Modelling benzo(a)pyrene concentrations for different meteorological conditions – Analysis of lung cancer cases and associated economic costs

Porwisiak, Paweł; Werner, Małgorzata; Kryza, Maciej; Vieno, Massimo; Holland, Mike; ApSimon, Helen; Drzeniecka-Osiadacz, Anetta; Skotak, Krzysztof; Gawuć, Lech; Szymankiewicz, Karol

doi:10.1016/j.envint.2023.107863

Cited by 8 publications

(2 citation statements)

References 45 publications

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“…The study employed a mouse model induced with benzo( a )pyrene compounds (BAP) to assess further the therapeutic effectiveness of developing cancer. BAP, a polycyclic aromatic hydrocarbon (PAH), is known for its exceptionally high carcinogenic potential. , This propensity arises from the metabolic conversion of PAH compounds in the body into diol epoxides, , which subsequently bind to DNA and initiate the carcinogenic process. The results demonstrated that the B-CDs/Naproxen group exhibited a significant decrease in malignancy diameter throughout the study, while the control group showed a notable increase in cancer size volume.…”

Section: Discussionmentioning

confidence: 99%

Strategic Assessment of Boron-Enriched Carbon Dots/Naproxen: Diagnostic, Toxicity, and In Vivo Therapeutic Evaluation

Wibrianto,

Putri,

Nisa

et al. 2024

Mol. Pharmaceutics

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Cancer is a significant global public health concern, ranking as the leading cause of mortality worldwide. This study thoroughly explores boron-doped carbon dots (B-CDs) through a simple/rapid microwave-assisted approach and their versatile applications in cancer therapy. The result was highly uniform particles with an average diameter of approximately 4 nm. B-CDs exhibited notable properties, including strong fluorescence with a quantum yield of 33%. Colloid stability tests revealed their robustness within a pH range of 6−12, NaCl concentrations up to 0.5 M, and temperatures ranging from 30 to 60 °C. The study also delved into the kinetics of naproxen release from B-CDs as a drug delivery system. The loading efficacy of naproxen exceeded 55.56%. Under varying pH conditions, the release of naproxen from B-CDs conformed to the Peppas−Sahlin model, demonstrating the potential of Naproxen-loaded CDs for cancer drug delivery. In vitro cytotoxicity assessments, conducted using the CCK-8 Assay and flow cytometry, consistently indicated low toxicity with average cell viability exceeding 80%. An in vivo toxicity test on female mice administered 20 mg/kg of B-CDs for 31 days revealed reversible histological changes in the liver and kidneys, while the pancreas remained unaffected. Importantly, B-CDs did not impact the mice's physical behavior, body weight, or survival. In vivo experiments targeting benzo(a)pyrene-induced fibrosarcoma demonstrated the efficacy of B-CDs as naproxen carriers in the treatment of cancer. This in vivo study provides a thorough comprehension of B-CDs synthesis and toxicity and their potential applications in cancer therapy and drug delivery systems.

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Section: Discussionmentioning

confidence: 99%

Strategic Assessment of Boron-Enriched Carbon Dots/Naproxen: Diagnostic, Toxicity, and In Vivo Therapeutic Evaluation

Wibrianto,

Putri,

Nisa

et al. 2024

Mol. Pharmaceutics

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“…Moreover, we have also included data for B(a)P, for which an association with the clinical course of COVID‐19 was only a subject of a few previous investigations during the pandemic 12,44 . Although the pandemic waves included in the present study, dominated by Delta and Omicron SARS‐CoV‐2 variants, encompassed different periods of the year, each of them also included months characterized by increased emission of PM and B(a)P in Poland, that is, autumn‐early winter during the Delta wave and late winter‐early spring during Omicron wave 64,70 . Moreover, these analyzes were conducted separately for these waves, enabling an understanding of whether the association between air pollution and COVID‐19 is present under the dominance of clinically‐distinct viral variants.…”

Section: Discussionmentioning

confidence: 99%

Short‐term exposure to ambient air pollution and COVID‐19 severity during SARS‐CoV‐2 Delta and Omicron waves: A multicenter study

Poniedziałek

Rzymski

Zarębska-Michaluk

et al. 2023

Journal of Medical Virology

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Air pollution may affect the clinical course of respiratory diseases, including This study aimed to evaluate the relationship between exposure of adult patients to mean 24 h levels of particulate matter sized <10 μm (PM 10 ) and <2.5 μm (PM 2.5 ) and benzo(a)pyrene (B(a)P) during a week before their hospitalization due to SARS-CoV-2 infection and symptomatology, hyperinflammation, coagulopathy, the clinical course of disease, and outcome. The analyses were conducted during two pandemic waves: (i) dominated by highly pathogenic Delta variant (n = 1440) and (ii) clinically less-severe Omicron (n = 785), while the analyzed associations were adjusted for patient's age, BMI, gender, and comorbidities. The exposure to mean 24 h B(a)P exceeding the limits was associated with increased odds of fever and fatigue as early COVID-19 symptoms, hyperinflammation due to serum C-reactive protein >200 mg/L and interleukin-6 >100 pg/mL, coagulopathy due to D-dimer >2 mg/L and fatal outcome. Elevated PM 10 and PM 2.5 levels were associated with higher odds of respiratory symptoms, procalcitonin >0.25 ng/mL and interleukin >100 pg/mL, lower oxygen saturation, need for oxygen support, and death. The significant relationships between exposure to air pollutants and the course and outcomes of COVID-19 were observed during both

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"Environmental, health and economic benefits of emission reduction in residential sector – A case study for Poland"

Werner,

Porwisiak,

Kryza

et al. 2024

Atmospheric Pollution Research

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Modelling benzo(a)pyrene concentrations for different meteorological conditions – Analysis of lung cancer cases and associated economic costs

Cited by 8 publications

References 45 publications

Strategic Assessment of Boron-Enriched Carbon Dots/Naproxen: Diagnostic, Toxicity, and In Vivo Therapeutic Evaluation

Strategic Assessment of Boron-Enriched Carbon Dots/Naproxen: Diagnostic, Toxicity, and In Vivo Therapeutic Evaluation

Short‐term exposure to ambient air pollution and COVID‐19 severity during SARS‐CoV‐2 Delta and Omicron waves: A multicenter study

"Environmental, health and economic benefits of emission reduction in residential sector – A case study for Poland"

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