Modality and sex differences in pain sensitivity during human endotoxemia

Karshikoff, Bianka; Lekander, Mats; Soop, Anne; Lindstedt, Folke; Ingvar, Martin; Kosek, Eva; Höglund, Caroline Olgart; Axelsson, John

doi:10.1016/j.bbi.2014.11.014

Cited by 89 publications

(86 citation statements)

References 64 publications

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“…In Sothern 1995 [17], 7 values out of 88 (8%), ranging from 0.5 to 0.96 pg/ml, were re-coded to 1 pg/ml. In Karshikoff 2015 [18], 23 values out of 83 (28%), ranging from 0.01 to 0.88 pg/ml, were re-coded to 0.9 pg/ml.…”

Section: Methodsmentioning

confidence: 99%

Diurnal Variation of Circulating Interleukin-6 in Humans: A Meta-Analysis

et al. 2016

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The pleiotropic cytokine interleukin-6 (IL-6) has been proposed to contribute to circadian regulation of sleepiness by increasing in the blood at night. Earlier studies have reported diurnal variation of IL-6, but phase estimates are conflicting. We have therefore performed a meta-analysis on the diurnal variation of circulating IL-6. Studies were included if they reported IL-6 in plasma or serum recorded at least twice within 24 hours in the same individual. A systematic search resulted in the inclusion of 43 studies with 56 datasets, for a total of 1100 participants. Individual participant data were available from 4 datasets with a total of 56 participants. Mixed-effects meta-regression modelling confirmed that IL-6 varied across the day, the most conspicuous effect being a trough in the morning. These results stand in contrast to earlier findings of a peak in the evening or night, and suggest that diurnal variation should be taken into account in order to avoid confounding by time of day in studies of IL-6 in plasma or serum.

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Section: Methodsmentioning

confidence: 99%

Diurnal Variation of Circulating Interleukin-6 in Humans: A Meta-Analysis

et al. 2016

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“…The stimulus material consisted of films of six walking healthy males (mean age 22 ± 1 years), who had taken part in a doubleblind, placebo-controlled randomized crossover study with two conditions: intravenous injection of 0.8 ng/kg body weight Escherichia coli LPS and saline (placebo) (as described in detail in Karshikoff et al 2014). The walkers were injected with LPS and placebo on two different occasions, and were similarly groomed and filmed 75 min after injection in each condition.…”

Section: Stimulus Acquisitionmentioning

confidence: 99%

Sick man walking: Perception of health status from body motion

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Karshikoff

Axelsson

et al. 2015

Brain, Behavior, and Immunity

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“…Alterations in inflammatory processes have been hypothesized as contributor to pain (Watkins and Maier 2005). During acute activation of the immune system, cytokines are known to induce a number of behavioral symptoms, one of which is pain sensitization (Dantzer et al 2008), and the cytokine interleukin (IL)-8 has been associated with the acute development of hyperalgesia in both rodents and humans (Cunha et al 1991; Karshikoff et al 2015). In addition, low-grade increase in systemic concentrations of inflammatory markers, including IL-6, IL-8 and tumor necrosis factor (TNF)-α, have been observed in patients with chronic pain (Gur and Oktayoglu 2008; Kadetoff et al 2012; Koch et al 2007; Parkitny et al 2013; Wang et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults

et al. 2016

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The purpose of the present pilot study was to explore the moderating role of basal inflammation on the effects of behavioral pain treatment in 41 patients with long-standing pain. Baseline pro-inflammatory status moderated behavioral treatment outcomes: higher pre-treatment levels of Tumor Necrosis Factor (TNF)-α and Interleukin (IL)-6 were related to less improvement in pain intensity, psychological inflexibility and in mental health-related quality of life. The treatment outcomes improved in the subgroup that had low levels of pro-inflammatory cytokines at baseline, while the subjects with higher pro-inflammatory status did not. Altogether, results indicate that low-grade inflammation may influence the behavioral treatment outcomes and provide a possible explanation of the heterogeneity in treatment response.

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Modality and sex differences in pain sensitivity during human endotoxemia

Cited by 89 publications

References 64 publications

Diurnal Variation of Circulating Interleukin-6 in Humans: A Meta-Analysis

Diurnal Variation of Circulating Interleukin-6 in Humans: A Meta-Analysis

Sick man walking: Perception of health status from body motion

Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults

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