“…However they were all designed from physical and biological equations, and very few behavioral modeling approaches of angiogenesis have been tested, so far. For instance, Drexler and Kovacs have used in [16][17][18][19][20] a state-space representation derived from a linearization process applied to a nonlinear model initially proposed in [11]. Nevertheless the relevance of this state-space model has never been assessed in vivo.…”