Modelling Amoebic Brain Infection Caused byBalamuthia mandrillarisUsing a Human Cerebral Organoid
Nongnat Tongkrajang,
Phorntida Kobpornchai,
Pratima Dubey
et al.
Abstract:The lack of disease models adequately resembling human tissue has hindered our understanding of amoebic brain infection. Three-dimensional structured organoids provide a microenvironment similar to human tissue. This study demonstrates the use of cerebral organoids to model a rare brain infection caused by the highly lethal amoebaBalamuthia mandrillaris. Cerebral organoids were generated from human pluripotent stem cells and infected with clinically isolatedB. mandrillaristrophozoites. Histological examination… Show more
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