Modeling Acute and Chronic Toxicity of Nonpolar Narcotic Chemicals and Mixtures toCeriodaphnia dubia

Niederlehner, B. R.; Cairns, John; Smith, Eric P.

doi:10.1006/eesa.1997.1621

Cited by 44 publications

(23 citation statements)

References 14 publications

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“…This is particularly true for acute toxicity of a large number of components at low concentrations or chronic toxicity of compounds in the environment below their individual LOECs (ECETOC, 2001;Escher and Hermens, 2002). For 20 of 24 mixtures containing similar and dissimilar chemicals, dose addition predicted toxicity within 95% confidence limits of actual toxicity observed (Niederlehner et at, 1998). A review of aquatic toxicity of 202 binary insecticide, herbicide and fungicide mixtures found that-92% were within the bounds of additivity (i.e., between 0.5 and 2.0 toxic equivalents when the expected toxicity from dose addition was 1.0).…”

Section: Risk Calculation Procedures For Component Dose Addition Apprmentioning

confidence: 99%

“…The effects are reversible, provided the membrane concentration fails to reach the internal effect threshold; this threshold is specific to species, size (surface:volume ratio), lipid content and other factors (Altenburger et al, 2003;Escher and Hermens, 2002). Most organic compounds have specific toxicity at higher concentrations but low levels can result in non-specific effects (Dyer et at., 2000;Niederlehner et at., 1998).…”

Section: Risk Calculation Procedures For Component Dose Addition Apprmentioning

confidence: 99%

“…Additivity occurs even when components are present below the individual chemical lowest observable effect concentrations (LOECs). Concentrations can be as low as 0.25% of an EC50 (effective concentration for 50% of the exposed organisms) (Escher and Hermens, 2002;Niederlehner et a!, 1998;Vighi and Calamari, 1996). Additivity was used to explain cumulative metals toxicity to striped bass in Chesapeake Bay; Al, Cd, Cr, Cu and Zn were present in the Bay below regulatory levels but dose additive predictions of toxicity correlated well with observed effects (Logan and Wilson, 1995).…”

Section: Risk Calculation Procedures For Component Dose Addition Apprmentioning

confidence: 99%

“…Dose addition is the most commonly used component method for predicting mixture toxicity (Niederlehner et a!, 1998). Toxicity of related chemicals or those having the same mode of action can be summed using additivity or dose addition (ECETOC, 2001;Escher and Hermens, 2002).…”

Section: Risk Calculation Procedures For Component Dose Addition Apprmentioning

confidence: 99%

“…For the main dose addition assumption to be upheld, chemicals are required to have similarly shaped curves. Sufficient dose-response data to build a curve is needed for input into effects models to predict impact (Niederlehner et al, 1998; U.S.…”

Section: Risk Calculation Procedures For Component Dose Addition Apprmentioning

confidence: 99%

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The Toxicology of Chemical Mixtures Risk Assessment for Human and Ecological Receptors

Sterner¹,

Robinson²,

Mattie³

et al. 2005

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REPORT DOCUMENTATION PAGE ublic reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the lata needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing ,is burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently alid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE (DD-MM-YYYY)2 I. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S)kir Force Materiel Command*** HEPB SUPPLEMENTARY NOTES ABSTRACT4ixtures of chemicals represent a concern in all areas of toxicology and a challenge to risk Issessors as most sites with environmental contamination, including Department of Defense sites, involve simultaneous or sequential exposures of multiple chemicals to human or ýcological receptors.A major concern with mixtures is that they may lead to outcomes (health effects) or increased toxicity (synergism) not expected from the risk 'haracterization of individual chemicals at the site.The focus of this literature review is :o examine the principles used to determine toxicity in chemical mixtures risk assessment for luman and ecological receptors at hazardous waste sites.This review provides an overview of 'urrent practices useful to a remedial project manager or risk assessor prior to their first ",hemical mixtures risk assessment. 5.SUBJECTTERMS

