Under the background of large-scale addition of new base stations in CDMA networks, co-PN-o ff set interferences and adjacent PN-offset interferences are much prone to happen. In this paper, the great significance of PN offset optimization are discussed, three existing methods are described, and a new automatically implemented strategy of PN offset optimization, which is also competent for reasonable PN offset choice of a new cell, is especially proposed. By the usage of practical examples and comparison of new scheme to old ones, it is proved that the scheme brought by the paper can achieve the goal of higher performance.