Modality‐specific axonal projections in the CNS of the flies <i>Phormia</i> and <i>Drosophila</i>

Murphey, R. K.; Possidente, Debra; Pollack, Gerald S.; Merritt, David J.

doi:10.1002/cne.902900203

Cited by 114 publications

(92 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Murphey et al (1989) stained tarsal hairs of both Phormia and Drosophila with CoCl 2 , and found similar results for the two species. The hairs project to the ventral leg neuropil, with the cells from each hair falling into at least three morphological classes (Fig.…”

Section: Projections Of Gustatory Neurons Into the Central Nervous Sysupporting

confidence: 61%

Taste sensilla of flies: Function, central neuronal projections, and development

Pollack

Balakrishnan

1997

Microsc. Res. Tech.

View full text Add to dashboard Cite

Taste sensilla of flies are composed of only a few cells, all of which have different functions. Depending on the species and on the sensillum type, there are from 2-5 neurons, each of which has its own stimulus specificity, and each of which makes a different contribution to the fly's behavior. In addition, taste sensilla include several nonneuronal cells that are important both for the development of the sensillum and for its functioning. The component cells of a sensillum derive from a single epidermal precursor according to a stereotyped sequence of mitoses. This review focuses on the different phenotypes of the component cells of taste sensilla, particularly the stimulus sensitivity and central neuronal anatomy of the receptor neurons, and on the development of this multicellular organ from a single precursor cell.

show abstract

Section: Projections Of Gustatory Neurons Into the Central Nervous Sysupporting

confidence: 61%

Taste sensilla of flies: Function, central neuronal projections, and development

Pollack

Balakrishnan

1997

Microsc. Res. Tech.

View full text Add to dashboard Cite

show abstract

“…Additionally, class II neurons, with their collateral branches, might provide information to distinct central circuits. The class I neurons targeted a more dorsal region of the neuropil, which is generally a characteristic of proprioceptive afferents in insects (Merritt and Murphey, 1992;Murphey et al, 1989;Pfluger et al, 1988;Schrader and Merritt, 2000). Indeed, a class of da neurons in Manduca has been shown to target dorsal neuropil, and to respond to stretch of the cuticle (Grueber et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…Axons of tactile receptors typically project to ventral areas of the neuropil, whereas strainsensing or proprioceptive neurons usually project to more dorsal regions (Murphey et al, 1989;Pfluger et al, 1988). Fasciclin IIlabeled axon tracts provide a frame of reference for assessing dorsoventral (DV) position in the CNS ( Fig.…”

Section: Dorsoventral Distinctions Between Axon Terminalsmentioning

confidence: 99%

Projections ofDrosophilamultidendritic neurons in the central nervous system: links with peripheral dendrite morphology

et al. 2007

View full text Add to dashboard Cite

Neurons establish diverse dendritic morphologies during development, and a major challenge is to understand how these distinct developmental programs might relate to, and influence, neuronal function. Drosophila dendritic arborization (da) sensory neurons display class-specific dendritic morphology with extensive coverage of the body wall. To begin to build a basis for linking dendrite structure and function in this genetic system, we analyzed da neuron axon projections in embryonic and larval stages. We found that multiple parameters of axon morphology, including dorsoventral position, midline crossing and collateral branching, correlate with dendritic morphological class. We have identified a class-specific medial-lateral layering of axons in the central nervous system formed during embryonic development, which could allow different classes of da neurons to develop differential connectivity to second-order neurons. We have examined the effect of Robo family members on class-specific axon lamination, and have also taken a forward genetic approach to identify new genes involved in axon and dendrite development. For the latter, we screened the third chromosome at high resolution in vivo for mutations that affect class IV da neuron morphology. Several known loci, as well as putative novel mutations, were identified that contribute to sensory dendrite and/or axon patterning. This collection of mutants, together with anatomical data on dendrites and axons, should begin to permit studies of dendrite diversity in a combined developmental and functional context, and also provide a foundation for understanding shared and distinct mechanisms that control axon and dendrite morphology.

show abstract

“…Studies using conventional dye labeling techniques in Dipterans (Drosophila and Phormia) and Orthopterans (grasshopper and locust) have identified the ventral neuropil as the target region for both tactile and gustatory sensory inputs from the legs while the intermediate and dorsal neuropil are the target regions for proprioceptive inputs (Murphey et al, 1989;Merritt and Murphey, 1992). Projections of the interneurons within the thoracic ganglia show the same relationship between function and target layer in the neuropil (Newland, 1990).…”

Section: The Spatial Expression Of Delta Predicts a Function In Formamentioning

confidence: 99%

Delta expression in post‐mitotic neurons identifies distinct subsets of adult‐specific lineages in Drosophila

Cornbrooks

Bland

Williams

et al. 2006

Developmental Neurobiology

View full text Add to dashboard Cite

ABSTRACT:The Drosophila ventral nerve cord is comprised of numerous neuronal lineages, each derived from a stereotypically positioned neuroblast (NB). At the embryonic stage the unique identities of each NB, and several of their neuronal progeny, are well characterized by spatial and temporal expression patterns of molecular markers. These patterns of expression are not preserved at the larval stage and thus the identity of adult-specific lineages remains obscure. Recent clonal analysis using MARCM has identified 24 adult-specific lineages arising from thoracic NBs at the larval stage. In this study, we have explored a role for the Delta protein in development of the post-embryonic Drosophila ventral nerve cord. We find that Delta expression identifies 7 of the 24 adult-specific lineages of the thoracic ganglia by being highly enriched in clusters of newly born postmitotic neurons and their neurite bundles. The Delta lineages constitute the majority of bundles projecting to the ventral neuropil, consistent with a role in processing leg sensory information. Targeted knockdown of Delta in neurons using RNAi results in significantly decreased leg chemosensory response and a relatively unaffected leg mechanosensory response. Delta RNAi knockdown in Delta lineages also gives a more diffuse bundle terminal morphology while the overall path-finding of neurite bundles is unaffected. We also identify a male-specific Delta lineage in the terminal abdominal ganglia, implicating a role for Delta in development of sexually dimorphic neural networks. Examples of Delta-expressing neurites contacting Notch-expressing glia are also seen, but are not common to all Delta lineages. Altogether, these data reveal a fundamental pattern of Delta expression that is indicative of an underlying developmental program that confers identity to adult lineage neurons. '

show abstract

Modality‐specific axonal projections in the CNS of the flies Phormia and Drosophila

Cited by 114 publications

References 28 publications

Taste sensilla of flies: Function, central neuronal projections, and development

Taste sensilla of flies: Function, central neuronal projections, and development

Projections ofDrosophilamultidendritic neurons in the central nervous system: links with peripheral dendrite morphology

Delta expression in post‐mitotic neurons identifies distinct subsets of adult‐specific lineages in Drosophila

Contact Info

Product

Resources

About