A 3-D unstructured-grid hydrodynamic model for the northern Gulf of Mexico was developed, with a hybrid s-z vertical grid and high-resolution horizontal grid for the main estuarine systems along the Texas-Louisiana coast. This model, based on the Semi-implicit Cross-scale Hydroscience Integrated System Model (SCHISM), is driven by the observed river discharge, reanalysis atmospheric forcing, and open boundary conditions from global HYCOM output. The model reproduces the temporal and spatial variation of observed water level, salinity, temperature, and current velocity in Galveston Bay and on the shelf. The validated model was applied to examine the remote influence of neighboring large rivers, specifically the Mississippi-Atchafalaya River (MAR) system, on salinity, stratification, vertical mixing, and longshore transport along the Texas coast. Numerical experiments reveal that the MAR discharge could significantly decrease the salinity and change the stratification and vertical mixing on the inner Texas shelf. It would take about 25 and 50 d for the MAR discharge to reach the mouth of Galveston Bay and Port Aransas, respectively. The influence of the MAR discharge is sensitive to the wind field. Winter wind constrains the MAR freshwater to form a narrow lower-salinity band against the shore from the Mississippi Delta all the way to the southwestern Texas coast, while summer wind reduces the downcoast longshore transport significantly, weakening the influence of the MAR discharge on surface salinity along Texas coast. However, summer wind causes a much stronger stratification on the Texas shelf, leading to a weaker vertical mixing. The decrease in salinity of up to 10 psu at the mouth of Galveston Bay due to the MAR discharge results in a decrease in horizontal density gradient, a decrease in the salt flux, and a weakened estuarine circulation and estuarine-ocean exchange. We highlight the flexibility of the model and its capability to simulate not only estuarine dynamics and shelf-wide transport, but also the interactions between them.