Model-based design and analysis of glucose isomerization process operation

Papadakis, Emmanouil; Pedersen, Sven; Tula, Anjan K.; Fedorova, Marina; Woodley, John M.; Gani, Rafiqul

doi:10.1016/j.compchemeng.2016.12.016

Cited by 6 publications

(4 citation statements)

References 27 publications

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“…The stability of the enzyme lends itself to immobilization, which, in turn, facilitates continuous use. Today, the entire process, including plant and factory use (with 10–20 reactors in parallel) has been optimized . The immobilization of glucose isomerase dates back more than 50 years, and all current commercial processes involve the use of an immobilized form.…”

Section: Biocatalysis Engineeringmentioning

confidence: 99%

“…Today, the entire process, including plant and factory use (with 10−20 reactors in parallel) has been optimized. 229 The immobilization of glucose isomerase dates back more than 50 years, and all current commercial processes involve the use of an immobilized form. More than 500 tons are used annually to produce ca.…”

Section: Biocatalyst Engineering: Enzyme Immobilizationmentioning

confidence: 99%

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Role of Biocatalysis in Sustainable Chemistry

2017

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Based on the principles and metrics of green chemistry and sustainable development, biocatalysis is both a green and sustainable technology. This is largely a result of the spectacular advances in molecular biology and biotechnology achieved in the past two decades. Protein engineering has enabled the optimization of existing enzymes and the invention of entirely new biocatalytic reactions that were previously unknown in Nature. It is now eminently feasible to develop enzymatic transformations to fit predefined parameters, resulting in processes that are truly sustainable by design. This approach has successfully been applied, for example, in the industrial synthesis of active pharmaceutical ingredients. In addition to the use of protein engineering, other aspects of biocatalysis engineering, such as substrate, medium, and reactor engineering, can be utilized to improve the efficiency and cost-effectiveness and, hence, the sustainability of biocatalytic reactions. Furthermore, immobilization of an enzyme can improve its stability and enable its reuse multiple times, resulting in better performance and commercial viability. Consequently, biocatalysis is being widely applied in the production of pharmaceuticals and some commodity chemicals. Moreover, its broader application will be further stimulated in the future by the emerging biobased economy.

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Section: Biocatalysis Engineeringmentioning

confidence: 99%

Section: Biocatalyst Engineering: Enzyme Immobilizationmentioning

confidence: 99%

Role of Biocatalysis in Sustainable Chemistry

2017

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“…The axial distance along the reactor and the radial co-ordinate in a fiber are the two spatial independent variables, while the time is the Fluids 2020, 5, 3 3 of 11 third independent variable. In a manner similar to earlier studies [13,14] the following phenomena are taken into account in the following analysis:…”

Section: Problem Descriptionmentioning

confidence: 99%

“…The ODEs defined by Equations (10), (11), and (14) are applicable at each node, leading to a system of N(2 + n 0 ) ODEs, which can be solved using standard ODE solvers such as ode45 or ode113 available in MATLAB.…”

Section: Of 11mentioning

confidence: 99%

Multi-Scale Modeling of the Dynamics of a Fibrous Reactor: Use of an Analytical Solution at the Micro-Scale to Avoid the Spatial Discretization of the Intra-Fiber Space

Dobri

Papathanasiou

2019

Fluids

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Direct modeling of time-dependent transport and reactions in realistic heterogeneous systems, in a manner that considers the evolution of the quantities of interest in both, the macro-scale (suspending fluid) and the micro-scale (suspended particles), is currently well beyond the capabilities of modern supercomputing. This is understandable, since even a simple system such as this can easily contain over 107 particles, whose length and time scales differ from those of the macro-scale by several orders of magnitude. While much can be gained by applying direct numerical solution to representative model systems, the direct approach is impractical when the performance of large, realistic systems is to be modeled. In this study we derive and analyze a “hybrid” model that is suitable for fibrous reactors. The model considers convection/diffusion in the bulk liquid, as well as intra-fiber diffusion and reaction. The essence of our approach is that diffusion and (first-order) reaction in the intra-fiber space are handled semi-analytically, based on well-established theory. As a result, the problem of intra-fiber transport and reaction is reduced to an easily solvable set of n 0 ODEs, where n 0 is the number of terms in the Bessel expansion evaluated without recourse to approximation; this set is coupled, point-wise, with a numerical model of the macro-scale. When the latter is discretized using N nodes, the total “hybrid” model for the system consists of a system of N ( 2 + n 0 ) ODEs, which is easily solvable on a modest workstation. Parametric analyses are presented and discussed.

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