et al, 2012 ; Gozzi et al, 2012 ), including fMRI, 2-deoxyglucose autoradiography, FDG PET, and cerebral blood flow assesement using single-photon emission computed tomography. These data tend towards a consensus over cortical and subcortical brain activations induced by modafinil including hypothalamic and thalamic regions ( Thomas and Kwong, 2006 ; Gozzi et al, 2012 ), which are highly involved in the regulation of sleep-wake cycle ( Szabadi, 2006 ; Lin et al, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Cortico-Amygdala-Striatal Activation by Modafinil/Flecainide Combination

Vodovar

Duchêne

Wimberley

et al. 2018

International Journal of Neuropsychopharmacology

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BackgroundModafinil, a nonamphetaminic wake-promoting compound, is prescribed as first line therapy in narcolepsy, an invalidating disorder characterized by excessive daytime sleepiness and cataplexy. Although its mode of action remains incompletely known, recent studies indicated that modafinil modulates astroglial connexin-based gap junctional communication as administration of a low dose of flecainide, an astroglial connexin inhibitor, enhanced the wake-promoting and procognitive activity of modafinil in rodents and healthy volunteers. The aim of this study is to investigate changes in glucose cerebral metabolism in rodents, induced by the combination of modafinil+flecainide low dose (called THN102).MethodsThe impact of THN102 on brain glucose metabolism was noninvasively investigated using 18F-2-fluoro-2-deoxy-D-glucose Positron Emission Tomography imaging in Sprague-Dawley male rats. Animals were injected with vehicle, flecainide, modafinil, or THN102 and further injected with 18F-2-fluoro-2-deoxy-D-glucose followed by 60-minute Positron Emission Tomography acquisition. 18F-2-fluoro-2-deoxy-D-glucose Positron Emission Tomography images were coregistered to a rat brain template and normalized from the total brain Positron Emission Tomography signal. Voxel-to-voxel analysis was performed using SPM8 software. Comparison of brain glucose metabolism between groups was then performed.ResultsTHN102 significantly increased regional brain glucose metabolism as it resulted in large clusters of 18F-2-fluoro-2-deoxy-D-glucose uptake localized in the cortex, striatum, and amygdala compared with control or drugs administered alone. These regions, highly involved in the regulation of sleep-wake cycle, emotions, and cognitive functions were hence quantitatively modulated by THN102.ConclusionData presented here provide the first evidence of a regional brain activation induced by THN102, currently being tested in a phase II clinical trial in narcoleptic patients.

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Modafinil augments brain activation associated with reward anticipation in the nucleus accumbens

Abstract: The present study showed that modafinil affects reward processing in the NAc in healthy subjects through enhancing more positive anticipation, and it may provide a basis for the use of this drug for treating anhedonia observed in psychiatric disorders.

Cited by 20 publications

References 53 publications

Love is analogous to money in human brain: Coordinate-based and functional connectivity meta-analyses of social and monetary reward anticipation

Love is analogous to money in human brain: Coordinate-based and functional connectivity meta-analyses of social and monetary reward anticipation

Differences in neural responses to reward and punishment processing between anorexia nervosa subtypes: An fMRI study

Cortico-Amygdala-Striatal Activation by Modafinil/Flecainide Combination

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