Model-based approach for analyzing prevalence of nuclear cataracts in elderly residents

Kodera, Sachiko; Hirata, Akimasa; Miura, Fumiaki; Rashed, Essam A.; Hatsusaka, Natsuko; Yamamoto, Naoki; Kubo, Eri; Sekiya, Hiroshi

doi:10.1016/j.compbiomed.2020.104009

Cited by 11 publications

(6 citation statements)

References 80 publications

(119 reference statements)

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“…In our previous research, using a large-scale integrated computational method, we found that the eye lens temperature may reach 37.0-37.5°C or higher with increasing environmental temperature. By setting the threshold of the lens temperature at 37.0°C, we found a positive correlation between the cumulative heat load, which is an indicator of the cumulative temperature difference above 37°C and nuclear cataract incidence for 10 years; we also found an association between the time course of the mean lens temperature rise and nuclear cataract incidence ( 11 ). Thus, long-term exposure to a high-temperature environment may increase the risk of nuclear cataract development.…”

Section: Introductionmentioning

confidence: 68%

“…The estimated temperature of the crystalline lens is affected by the ambient temperature (surface temperature) around the eye and core temperature of the body. Therefore, in our previous study ( 11 ), simulation analysis using a supercomputer based on the biothermal transport equation was performed in a model with an eye tissue resolution of 1 mm based on the Japanese body model developed by the National Institute of Information and Communications Technology ( 28 ). The results showed that simulated lens temperatures ranged from 35.0 to 37.5°C at ambient eye temperatures of 19 to 35°C in a typical environment.…”

Section: Discussionmentioning

confidence: 99%

“…iHLEC-NY2 cells were cultured in high-glucose DMEM containing 10% FBS, 10 ng/ml basic fibroblast growth factor, 100× minimum essential medium non-essential amino acids, 100× GlutaMAX™ (Thermo Fisher Scientific), and penicillin-streptomycin solution. In computer simulations, when the ambient temperature was 19–35°C, the estimated lens temperature was 35.0-37.5°C ( 11 ). We previously reported that the prevalence of nuclear cataracts is significantly higher in tropical regions than in temperate regions ( 9 , 10 , 23 ).…”

Section: Methodsmentioning

confidence: 99%

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Function of mitochondrial cytochrome c oxidase is enhanced in human lens epithelial cells at high temperatures

et al. 2022

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Enhancement of density via human lens epithelium (HLE) cell proliferation is the underlying cause of nuclear cataracts. Moreover, our previous epidemiological study demonstrated that the risk of nuclear cataract development is significantly higher under elevated environmental temperatures compared with under lower temperatures. The present study investigated the relationship between temperature and cell proliferation in terms of mitochondrial function, which is a nuclear cataract-inducing risk factor, using two different HLE cell lines, SRA01/04 and immortalized human lens epithelial cells NY2 (iHLEC-NY2). Cell proliferation was significantly enhanced under the high-temperature condition (37.5˚C) in both cell lines. The cell growth levels of SRA01/04 and iHLEC-NY2 cells cultured at 37.5˚C were 1.20-and 1.16-fold those in the low-temperature cultures (35.0˚C), respectively. Moreover, the levels of cytochrome c oxidase mRNA (mitochondrial genome, cytochrome c oxidase-1-3) and its activity in SRA01/04 and iHLEC-NY2 cells cultured at 37.5˚C were higher compared with those in cells cultured at 35.0˚C. In addition, adenosine-5'-triphosphate (ATP) levels in SRA01/04 and iHLEC-NY2 cells were also significantly higher at 37.5˚C compared with those at 35.0˚C. By contrast, no significant differences in Na + /K + -ATPase or Ca 2+ -ATPase activities were observed between HLE cells cultured at 35.0 and 37.5˚C. These results suggested that expression of the mitochondrial genome was enhanced in high-temperature culture, resulting in a sufficient ATP content and cell proliferation for lens opacity. Therefore, elevated environmental temperatures may increase the risk of nuclear cataracts caused by HLE cell proliferation via mitochondrial activation.

