Modeling dermal granulation tissue with the linear fibroblast-populated collagen matrix: A comparison with the round matrix model

Eichler, Markus; Carlson, Mark A.

doi:10.1016/j.jdermsci.2005.09.002

Cited by 32 publications

(22 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…When considering the healing phase of burns started on day 7 to 14 and the heavy fibroblast migration into the wound area after day 7, collagen density increased on days 7 to 14; these data confirm in vitro/in vivo findings on the healing phase a documented in previous studies. 25,26 Also, macroscopic images of the wounds treated with CFF were parallel to histopathological findings. Groups treated with CFF were completely healed on day 21, while the healing of other groups was still in progress ( Figure 4).…”

Section: E5mentioning

confidence: 98%

Chitosan film containing fucoidan as a wound dressing for dermal burn healing: Preparation and in vitro/in vivo evaluation

et al. 2007

View full text Add to dashboard Cite

The aim of this study was to develop chitosan film containing fucoidan and to investigate its suitability for the treatment of dermal burns on rabbits. Porous films, thickness between 29.7 and 269.0 μm, were obtained by the solvent dropping method. Water vapor permeability (3.3-16.6/0.1 g), the swelling (0.67-1.77 g/g), tensile strength (7.1-45.8 N), and bioadhesion (0.076-1.771 mJ/cm 2 ) of the films were determined. The thinnest films were obtained with the lowest chitosan concentration (P G .05). The water absorption capacity of the films sharply increased with the freeze-drying technique. The film having the thickness of 29.7 μm showed the highest amount of moisture permeability (16.6 g/0.1 g). Higher chitosan concentration significantly increased tensile strength of the films (P G .05). Using higher concentration of lactic acid made films more elastic and applicable, and these films were selected for in vivo studies. Seven adult male New Zealand white rabbits were used for the evaluation of the films on superficial dermal burns. Biopsy samples were taken at 7, 14, and 21 days after wounding, and each wound site was examined macroscopically and histopathologically. After 7 days treatment, fibroplasia and scar were observed on wounds treated with fucoidan-chitosan film. The best regenerated dermal papillary formation, best reepithelization, and the fastest closure of wounds were found in the fucoidan-chitosan film treatment group after 14 days compared with other treatment and control groups. It can be concluded that fucoidan-chitosan films might be a potential treatment system for dermal burns and that changing formulation variables can modulate the characterizations of the films.

show abstract

Section: E5mentioning

confidence: 98%

Chitosan film containing fucoidan as a wound dressing for dermal burn healing: Preparation and in vitro/in vivo evaluation

et al. 2007

View full text Add to dashboard Cite

show abstract

“…48 Approximately a week after wounding, contraction begins in the wound, as fibroblasts had differentiated into myofibroblasts. 55 When the actins in myofibroblasts contracts, the wound edges are pulled together. 55 Fibroblasts lay down collagen to reinforce the wound as the myofibroblasts contract.…”

Section: Discussionmentioning

confidence: 99%

“…55 When the actins in myofibroblasts contracts, the wound edges are pulled together. 55 Fibroblasts lay down collagen to reinforce the wound as the myofibroblasts contract. 48 The cellular metabolic rate was observed to have decreased both at the center and edge after the tenth day.…”

Section: Discussionmentioning

confidence: 99%

In vivowound healing diagnosis with second harmonic and fluorescence lifetime imaging

Deka

Kao

2012

J. Biomed. Opt

View full text Add to dashboard Cite

Abstract. Skin wounds heal when a series of cell lineages are triggered, followed by collagen deposition, to reconstruct damaged tissues. This study evaluates the regeneration of collagen and change in cellular metabolic rate in vivo during wound healing in rats, with second harmonic generation (SHG) and fluorescence lifetime imaging microscopy respectively. The metabolic rate of cells is reflected through the lifetime of the autofluorescence from the co-enzyme protein, reduced nicotinamide adenine dinucleotide, due to its change in the relative concentration of bound and free forms. A higher than normal cellular metabolic rate is observed during the first week of healing, which decreases gradually after eight days of wound formation. SHG signal intensity change indicates the net degradation of collagen during the inflammatory phase, and net regeneration begins on day five. Eventually, the quantity of collagen increases gradually to form a scar tissue as the final product. Importantly, this work demonstrates the feasibility of an in vivo imaging approach for a normal wound on rat skin, which has the potential to supplement the noninvasive clinical diagnosis of wounds.

show abstract

“…Eichler and Carlson [12] suggest, however, that dermal granulous tissue exhibits properties similar to fibroblast-populated collagen gels. Such gels can also be modeled as neo-Hookean over moderate ranges of finite deformation, hence

{\overset{W}{true}}^{g} = c^{g} (I_{c}^{g} - 3),

where c g ~ 0.2 kPa according to [39] and granoulos tissue pre-stretch is

G_{h}^{g} = 1.05

.…”

Section: Theoretical Frameworkmentioning

confidence: 99%

A mathematical model of evolving mechanical properties of intraluminal thrombus

Karšaj

Humphrey

2009

Biorheology: The Official Journal of the International Society

View full text Add to dashboard Cite

Quantifying mechanical properties of blood clots is fundamental to understanding many aspects of cardiovascular disease and its treatment. Nevertheless, there has been little attention to quantifying the evolving composition, structure, and properties when a clot transforms from an initial fibrin-based mesh to a predominantly collagenous mass. Although more data are needed to formulate a complete mathematical model of the evolution of clot properties, we propose a general constrained mixture model based on diverse data available from in vitro tests on fibrinogenesis, the stiffness of fibrin gels, and fibrinolysis as well as histological and mechanical data from clots retrieved from patients at surgery or autopsy. In particular, albeit resulting from complex kinetics involving many clotting factors, we show that the rapid (minutes) in vitro production of fibrin from fibrinogen can be modeled well by an Avrami-type relation and similarly that the fast (tens of minutes) in vitro degradation of fibrin in response to different concentrations of plasmin can be captured via a single “master function” parameterized by appropriate half-times that can be inferred from laboratory or clinical data. Accounting simultaneously for the production and removal of fibrin as well as chemo-mechano-stimulated production of fibrillar collagens yields predictions of changing mass fractions and bulk mechanical properties that correspond well to experimentally available data. Constrained mixture models thus hold considerable promise for modeling the biomechanics of clot evolution and can guide the design and interpretation of needed experiments and stress analyses.

show abstract

Modeling dermal granulation tissue with the linear fibroblast-populated collagen matrix: A comparison with the round matrix model

Cited by 32 publications

References 34 publications

Chitosan film containing fucoidan as a wound dressing for dermal burn healing: Preparation and in vitro/in vivo evaluation

Chitosan film containing fucoidan as a wound dressing for dermal burn healing: Preparation and in vitro/in vivo evaluation

In vivowound healing diagnosis with second harmonic and fluorescence lifetime imaging

A mathematical model of evolving mechanical properties of intraluminal thrombus

Contact Info

Product

Resources

About