Slime Mould Algorithm (SMA) is a newly designed meat-heuristic search that mimics the nature of slime mould during the oscillation phase. This is demonstrated in a unique mathematical formulation that utilizes adjustable weights to influence the sequence of both negative and positive propagation waves to develop a method to link food supply with intensive exploration capacity and exploitation affinity. The study shows the usage of the SM algorithm to solve a non-convex and cost-effective Load Dispatch Problem (ELD) in an electric power system. The effectiveness of SMA is investigated for single area economic load dispatch on large-, medium-, and small-scale power systems, with 3-, 5-, 6-, 10-, 13-, 15-, 20-, 38-, and 40-unit test systems, and the results are substantiated by finding the difference between other well-known meta-heuristic algorithms. The SMA is more efficient than other standard, heuristic, and meta-heuristic search strategies in granting extremely ambitious outputs according to the comparison records.