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Section: Introductionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Function of mitochondrial cytochrome c oxidase is enhanced in human lens epithelial cells at high temperatures

et al. 2022

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“…In a study by Kodera et al, they computed the change in lens temperature as a result of exposure to ambient conditions in people 50 to 60 years of age living in tropical and temperate regions. It was observed that a strong correlation existed between the prevalence of nuclear cataracts and the computed cumulative thermal dose in the lens ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

Associations of Humidity and Temperature With Cataracts Among Older Adults in China

Gao

et al. 2022

Front. Public Health

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BackgroundThe burden of cataracts was substantial in the current aging world. However, few epidemiological studies have examined the associations between climate and weather conditions and cataract in older populations. We aimed to investigate the associations of air relative humidity and temperature with cataracts in older adults in China.MethodsWe used the cohort data from 2002, 2005, 2008, 2011, 2014, and 2018 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). A total of 62,595 Chinese older adults aged between 65 and 105 years were included in the analyses. City-level annual average air humidity and temperature during 2001 and 2017 (before the survey year) was used to measure population exposure. A cataract was self-reports based on the medical record or the doctor's diagnosis and 8,071 older adults had cataract. Covariates included socio-demographic, health status, lifestyles, and chronic conditions. We adopted the Generalized estimation equation (GEE) model to analyze the associations of relative humidity and temperature with cataracts.ResultsWe found that the average relative humidity (OR: 0.99; 95% CI: 0.98–0.99) in the past year was inversely associated with cataract likelihoods in older adults and a positive association between temperature (OR: 1.04; 95%CI: 1.03,1.05) in the past year and cataract likelihoods in older adults. The associations were robust in stratified analyses by sex, urban/rural residence, and education level. Furthermore, we found a nonlinear J-shaped relationship between temperature and cataract prevalence.ConclusionOur findings provide the evidence that higher temperature and low relative humidity may be associated with cataracts in older adults.

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“…Our previous study provided a full explanation of our inhouse computational code developed at the Nagoya Institute of Technology [44], [46]. The human model's thermoregulation was assumed to be similar to that of adults living in a temperate zone [46], [51], which included Nagoya City.…”

Section: B Temperature Computationmentioning

confidence: 99%

Computed and Measured Core Temperature of Patients With Heatstroke Transported From Their Homes via Ambulance

et al. 2022

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The number of patients experiencing heat-related illnesses has gradually increased due to global warming. Owing to an aging society, 50% of patients with heat-related illnesses in Japan are elderly. Core temperature is one key parameter for health care; however, its monitoring is virtually impossible. Internet of Things (IoT) devices for healthcare have been proposed; however, the vital parameters to be monitored remain controversial. Here, we assessed the core temperature of elderly patients who were transported to hospitals by ambulance from their homes. The patients' core temperatures were recorded by the Fire Department of Nagoya City in the summers of 2019 and 2020. The time course of the core temperature of each patient was then replicated using the integrated computational techniques through multiphysics analysis and thermoregulation under ambient condition data. According to the statistics, most elderly patients who were transported from their homes had a high core temperature. The measured core temperature in 31.4% of the patients was higher than the computed core temperature even assuming that there was no sweating. Assuming that the sweating function works well, the total amount of water loss was insufficient to have caused dehydration in a single day. These results suggest that successive heat stress during the preceding days should be considered to recreate the computed core temperature to match the measurement. These results were consistent with the previous finding that some elderly suffered from heatstroke successively over a few days. In the IoT-based monitoring system development, it would be informative for monitoring core temperature during the preceding days.

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Model-based approach for analyzing prevalence of nuclear cataracts in elderly residents

Cited by 11 publications

References 80 publications

Function of mitochondrial cytochrome c oxidase is enhanced in human lens epithelial cells at high temperatures

Function of mitochondrial cytochrome c oxidase is enhanced in human lens epithelial cells at high temperatures

Associations of Humidity and Temperature With Cataracts Among Older Adults in China

Computed and Measured Core Temperature of Patients With Heatstroke Transported From Their Homes via Ambulance

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