Model experiments of BPPV using isolated utricle and posterior semicircular canal

Inagaki, Taro; Suzuki, Mamoru; Otsuka, Koji; Kitajima, Naoharu; Furuya, Masayoshi; Ogawa, Yasuo; Takenouchi, Tsuyoshi

doi:10.1016/j.anl.2005.09.001

Cited by 28 publications

(18 citation statements)

References 9 publications

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“…This otoconial effect on the sensory cells, as testified by CAP changes, could justify the vertigo or dizziness after physical therapy. 41 These findings were confirmed by Prokopakis et al (2007) theorizing that early occurrence of RD (within 48-72 h after CRPs) might be caused by the new position acquired by the otoconial mass after the otoconial detachment. Following the CRPs, the debris re-attaches to the otolithic membrane of the utricle changing otolith pressure.…”

Section: Resultsmentioning

confidence: 58%

Residual Dizziness after Successful Repositioning Maneuver for Idiopathic Benign Paroxysmal Positional Vertigo: A Review

et al. 2017

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The benign paroxysmal positional vertigo (BPPV) is a vestibular disorder cause of vertigo. The BPPV may be corrected mechanically by repositioning maneuvers but even after successful maneuvers, some patients report residual dizziness for a certain period afterward. Early recognition and treatment might decrease the incidence of residual dizziness in patients with BPPV, especially in those patients with psychiatric comorbidities and in the elderly, lowering the risk of falling. Many pathogenetic hypotheses for residual dizziness are under debate.The purpose of this review was to identify, evaluate and review recent researches about possible causal factors involved in residual dizziness and the implications on clinical practice. A literature search was performed using different databases such as Pubmed and Scopus. The following search terms were used: residual dizziness, otolithic membrane and BPPV. The search found a total of 1192 titles, which were reduced to 963 after a procedure of de-duplication of the found titles. The research was then restricted to an interval of time comprised between 2000 and 2016 for a total of 800 titles. Among these titles, only those including the terms benign paroxysmal positional vertigo were considered eligible for this review. Only publications in English language were taken into consideration and we excluded those with not available abstract. Finally, 90 abstracts were obtained and critically evaluated by two different Authors, and additional studies were identified by hand searching from the references of artiche of interest. Only 53 were included in this work.

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Section: Resultsmentioning

confidence: 58%

Residual Dizziness after Successful Repositioning Maneuver for Idiopathic Benign Paroxysmal Positional Vertigo: A Review

et al. 2017

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“…Residual dizziness has also been reported as a complication of BPPV repositioning treatments [35,36,37]. Most of the patients in our research complained of residual dizziness immediately after the treatment, but the dizziness declined over time.…”

Section: Discussionmentioning

confidence: 47%

“…Most of the patients in our research complained of residual dizziness immediately after the treatment, but the dizziness declined over time. This symptom can be explained by a study on bullfrogs, which showed that once the otoconia return to the utricle, they change the utricular reactivity, causing dizziness after physical therapy [35]. We also interviewed the symptom-free patients to see whether they felt residual dizziness during the 1-month period after the treatments.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study on the Roles of the Number of Accelerations and Rotation Angle in the Treatment Maneuvers for Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo

Tian

Sheng

Wang

et al. 2015

ORL

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Aims: This study aims to investigate the roles of the number of accelerations and rotation angle in the treatment of posterior semicircular canal benign paroxysmal positional vertigo (PC-BPPV). Methods: We enrolled 344 patients with unilateral PC-BPPV. Of these, 167 patients in the simple-step maneuver (SSM) group were accelerated twice and rotated 120° per step, whereas 177 patients in the multi-step maneuver (MSM) group were accelerated 4 times and rotated 60° per step. Dix-Hallpike (DH) tests were performed to categorize the treatment outcome as follows: ‘symptom free' if the result was negative, ‘symptom persistent' if the result remained positive after performing the maneuver 3 times or ‘canal conversion' if horizontal nystagmus was evoked. Results: Of the patients in the SSM and MSM groups, 78.4 and 91.5% became symptom free, respectively, while canal conversion occurred in 13.8 and 5.1%, respectively (p = 0.003, χ² test). The success rate after performing the maneuver once was 57.1% in the MSM and 32.3% in the SSM symptom-free patients (p = 0.001, χ² test). One month after the treatment, 22.0 and 9.6% of the SSM and MSM patients had symptom relapse, respectively (p = 0.007, χ² test). Conclusions: More accelerations and a smaller rotation angle improved the effectiveness and efficiency of the repositioning maneuvers and reduced canal conversion.

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“…For the manipulation of the complex inner space of the temporal bone, accurate knowledge of the 3D structure is necessary. Many researchers require reliable detailed information regarding the structural relationships within the inner ear space because animal models of labyrinthitis or benign paroxysmal positional vertigo require accurate points for experimental manipulation (Inagaki et al., 2007; Katano et al., 2007). A recent report of a murine study regarding the effects of stem cells on the damaged cochlea reported fine manipulation in the extremely small labyrinth (Okano et al., 2008).…”

Section: Discussionmentioning

confidence: 99%

Three‐Dimensional Anatomy of the Temporal Bone in Normal Mice

Lee

Park

Kang

et al. 2009

Anat Histol Embryol

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This study was performed to determine the three-dimensional (3D) structure of the murine temporal bone and to provide a survey atlas of the temporal bone structures in mice. The temporal bones of adult BALB/c mice were examined and 3D high-resolution reconstructions of the temporal bone were obtained using a micro-CT system. Using the system described here, the bony labyrinth and membranous labyrinth could be investigated in a non-destructive manner. The turning rate of the cochlea was two (human rate: two and a half). The shapes of the superior and posterior semicircular canals were more flexed than those in humans. The malleus manubrium was directed anteriorly and was thin and fan-shaped like a Persian sword. The size of the incus relative to the malleus was smaller than that in the human ossicles. The 3D reconstruction of murine temporal bone described in this study provides anatomical information that will be useful in future studies using mouse model.

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Model experiments of BPPV using isolated utricle and posterior semicircular canal

Cited by 28 publications

References 9 publications

Residual Dizziness after Successful Repositioning Maneuver for Idiopathic Benign Paroxysmal Positional Vertigo: A Review

Residual Dizziness after Successful Repositioning Maneuver for Idiopathic Benign Paroxysmal Positional Vertigo: A Review

Comparative Study on the Roles of the Number of Accelerations and Rotation Angle in the Treatment Maneuvers for Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo

Three‐Dimensional Anatomy of the Temporal Bone in Normal Mice

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