Modeling the Safety Benefits of Converting Signalized Y Shaped Junctions to Signalized T Junctions

Lü, Weijie; Lu, Linjun; Bi, Hezheng; Lü, Jian

doi:10.1061/9780784413869.012

Cited by 30 publications

(31 citation statements)

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“…In the candidate region, short tandem repeat (STR) analysis revealed negative findings, while the variable number of tandem repeats (VNTR) analysis showed reads with an abnormal 39 9 99-neucleotide sequence in exon 3 of PLIN4 in F1-III3, and the repeat was 29 times that of the control. Consistent with the previous study, 7 our LRS data indicated that the VNTR in PLIN4 was composed of consecutive repetitive DNA with hypervariable motif composition (Fig. S1).…”

Section: Genetic Analysissupporting

confidence: 92%

Subsarcolemmal and cytoplasmic p62 positivity and rimmed vacuoles are distinctive for PLIN4‐myopathy

Wang

Zhang

et al. 2022

Ann Clin Transl Neurol

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PLIN4-myopathy is a recently identified autosomal dominant muscular disorder caused by the coding 99 bp repeat expansion in PLIN4, presenting with distal or proximal weakness. Here, we report one family and one sporadic case of adult-onset PLIN4-associated limb-girdle weakness, whose diagnoses were achieved by a comprehensive genetic analysis workup. We provided additional evidence that the combination of subsarcolemmal/cytoplasmic ubiquitin/p62 positive deposits and rimmed vacuoles could serve as a strong indicator of PLIN4-myopathy. Moreover, we found novel myopathological features that were ultrastructural subsarcolemmal filamentous materials and membranebound granulofilamentous inclusions formed by the co-deposition of disrupted lipid droplets and p62 protein aggregates.

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Section: Genetic Analysissupporting

confidence: 92%

Subsarcolemmal and cytoplasmic p62 positivity and rimmed vacuoles are distinctive for PLIN4‐myopathy

Wang

Zhang

et al. 2022

Ann Clin Transl Neurol

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“…Based on this point, some new 2D materials, which are composed of heavy elements [10][11][12][13][14][15][16] , have been predicted as the candidates for large gap QSHIs. However, the observations of QSHE are still challengeable experimentally.…”

mentioning

confidence: 99%

Large-gap quantum spin Hall state in functionalized dumbbell stanene

Wang

et al. 2016

Applied Physics Letters

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Phys. Rev. B, 90, 121408 (2014)]. However, the small bulk-gap limits its possible applications at room temperature. Based on first-principles calculations, we predict that its band gap can be enhanced to 148 meV under methyl-functionalization, which can be further tuned by applying lattice strain. The QSHE is confirmed by s-p x,y band inversion, topological invariant Z 2 = 1, and helical gapless edge within bulk band gap.Notably, the characteristic properties of edge states, such as the large Fermi velocity and Dirac cone, can be modulated by edge modification. The effects of substrates on topological properties are explored when it is grown on various substrates, like SiC, h-BN, and Bi 2 Te 3 sheets. These findings provide significant guidance for future fabrication and realistic applications of QSHE based on stanene in spintronics.

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“…All functionals presented the same spin order and similar gaps, which indicates that the choice of the B3LYP functional is reasonable. Minimum-energy crossing points (MECPs) were located using the sobMECP program, which uses methods developed by Harvey and Robb. , The oxidation state of iodine in 1 1 LBHB was determined using the Multiwfn program, in which the localized orbital bonding analysis (LOBA) method of Head-Gordon and co-workers is implemented . Energy values presented in the text were calculated at the UB3LYP/B2//B1 level.…”

Section: Computational Methodologymentioning

confidence: 99%

Brønsted Acids Promote Olefin Oxidations by Bioinspired Nonheme Co^III(PhIO)(OH) Complexes: A Role for Low-Barrier Hydrogen Bonds

et al. 2023

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Introduction of Brønsted acids into biomimetic nonheme reactions promotes the oxidative ability of metal−oxygen complexes significantly. However, the molecular machinery of the promoted effects is missing. Herein, a comprehensive investigation of styrene oxidation by a cobalt(III)−iodosylbenzene complex, [(TQA)-Co III (OIPh)(OH)] 2+ (1, TQA = tris(2-quinolylmethyl)amine), in the presence and absence of triflic acid (HOTf) was performed using density functional theory calculations. Results revealed for the first time that there is a low-barrier hydrogen bond (LBHB) between HOTf and the hydroxyl ligand of 1, which forms two valenceresonance structures [(TQA)Co III (OIPh)(HO − --HOTf)] 2+ (1 LBHB ) and [(TQA)Co III (OIPh)(H 2 O--OTf − )] 2+ (1′ LBHB ). Due to the oxo-wall, these complexes (1 LBHB and 1′ LBHB ) cannot convert to high-valent cobalt−oxyl species. Instead, styrene oxidation by these oxidants (1 LBHB and 1′ LBHB ) shows novel spin-state selectivity, i.e., on the ground closed-shell singlet state, styrene is oxidized to an epoxide, whereas on the excited triplet and quintet states, an aldehyde product, phenylacetaldehyde, is formed. The preferred pathway is styrene oxidation by 1′ LBHB , which is initiated by a rate-limiting bond-formation-coupled electron transfer process with an energy barrier of 12.2 kcal mol −1 . The nascent PhIO-styrene-radical-cation intermediate undergoes an intramolecular rearrangement to produce an aldehyde. The halogen bond between the OH − /H 2 O ligand and the iodine of PhIO modulates the activity of the cobalt−iodosylarene complexes 1 LBHB and 1′ LBHB . These new mechanistic findings enrich our knowledge of nonheme chemistry and hypervalent iodine chemistry and will play a positive role in the rational design of new catalysts.

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Modeling the Safety Benefits of Converting Signalized Y Shaped Junctions to Signalized T Junctions

Cited by 30 publications

References 0 publications

Subsarcolemmal and cytoplasmic p62 positivity and rimmed vacuoles are distinctive for PLIN4‐myopathy

Subsarcolemmal and cytoplasmic p62 positivity and rimmed vacuoles are distinctive for PLIN4‐myopathy

Large-gap quantum spin Hall state in functionalized dumbbell stanene

Brønsted Acids Promote Olefin Oxidations by Bioinspired Nonheme Co^III(PhIO)(OH) Complexes: A Role for Low-Barrier Hydrogen Bonds

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Modeling the Safety Benefits of Converting Signalized Y Shaped Junctions to Signalized T Junctions

Cited by 30 publications

References 0 publications

Subsarcolemmal and cytoplasmic p62 positivity and rimmed vacuoles are distinctive for PLIN4‐myopathy

Subsarcolemmal and cytoplasmic p62 positivity and rimmed vacuoles are distinctive for PLIN4‐myopathy

Large-gap quantum spin Hall state in functionalized dumbbell stanene

Brønsted Acids Promote Olefin Oxidations by Bioinspired Nonheme CoIII(PhIO)(OH) Complexes: A Role for Low-Barrier Hydrogen Bonds

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About

Brønsted Acids Promote Olefin Oxidations by Bioinspired Nonheme Co^III(PhIO)(OH) Complexes: A Role for Low-Barrier Hydrogen Bonds