Modeling the Effect of Surface Modification of Gold Nanoparticles Irradiated with 60Co on the Secondary Рarticles Emission Spectrum

Belousov, Alexey V.; Морозов, В. Н.; Krusanov, G. A.; Колыванова, М. А.; Chernyaev, A. P.; Shtil, Alexander А.

doi:10.1134/s1028335818030059

Cited by 7 publications

(9 citation statements)

References 11 publications

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“…This process may be facilitated by electron/hole scavenger compounds such as ascorbic acid conjugated to or adsorbed at the NP surface. [205,206] If such scavengers are not provided, then the NPs undergo chemical degradation or, for example, may chemically transform the adsorbed ligands, leading to NP aggregation. [205] Close alignment of the conduction band and/or valence band edges with the reduction and/or oxidation potentials is desirable for efficient reduction and/or oxidation.…”

Section: Charge Transfer Photo-and Radiocatalysis-redox Reactionsmentioning

confidence: 99%

“…[205,206] If such scavengers are not provided, then the NPs undergo chemical degradation or, for example, may chemically transform the adsorbed ligands, leading to NP aggregation. [205] Close alignment of the conduction band and/or valence band edges with the reduction and/or oxidation potentials is desirable for efficient reduction and/or oxidation. [202,207] It should be noted, however, that these considerations do not impact the reaction rates, which are determined by activation energies and concentrations.…”

Section: Charge Transfer Photo-and Radiocatalysis-redox Reactionsmentioning

confidence: 99%

“…An important prerequisite for this is long electron-hole pair lifetime, so that it is beneficial to reduce the electron-hole recombination rate, for example, by facilitating the formation of triplet exciton states. [205]…”

Section: Heterojunctions and Carrier Storage In Charge Transfer Photomentioning

confidence: 99%

“…[226] Similar effects have been reported for the generation of hydroxyl radicals during radiolysis of water in the presence of AuNPs. [99] Another example of the effect of NP surface coating on ROS generation is decreased emission rate of electrons from PEG-coated AuNPs with increasing PEG layer thickness, as well as altered secondary electron energy spectrum, [205] both of which impact the ROS yield.…”

Section: Effects Of Surface Functionalization and Coatings On Ros Genmentioning

confidence: 99%

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Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

et al. 2020

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Engineered nanomaterials that produce reactive oxygen species on exposure to X‐ and gamma‐rays used in radiation therapy offer promise of novel cancer treatment strategies. Similar to photodynamic therapy but suitable for large and deep tumors, this new approach where nanomaterials acting as sensitizing agents are combined with clinical radiation can be effective at well‐tolerated low radiation doses. Suitably engineered nanomaterials can enhance cancer radiotherapy by increasing the tumor selectivity and decreasing side effects. Additionally, the nanomaterial platform offers therapeutically valuable functionalities, including molecular targeting, drug/gene delivery, and adaptive responses to trigger drug release. The potential of such nanomaterials to be combined with radiotherapy is widely recognized. In order for further breakthroughs to be made, and to facilitate clinical translation, the applicable principles and fundamentals should be articulated. This review focuses on mechanisms underpinning rational nanomaterial design to enhance radiation therapy, the understanding of which will enable novel ways to optimize its therapeutic efficacy. A roadmap for designing nanomaterials with optimized anticancer performance is also shown and the potential clinical significance and future translation are discussed.