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Section: Risk Calculation Procedures For Component Dose Addition Apprmentioning

confidence: 99%

Section: Risk Calculation Procedures For Component Dose Addition Apprmentioning

confidence: 99%

Section: Risk Calculation Procedures For Component Dose Addition Apprmentioning

confidence: 99%

Section: Risk Calculation Procedures For Component Dose Addition Apprmentioning

confidence: 99%

Section: Risk Calculation Procedures For Component Dose Addition Apprmentioning

confidence: 99%

See 3 more Smart Citations

The Toxicology of Chemical Mixtures Risk Assessment for Human and Ecological Receptors

Sterner¹,

Robinson²,

Mattie³

et al. 2005

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Chronic toxicity of selected polycyclic aromatic hydrocarbons to algae and crustaceans using passive dosing

Bragin

Parkerton

Redman

et al. 2016

Enviro Toxic and Chemistry

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Because of the large number of possible aromatic hydrocarbon structures, predictive toxicity models are needed to support substance hazard and risk assessments. Calibration and evaluation of such models requires toxicity data with well-defined exposures. The present study has applied a passive dosing method to generate reliable chronic effects data for 8 polycyclic aromatic hydrocarbons (PAHs) on the green algae Pseudokirchneriella subcapitata and the crustacean Ceriodaphnia dubia. The observed toxicity of these substances on algal growth rate and neonate production were then compared with available literature toxicity data for these species, as well as target lipid model and chemical activity-based model predictions. The use of passive dosing provided well-controlled exposures that yielded more consistent data sets than attained by past literature studies. Results from the present study, which were designed to exclude the complicating influence of ultraviolet light, were found to be well described by both target lipid model and chemical activity effect models. The present study also found that the lack of chronic effects for high molecular weight PAHs was consistent with the limited chemical activity that could be achieved for these compounds in the aqueous test media. Findings from this analysis highlight that variability in past literature toxicity data for PAHs may be complicated by both poorly controlled exposures and photochemical processes that can modulate both exposure and toxicity. Environ Toxicol Chem 2016;35:2948-2957. © 2016 SETAC.

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Duration of life‐cycle toxicity tests with the ostracod Heterocypris incongruens

Hiki

Tobino

Nakajima

et al. 2017

Enviro Toxic and Chemistry

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An acute sediment toxicity test using the ostracod Heterocypris incongruens is user friendly and has high sensitivity; however, a life-cycle test using this species has not been developed. The most challenging problem when developing a life-cycle test is that the egg development time varies greatly and is sometimes too long (> 150 d) to monitor. It is desirable to shorten the duration of life-cycle toxicity tests including the observation period of egg development while preserving the ecological relevance of the net reproductive rate (R ), an endpoint in the life-cycle test. Therefore, in the present study, we suggest a practical test duration for R using population growth rate (λ) as a measure of ecological relevance. We collected a range of life history characteristics of the ostracod by combining data from the literature and experimental results, constructed population matrix models, and calculated λ for 20 life history patterns. The results showed that a longer test period (> 150 d) did not increase the correlation coefficients between R and λ. Rather, a shorter test duration resulted in R being highly correlated with λ. Our results suggest that a life-cycle toxicity test using the ostracod can provide an ecologically relevant toxicity endpoint, even if the test is abandoned after approximately 50 d and unhatched eggs remain. Environ Toxicol Chem 2017;36:3443-3449. © 2017 SETAC.

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Modeling Acute and Chronic Toxicity of Nonpolar Narcotic Chemicals and Mixtures toCeriodaphnia dubia

Cited by 44 publications

References 14 publications

The Toxicology of Chemical Mixtures Risk Assessment for Human and Ecological Receptors

The Toxicology of Chemical Mixtures Risk Assessment for Human and Ecological Receptors

Chronic toxicity of selected polycyclic aromatic hydrocarbons to algae and crustaceans using passive dosing

Duration of life‐cycle toxicity tests with the ostracod Heterocypris incongruens

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