Modeling the mixing behavior of a novel fluidized extracorporeal immunoadsorber

Immunoadsorption model for a novel fluidized‐bed blood detoxification device

“…We designed a multicompartment Taylor-Couette flow hemofilter to remove toxins from a patient's bloodstream via immunoadsorption. The first immunoadsorption application was to remove the amyloid-associated protein ␤ -micro-2 C 0 mgrL V 6.6, 6.3, 6.1, 5.9 mL g el BC,i ‡, § ts0 C 0 mgrL 5.7, 5.5, 5.3, 5.1 Grovender et al 2001 . § The mixing behavior was re-characterized through similar RTD studies using a 36% glycerol-in-water solution at 20ЊC to better account for Ž the viscosity and density of whole blood Wolf et al, 1984;Fournier, .…”

“…is constant, but each tank has its own unique volume V BC,i Ž . Grovender et al, 2001 . Equations 10᎐14 represent a mass balance of ␤ m within the blood compartment, taking into 2 account hemofiltration into the active plasma compartment…”

“…Ž . previously described Grovender et al, 2001 ; 5 the size of the gel beads can be well represented by the volume-average radius R.…”

“…. Grovender et al, 2001 . Herein, the equilibrium behavior of immunoadsorptive gel beads is characterized using the Langmuir adsorption isotherm and confocal microscopy.…”

Dextran Aldehyde in Biocatalysis: More Than a Mere Immobilization System

“…Furthermore, enzyme solubility may be a problem in some applications. Clearly, this may not be the case when using enzymes in biomedicine (although there are some circumstances where its immobilization is also required, e.g., in extracorporeal dispositives [43][44][45][46]), but in most other applications enzyme immobilization is required, mainly when the enzyme is going to be reused (as happens in industrial biocatalysis). In these cases, it must be separated from the reaction media, or it should be fixed on the tip of a transducer to maximize the signal (e.g., in biosensors) [47][48][49][50][51][52][53][54][55][56].…”