Modeling Human Disease and Development in Zebrafish

Chitramuthu, Babykumari P.

doi:10.4172/2161-0436.1000e108

Cited by 10 publications

(5 citation statements)

References 48 publications

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“…Zebrafish can be used as a model for human disease and to research underlying mechanisms because the cloning of mutant genes tested for certain characteristics in zebrafish shares parallels with human disease. The first human illness discovered in zebrafish was a blood condition caused by a mutation in the ALAS2 gene, which specifically affects hemoglobin manufacturing [103].…”

Section: Human Disease and Zebrafishmentioning

confidence: 99%

Zebrafish (Danio rerio) Evaluation as an Alternative Model for Biological Research

2023

IJGHC

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The quiet sentinels that keep watch on the world's environmental health are animals as model organisms. These non-human animal species can be utilized to comprehend particular biological processes and gather data that can shed light on how other creatures function. One of the finest leading models for studying developmental biology, cardiovascular studies, Dermatological studies, Cancer, Toxicity, Drug discovery, Xenotransplantation, and Molecular genetics among model organisms is the zebrafish (Danio rerio). The zebrafish is also being used more and more as a genetic model organism for aquaculture species, in toxicogenomic research, and to create illness models in the fish that may be used in human biomedicine. Due to its simple care requirements, ease of reproduction, and translucent body during early growth, this little fish serves as a flexible model organism for several scientific disciplines.

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Section: Human Disease and Zebrafishmentioning

confidence: 99%

Zebrafish (Danio rerio) Evaluation as an Alternative Model for Biological Research

2023

IJGHC

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“…Zebrafish ( Danio rerio ) have played an important role in accelerating our knowledge in embryonic development, regeneration, gene expression, transgenesis, environmental monitoring, drug discovery, cardiovascular diseases, immunology, infectious diseases, RNA splicing, stem cell biology and a host of other areas of importance to medical science [ 33 , 43 , 44 , 45 , 46 ]. At least 20% of the zebrafish’s duplicated gene pairs have been retained from this WGD [ 47 , 48 , 49 , 50 ].…”

Section: The Importance Of Fish Cytogenomic Research Demonstrated mentioning

confidence: 99%

Vertebrate Genome Evolution in the Light of Fish Cytogenomics and rDNAomics

Symonová

Howell

2018

Genes

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To understand the cytogenomic evolution of vertebrates, we must first unravel the complex genomes of fishes, which were the first vertebrates to evolve and were ancestors to all other vertebrates. We must not forget the immense time span during which the fish genomes had to evolve. Fish cytogenomics is endowed with unique features which offer irreplaceable insights into the evolution of the vertebrate genome. Due to the general DNA base compositional homogeneity of fish genomes, fish cytogenomics is largely based on mapping DNA repeats that still represent serious obstacles in genome sequencing and assembling, even in model species. Localization of repeats on chromosomes of hundreds of fish species and populations originating from diversified environments have revealed the biological importance of this genomic fraction. Ribosomal genes (rDNA) belong to the most informative repeats and in fish, they are subject to a more relaxed regulation than in higher vertebrates. This can result in formation of a literal ‘rDNAome’ consisting of more than 20,000 copies with their high proportion employed in extra-coding functions. Because rDNA has high rates of transcription and recombination, it contributes to genome diversification and can form reproductive barrier. Our overall knowledge of fish cytogenomics grows rapidly by a continuously increasing number of fish genomes sequenced and by use of novel sequencing methods improving genome assembly. The recently revealed exceptional compositional heterogeneity in an ancient fish lineage (gars) sheds new light on the compositional genome evolution in vertebrates generally. We highlight the power of synergy of cytogenetics and genomics in fish cytogenomics, its potential to understand the complexity of genome evolution in vertebrates, which is also linked to clinical applications and the chromosomal backgrounds of speciation. We also summarize the current knowledge on fish cytogenomics and outline its main future avenues.

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“…Beberapa hal yang dapat dijadikan pertimbangan untuk penggunaan zebrafish dalam bidang genetika ialah transparensi, produktivitas, dan kemudahannya dalam pencitraan (imaging). Pendekatan secara genetik dapat dilakukan untuk mendapatkan fenotip zebrafish yang baru dan identifikasi gen-gen baru yang menarik sebagai kandidat yang potensial untuk mencari relevansinya terhadap fenotip yang bertanggung jawab terhadap penyakit-penyakit pada manusia [82][83][84][85][86]. Beberapa penyakit genetika yang dapat diaplikasikan pada model zebrafish antara lain dilated cardiomyopathy, penyakit ginjal polisistik, duchenne muscular dystrophy, dan gangguan kongenital glikosilasi [87][88][89][90][91].…”

Section: Zebrafish Untuk Model Penyakit Genetikaunclassified

Aplikasi Zebrafish (Danio rerio) pada Beberapa Model Penyakit Eksperimental

Yuniarto

Sukandar

Fidrianny

et al. 2017

MPI

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Zebrafish (Danio rerio) merupakan jenis ikan tropis berukuran kecil yang banyak ditemukandi negara India dan Asia Selatan. Hingga saat ini, zebrafish telah digunakan sebagai organismemodel untuk pengembangan berbagai model penyakit, studi toksikologi, studi neurobiologi,gangguan-gangguan metabolisme, dan pengembangan genetika. Beberapa keunggulan dari penggunaanzebrafish antara lain mekanisme adaptasi terhadap lingkungan, naluri yang cukup bervariasi,pola sirkadian, dan berbagai macam mekanisme adaptasi lainnya. Secara genetika, zebrafishjuga memiliki persamaan gen yang menyerupai manusia. Persamaan gen ini merupakan prosesevolusi yang terjadi selama ratusan juta tahun yang lalu. Sebagai tambahan, zebrafish juga memilikipersamaan-persamaan lainnya dengan manusia antara lain yaitu pada sistem saluran pencernaan,jaringan adiposa viseral, sistem otot rangka, dan sistem organ lainnya. Persamaan gen, sistemsaluran pencernaan, jaringan adiposa viseral, sistem otot rangka, dan sistem organ lainnya menjadikanlandasan utama untuk pengembangan dan eksplorasi berbagai macam model penyakit padamanusia. Beberapa model yang dapat diaplikasikan pada model zebrafish antara lain model obesitas,diabetes mellitus, gangguan jantung atau kardiovaskular, gangguan ginjal, gangguan lipid, penyakitperlemakan hati, dan beberapa model lainnya.

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Modeling Human Disease and Development in Zebrafish

Cited by 10 publications

References 48 publications

Zebrafish (Danio rerio) Evaluation as an Alternative Model for Biological Research

Zebrafish (Danio rerio) Evaluation as an Alternative Model for Biological Research

Vertebrate Genome Evolution in the Light of Fish Cytogenomics and rDNAomics

Aplikasi Zebrafish (Danio rerio) pada Beberapa Model Penyakit Eksperimental

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