Modeling multispecies biofilms including new bacterial species invasion

D’Acunto, Berardino; Frunzo, Luigi; Klapper, Isaac; Mattei, Maria Rosaria

doi:10.1016/j.mbs.2014.10.009

Cited by 50 publications

(42 citation statements)

References 17 publications

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“…conversion between active and inactive material), diffusive or other forms of mobility, etc. [15,16,27], as well as the possibility for different material types to move with different velocities [13,25,38]. Upon summing equations (2), we obtain the volume conservation constraint…”

Section: Biofilm Modelmentioning

confidence: 99%

“…Biomass production results in pressure-driven expansion over long times, see (22), which causes the biofilm to gradually expand. To complete the model (biofilm plus metabolism), choice of a metabolic flux vector v satisfying Sv = 0, with S given in (15), is required. This amounts to fixing values of the flux amplitudes β 1 , β 2 , β 3 , which are arbitrary up to the requirement that all constraints be satisfied.…”

Section: Exchange Fluxes and The Biofilm Modelmentioning

confidence: 99%

“…Hooked arrows indicate biomass production. Stoichiometric coefficient are given in(15). (Right) Elementary flux modes for the metabolic model on the left.…”

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confidence: 99%

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Flux-Balance Based Modeling of Biofilm Communities

Parker

Carlson

et al. 2018

Preprint

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Models of microbial community dynamics generally rely on a sub-scale model for microbial metabolisms. In systems such as distributed multispecies communities like biofilms, where it is not reasonable to simplify to a small number of limiting substrates, tracking the large number of active metabolites likely requires measurement or estimation of large numbers of kinetic and regulatory parameters. Alternatively, a largely kinetics-free methodology is proposed combining cellular level constrained, steady state metabolic flux analysis with macro scale microbial community models. The methodology easily allows coupling of macroscale information, including measurement data, with cell-scale metabolism. Illustrative examples are included.

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Section: Biofilm Modelmentioning

confidence: 99%

Section: Exchange Fluxes and The Biofilm Modelmentioning

confidence: 99%

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Flux-Balance Based Modeling of Biofilm Communities

Parker

Carlson

et al. 2018

Preprint

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“…9 In the environment and even on the abiotic surfaces, it is very common to find microbial biofilms with other commensal species, which are, therefore, called biofilm multispecies. 10 Bacteria and fungi are both capable of forming biofilms on surfaces, but certain factors involved during the course of their formation differ from each other.…”

Section: Introductionmentioning

confidence: 99%

“…In a recent case, D'Acunto et al 10 identified C. parapsilosis to be responsible for generalized IC in two neonates. The authors reported the use of drugs, fluconazole and amphotericin B, for control of the infection, but with no success.…”

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confidence: 99%

Nanotechnology-based drug delivery systems for control of microbial biofilms: a review

Ramos¹,

Silva²,

Spósito³

et al. 2018

IJN

220

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Since the dawn of civilization, it has been understood that pathogenic microorganisms cause infectious conditions in humans, which at times, may prove fatal. Among the different virulent properties of microorganisms is their ability to form biofilms, which has been directly related to the development of chronic infections with increased disease severity. A problem in the elimination of such complex structures (biofilms) is resistance to the drugs that are currently used in clinical practice, and therefore, it becomes imperative to search for new compounds that have anti-biofilm activity. In this context, nanotechnology provides secure platforms for targeted delivery of drugs to treat numerous microbial infections that are caused by biofilms. Among the many applications of such nanotechnology-based drug delivery systems is their ability to enhance the bioactive potential of therapeutic agents. The present study reports the use of important nanoparticles, such as liposomes, microemulsions, cyclodextrins, solid lipid nanoparticles, polymeric nanoparticles, and metallic nanoparticles, in controlling microbial biofilms by targeted drug delivery. Such utilization of these nanosystems has led to a better understanding of their applications and their role in combating biofilms.

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