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Section: Charge Transfer Photo-and Radiocatalysis-redox Reactionsmentioning

confidence: 99%

Section: Charge Transfer Photo-and Radiocatalysis-redox Reactionsmentioning

confidence: 99%

Section: Heterojunctions and Carrier Storage In Charge Transfer Photomentioning

confidence: 99%

Section: Effects Of Surface Functionalization and Coatings On Ros Genmentioning

confidence: 99%

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Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

et al. 2020

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“…However, nano-radiosensitizers are rather delicate systems. Even minor changes in their characteristics may affect their interaction with cells [18,19] as well as the physicochemical aspects of radiosensitization [20][21][22][23][24][25][26] ultimately leading to significant differences in the magnitude of the effect of NPs [27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Radiosensitization by Gold Nanoparticles: Impact of the Size, Dose Rate, and Photon Energy

et al. 2020

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Gold nanoparticles (GNPs) emerged as promising antitumor radiosensitizers. However, the complex dependence of GNPs radiosensitization on the irradiation conditions remains unclear. In the present study, we investigated the impacts of the dose rate and photon energy on damage of the pBR322 plasmid DNA exposed to X-rays in the presence of 12 nm, 15 nm, 21 nm, and 26 nm GNPs. The greatest radiosensitization was observed for 26 nm GNPs. The sensitizer enhancement ratio (SER) 2.74 ± 0.61 was observed at 200 kVp with 2.4 mg/mL GNPs. Reduction of X-ray tube voltage to 150 and 100 kVp led to a smaller effect. We demonstrate for the first time that the change of the dose rate differentially influences on radiosensitization by GNPs of various sizes. For 12 nm, an increase in the dose rate from 0.2 to 2.1 Gy/min led to a ~1.13-fold increase in radiosensitization. No differences in the effect of 15 nm GNPs was found within the 0.85–2.1 Gy/min range. For 21 nm and 26 nm GNPs, an enhanced radiosensitization was observed along with the decreased dose rate from 2.1 to 0.2 Gy/min. Thus, GNPs are an effective tool for increasing the efficacy of orthovoltage X-ray exposure. However, careful selection of irradiation conditions is a key prerequisite for optimal radiosensitization efficacy.

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Hafnium Oxide as a Nanoradiosensitizer under X-ray Irradiation of Aqueous Organic Systems: A Model Study Using the Spin-Trapping Technique and Monte Carlo Simulations

et al. 2019

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The development of the physicochemical basis for applications of nanoradiosensitizers for targeted treatment of tumors is one of the crucial issues of modern radiotherapy. Ceramic nanoparticles (NPs) composed of heavy metal oxides are considered as prospective sensitizers, particularly for X-ray treatment. This study reports a novel approach for experimental simulations of the radiosensitizing effect of NPs in biomimetic systems based on the quantification of radicals produced from organic components in concentrated aqueous organic solutions using the spin-trapping technique with electron paramagnetic resonance detection. This approach was first applied to X-ray irradiation (45 kVp) of aqueous methanol solutions systems containing different concentrations of hafnium oxide nanoparticles with an average diameter of ca. 84 nm (up to 1.8 wp). It was found that the amount of radicals produced from methanol at the same exposition time increased linearly with the increasing content of HfO 2 NPs. The effect can be reasonably explained by the physical enhancement mechanism associated with efficient transfer of absorbed energy from the NPs to aqueous organic medium. The Monte Carlo simulations were applied to calculate the absorbed dose in the studied systems as a function of NP concentration. The experimental enhancement factor in the formation of radicals (0.71 wp −1 ) was found to be slightly lower than the calculated coefficient of the absorbed dose enhancement (0.80 wp −1 ), which can be explained by partial self-absorption of generated secondary electrons inside rather bulky HfO 2 nanoparticles. The proposed model approach may provide a rational ground for comparative studies of different nanoradiosensitizers and the optimization of the NP size, photon energy, and other factors.

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Modeling the Effect of Surface Modification of Gold Nanoparticles Irradiated with 60Co on the Secondary Рarticles Emission Spectrum

Cited by 7 publications

References 11 publications

Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

Radiosensitization by Gold Nanoparticles: Impact of the Size, Dose Rate, and Photon Energy

Hafnium Oxide as a Nanoradiosensitizer under X-ray Irradiation of Aqueous Organic Systems: A Model Study Using the Spin-Trapping Technique and Monte Carlo Simulations

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